호모 사피엔스 종의 단백질 코드 유전자
이전 에는 TORC1(Transducer CREB activator CREB-Regulated Transcuer Of Regulated CREB activator 1 ([5] [6] [7] [8] CRTC1 유전자에 의해 인체에서 암호화되는 단백질 이다.태아의 뇌와 간, 성인의 심장, 골격근육, 간 및 침샘[9] [10]
임상적 의의 알츠하이머병 에서는 CRTC1의 생산이 차단된다.[11] TORC1은 NMDA 안티고네이션을 통한 케타민 유도 항우울 효과의 표적 단백질일 수 있다.
「 」를 참조해 주세요. 레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000105662 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000003575 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ (Feb 2003). "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway" . Nature Genetics . 33 (2): 208–13. doi :10.1038/ng1083 . PMID 12539049 . S2CID 23417795 . ^ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (Aug 2003). "TORCs: transducers of regulated CREB activity" . Molecular Cell . 12 (2): 413–23. doi :10.1016/j.molcel.2003.08.013 PMID 14536081 . ^ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (Oct 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells" . Proceedings of the National Academy of Sciences of the United States of America . 100 (21): 12147–52. doi :10.1073/pnas.1932773100 PMC 218727 PMID 14506290 . ^ "Entrez Gene: CRTC1 CREB regulated transcription coactivator 1" .^ Huret J-L. "CRTC1 (CREB regulated transcription coactivator 1)" . Atlas of Genetics and Cytogenetics in Oncology and Haematology . INSERM U 935, Genetics, Dept Medical Information, University Hospital of Poitiers. ^ Kovács KA, Steullet P, Steinmann M, Do KQ, Magistretti PJ, Halfon O, Cardinaux JR (Mar 2007). "TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity" . Proceedings of the National Academy of Sciences of the United States of America . 104 (11): 4700–5. Bibcode :2007PNAS..104.4700K . doi :10.1073/pnas.0607524104 PMC 1838663 PMID 17360587 . ^ Parra-Damas A, Valero J, Chen M, España J, Martín E, Ferrer I, Rodríguez-Alvarez J, Saura CA (Apr 2014). "Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages" . The Journal of Neuroscience . 34 (17): 5776–87. doi :10.1523/JNEUROSCI.5288-13.2014 PMC 6608295 PMID 24760838 .
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