핵수용체 공동활성화제 2

NCOA2
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1GWQ, 1GWR, 1M2Z, 1MV9, 1MVC, 1MZN, 1P93, 1T63, 1T65, 1UHL, 1YOK, 1ZDT, 1ZDU, 1ZKY, 2AO6, 2B1V1A2, 4IA3, 4IA7, 4IQR, 4IU7, 4IUI, 4IV2, 4IV4, 4IVW, 4IVY, 4IW6, 4IW8, 4IWC, 4IWF, 2LDC, 2YJDC, 3DC, 5DL4, 5E0W, 5E19, 4ZUC, 5DI7, 5I4V, 5E0X, 5E1C, 4ZWK, 5DYD, 5DIG, 5DKG, 5DTV, 5EC9, 5DX3, 5DRMDR5EGV, 5BNU, 5DI, 5DKE, 5DWG, 5DZH, 5DRJ, 5DWE
식별자
에일리어스	NCOA2, GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75, 핵수용체 공동활성화제 2
외부 ID	OMIM : 601993 MGI : 1276533 HomoloGene : 4768 GenCard : NCO2
유전자 위치(인간)
크르.	8번 염색체(인간)
끝.	70,403,808 bp
유전자 위치(마우스)
크르.	1번 염색체(마우스)
끝.	13,374,083 bp
RNA발현패턴
	상단 표시 위치:
	부고환 말뭉치; ; 내피 세포; ; 이차 난모세포; ; 정낭포; ; 제주날 점막; ; 양수; ; 경골; ; 구강; ; 결석골; ; 망막 색소 상피;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	단백질 이량화 활성; GO:0001105 트랜스크립션코액티베이터 액티비티; 전사 인자 결합; 크로마틴 결합; GO:0000980 RNA중합효소II 시스조절영역배열특이적 DNA결합; GO:0001948 단백질 결합; 핵수용체공활성화제활성; RNA중합효소II인트로닉전사조절영역배열특이적DNA결합; 신호수용체결합; 핵수용체결합; 아릴탄화수소수용체결합; 단백질 도메인 특이 결합; GO:0001200, GO:0001133, GO:0001201 DNA결합전사인자활성, RNA중합효소II 특이적;
셀룰러 컴포넌트	세포질; 핵소체; 핵; 핵체; 단백질 함유 복합체;
생물학적 과정	전사조절, DNA템플릿화; 티로글로불린트리요오드티로닌에 대한 세포반응; 율동 과정; RNA중합효소II에 의한 전사 음성 조절; 유전자발현주기조절; 전사, DNA 템플릿; 호르몬 자극에 대한 세포 반응; 포도당 대사 과정 조절; 일주 리듬; 담즙산 및 담즙염수송; 전사 음성 조절, DNA 템플릿; RNA중합효소II에 의한 전사의 양성 조절; 운동 리듬; 세포내수용체신호경로; 지질대사과정조절; 유전자 발현 조절; 프로게스테론에 대한 반응;
	출처:아미고 / QuickGO
맞춤법
	10499
	17978
	ENSG00000140396
	ENSMUSG0000000586
	문제 15596
	Q61026
NM_006540; NM_001321703; NM_001321707; NM_001321711; NM_001321712;
	NM_001321713
	NM_001077695; NM_008678; NM_001302702
NP_001308632; NP_001308636; NP_001308640; NP_001308641; NP_001308642;
	NP_006531
	NP_001289631; NP_032704
	위키데이터
인간 보기/편집	마우스 표시/편집

NCoA-2로도 알려진 핵수용체 공동활성화제 2는 인간에서 NCOA2 유전자에 의해 암호화되는 단백질이다.NCoA-2는 글루코콜티코이드 수용체 상호작용 단백질 1(GRIP1), 스테로이드 수용체 공동활성화제 2(SRC-2) 또는 전사 매개자/중간인자 2(TIF2)로도 자주 불린다.

기능.

NCoA-2는 여러 핵 수용체 상호작용 도메인과 내재 히스톤 아세틸전달효소 활성을 포함하는 전사핵조절단백질이다.NCOA2는 리간드 활성화 핵 수용체에 의해 DNA 촉진 부위로 모집된다.NCOA2는 차례로 히스톤을 아세틸화시켜 하류 DNA를 전사하기 쉽게 만든다.따라서 NCOA2는 DNA ^[5]^[6]발현을 상향 조절하는 핵수용체를 돕는다.

GREP1은 글루코콜티코이드 수용체와 간섭조절인자 1(IRF1)^[7]의 전사공활성제이다.

