TGFB1I1

TGFB1I1
TGFB1I1
사용 가능한 구조
PDBOrtholog 검색: PDBe RCSB
식별자
에일리어스TGFB1I1, ARA55, HIC-5, HIC5, TSC-5 변환 성장인자 베타1 유도 전사체 1
외부 IDOMIM: 602353 MGI: 102784 HomoloGene: 7572 GenCard: TGFB1I1
맞춤법
종.인간마우스
엔트레즈
앙상블
유니프로트
RefSeq(mRNA)

NM_015927
NM_001042454
NM_001164719

NM_001289550
NM_001289551
NM_001289552
NM_001289553
NM_009365

RefSeq(단백질)

NP_001035919
NP_001158191
NP_057011
NP_001158191.1
NP_057011.2

NP_001276479
NP_001276480
NP_001276481
NP_001276482

장소(UCSC)Chr 16: 31.47 ~31.48 MbChr 7: 127.85 ~127.85 Mb
PubMed 검색[3][4]
위키데이터
인간 보기/편집마우스 표시/편집

TGFB1I1 [5][6]유전자에 의해 인체 내에서 코드되는 단백질성장인자 베타-1 유도 전사체 1 단백질.

상호 작용

TGFB1I1은 다음과 상호작용하는 으로 나타났습니다.

모델 유기체

모델 유기체는 TGFB1I1 기능의 연구에 사용되어 왔다.Wellcome Trust Sanger [14]Institute에서 조건부 녹아웃tm1b(KOMP)Wtsi 마우스 라인 Tgfb1i1이 생성되었습니다.수컷과 암컷은 표준화된 표현형[15] 검사를 통해 [16][17][18][19]결실의 효과를 확인했습니다.추가 화면 : - 심층면역학적 표현형[20]

Tgfb1i1 녹아웃 마우스 표현형

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레퍼런스

  1. ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000140682 - 앙상블, 2017년 5월
  2. ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000030782 - 앙상블, 2017년 5월
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Matsuya M, Sasaki H, Aoto H, Mitaka T, Nagura K, Ohba T, Ishino M, Takahashi S, Suzuki R, Sasaki T (Jan 1998). "Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions". The Journal of Biological Chemistry. 273 (2): 1003–14. doi:10.1074/jbc.273.2.1003. PMID 9422762.
  6. ^ Fujimoto N, Yeh S, Kang HY, Inui S, Chang HC, Mizokami A, Chang C (Mar 1999). "Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate". The Journal of Biological Chemistry. 274 (12): 8316–21. doi:10.1074/jbc.274.12.8316. PMID 10075738.
  7. ^ a b Wang X, Yang Y, Guo X, Sampson ER, Hsu CL, Tsai MY, Yeh S, Wu G, Guo Y, Chang C (May 2002). "Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator". The Journal of Biological Chemistry. 277 (18): 15426–31. doi:10.1074/jbc.M111218200. PMID 11856738.
  8. ^ He B, Minges JT, Lee LW, Wilson EM (Mar 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators". The Journal of Biological Chemistry. 277 (12): 10226–35. doi:10.1074/jbc.M111975200. PMID 11779876.
  9. ^ Carneiro AM, Ingram SL, Beaulieu JM, Sweeney A, Amara SG, Thomas SM, Caron MG, Torres GE (Aug 2002). "The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter". The Journal of Neuroscience. 22 (16): 7045–54. doi:10.1523/JNEUROSCI.22-16-07045.2002. PMC 6757888. PMID 12177201.
  10. ^ Jia Y, Ransom RF, Shibanuma M, Liu C, Welsh MJ, Smoyer WE (Oct 2001). "Identification and characterization of hic-5/ARA55 as an hsp27 binding protein". The Journal of Biological Chemistry. 276 (43): 39911–8. doi:10.1074/jbc.M103510200. PMID 11546764.
  11. ^ a b Thomas SM, Hagel M, Turner CE (Jan 1999). "Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin". Journal of Cell Science. 112 (2): 181–90. doi:10.1242/jcs.112.2.181. PMID 9858471.
  12. ^ Nishiya N, Tachibana K, Shibanuma M, Mashimo JI, Nose K (Aug 2001). "Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase". Molecular and Cellular Biology. 21 (16): 5332–45. doi:10.1128/MCB.21.16.5332-5345.2001. PMC 87257. PMID 11463817.
  13. ^ Nishiya N, Iwabuchi Y, Shibanuma M, Côté JF, Tremblay ML, Nose K (Apr 1999). "Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain". The Journal of Biological Chemistry. 274 (14): 9847–53. doi:10.1074/jbc.274.14.9847. PMID 10092676.
  14. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  15. ^ a b "International Mouse Phenotyping Consortium".
  16. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  17. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  18. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  19. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  20. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium".

추가 정보

외부 링크

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.