상호 작용

핵수용체 공동활성화제 2는 다음과 상호작용하는 것으로 나타났다.

AR,^[8]^[9]^[10]^[11]^[12]
ARNT,^[13]
BRCA1,^[14]^[15]
DDX17,^[16]
DDX5,^[16]
ESR1,^[11]^[16]^[17]^[18]^[19]
NR3C1,^[20]^[21]
PPFIA4,^[22]
PPARG,^[23]
RXRA,^[24]^[25]
SRA1 ^[16]및
VDR.^[11]^[17]^[24]^[26]

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000140396 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG0000000586 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Voegel JJ, Heine MJ, Zechel C, Chambon P, Gronemeyer H (1996). "TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors". EMBO J. 15 (14): 3667–75. doi:10.1002/j.1460-2075.1996.tb00736.x. PMC 452006. PMID 8670870.
^ Hong H, Kohli K, Garabedian MJ, Stallcup MR (1997). "GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors". Mol Cell Biol. 17 (5): 2735–44. doi:10.1128/MCB.17.5.2735. PMC 232124. PMID 9111344.
^ Bhandare R, Damera G, Banerjee A, Flammer JR, Keslacy S, Rogatsky I, Panettieri RA, Amrani Y, Tliba O (January 2010). "Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells". Am. J. Respir. Cell Mol. Biol. 42 (1): 9–15. doi:10.1165/rcmb.2009-0239RC. PMC 2809222. PMID 19805480.
^ Song LN, Coghlan M, Gelmann EP (2004). "Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor". Mol. Endocrinol. 18 (1): 70–85. doi:10.1210/me.2003-0189. PMID 14593076.
^ Ishitani K, Yoshida T, Kitagawa H, Ohta H, Nozawa S, Kato S (2003). "p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor". Biochem. Biophys. Res. Commun. 306 (3): 660–5. doi:10.1016/S0006-291X(03)01021-0. PMID 12810069.
^ Wang Q, Udayakumar TS, Vasaitis TS, Brodie AM, Fondell JD (2004). "Mechanistic relationship between androgen receptor polyglutamine tract truncation and androgen-dependent transcriptional hyperactivity in prostate cancer cells". J. Biol. Chem. 279 (17): 17319–28. doi:10.1074/jbc.M400970200. PMID 14966121.
^ ^a ^b ^c He B, Wilson EM (2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Mol. Cell. Biol. 23 (6): 2135–50. doi:10.1128/MCB.23.6.2135-2150.2003. PMC 149467. PMID 12612084.
^ Bai S, He B, Wilson EM (2005). "Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction". Mol. Cell. Biol. 25 (4): 1238–57. doi:10.1128/MCB.25.4.1238-1257.2005. PMC 548016. PMID 15684378.
^ Beischlag TV, Wang S, Rose DW, Torchia J, Reisz-Porszasz S, Muhammad K, Nelson WE, Probst MR, Rosenfeld MG, Hankinson O (2002). "Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex". Mol. Cell. Biol. 22 (12): 4319–33. doi:10.1128/MCB.22.12.4319-4333.2002. PMC 133867. PMID 12024042.
^ Rodriguez M, Yu X, Chen J, Songyang Z (2003). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10.1074/jbc.C300407200. PMID 14578343.
^ Park JJ, Irvine RA, Buchanan G, Koh SS, Park JM, Tilley WD, Stallcup MR, Press MF, Coetzee GA (2000). "Breast cancer susceptibility gene 1 (BRCAI) is a coactivator of the androgen receptor". Cancer Res. 60 (21): 5946–9. PMID 11085509.
^ ^a ^b ^c ^d Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S (2001). "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA". EMBO J. 20 (6): 1341–52. doi:10.1093/emboj/20.6.1341. PMC 145523. PMID 11250900.
^ ^a ^b Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–17. doi:10.1016/S0092-8674(03)00436-7. PMID 12837248.
^ Wärnmark A, Treuter E, Gustafsson JA, Hubbard RE, Brzozowski AM, Pike AC (2002). "Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha". J. Biol. Chem. 277 (24): 21862–8. doi:10.1074/jbc.M200764200. PMID 11937504.
^ Fenne IS, Hoang T, Hauglid M, Sagen JV, Lien EA, Mellgren G (2008). "Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase". Endocrinology. 149 (9): 4336–45. doi:10.1210/en.2008-0037. PMID 18499756.
^ Zilliacus J, Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson JA (2001). "Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140". Mol. Endocrinol. 15 (4): 501–11. doi:10.1210/mend.15.4.0624. PMID 11266503.
^ Bledsoe RK, Montana VG, Stanley TB, Delves CJ, Apolito CJ, McKee DD, Consler TG, Parks DJ, Stewart EL, Willson TM, Lambert MH, Moore JT, Pearce KH, Xu HE (2002). "Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition". Cell. 110 (1): 93–105. doi:10.1016/S0092-8674(02)00817-6. PMID 12151000.
^ Wyszynski M, Kim E, Dunah AW, Passafaro M, Valtschanoff JG, Serra-Pagès C, Streuli M, Weinberg RJ, Sheng M (2002). "Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting". Neuron. 34 (1): 39–52. doi:10.1016/S0896-6273(02)00640-2. PMID 11931740.
^ Kodera Y, Takeyama K, Murayama A, Suzawa M, Masuhiro Y, Kato S (2000). "Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators". J. Biol. Chem. 275 (43): 33201–4. doi:10.1074/jbc.C000517200. PMID 10944516.
^ ^a ^b Zhang C, Baudino TA, Dowd DR, Tokumaru H, Wang W, MacDonald PN (2001). "Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription". J. Biol. Chem. 276 (44): 40614–20. doi:10.1074/jbc.M106263200. PMID 11514567.
^ Lee WY, Noy N (2002). "Interactions of RXR with coactivators are differentially mediated by helix 11 of the receptor's ligand binding domain". Biochemistry. 41 (8): 2500–8. doi:10.1021/bi011764+. PMID 11851396.
^ Herdick M, Steinmeyer A, Carlberg C (2000). "Antagonistic action of a 25-carboxylic ester analogue of 1alpha, 25-dihydroxyvitamin D3 is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators". J. Biol. Chem. 275 (22): 16506–12. doi:10.1074/jbc.M910000199. PMID 10748178.

추가 정보

Voegel JJ, Heine MJ, Zechel C, Chambon P, Gronemeyer H (1996). "TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors". EMBO J. 15 (14): 3667–75. doi:10.1002/j.1460-2075.1996.tb00736.x. PMC 452006. PMID 8670870.
Hong H, Kohli K, Garabedian MJ, Stallcup MR (1997). "GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors". Mol. Cell. Biol. 17 (5): 2735–44. doi:10.1128/MCB.17.5.2735. PMC 232124. PMID 9111344.
Voegel JJ, Heine MJ, Tini M, Vivat V, Chambon P, Gronemeyer H (1998). "The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways". EMBO J. 17 (2): 507–19. doi:10.1093/emboj/17.2.507. PMC 1170401. PMID 9430642.
Carapeti M, Aguiar RC, Goldman JM, Cross NC (1998). "A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia". Blood. 91 (9): 3127–33. doi:10.1182/blood.V91.9.3127. PMID 9558366.
Fryer CJ, Archer TK (1998). "Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex". Nature. 393 (6680): 88–91. Bibcode:1998Natur.393...88F. doi:10.1038/30032. PMID 9590696. S2CID 2208522.
Berrevoets CA, Doesburg P, Steketee K, Trapman J, Brinkmann AO (1998). "Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary factor2)". Mol. Endocrinol. 12 (8): 1172–83. doi:10.1210/me.12.8.1172. PMID 9717843.
Wang JC, Stafford JM, Granner DK (1998). "SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4". J. Biol. Chem. 273 (47): 30847–50. doi:10.1074/jbc.273.47.30847. PMC 3968904. PMID 9812974.
Hong H, Darimont BD, Ma H, Yang L, Yamamoto KR, Stallcup MR (1999). "An additional region of coactivator GRIP1 required for interaction with the hormone-binding domains of a subset of nuclear receptors". J. Biol. Chem. 274 (6): 3496–502. doi:10.1074/jbc.274.6.3496. PMID 9920895.
Chen D, Ma H, Hong H, Koh SS, Huang SM, Schurter BT, Aswad DW, Stallcup MR (1999). "Regulation of transcription by a protein methyltransferase". Science. 284 (5423): 2174–7. doi:10.1126/science.284.5423.2174. PMID 10381882.
Ma H, Hong H, Huang SM, Irvine RA, Webb P, Kushner PJ, Coetzee GA, Stallcup MR (1999). "Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins". Mol. Cell. Biol. 19 (9): 6164–73. doi:10.1128/MCB.19.9.6164. PMC 84548. PMID 10454563.
Atkins GB, Hu X, Guenther MG, Rachez C, Freedman LP, Lazar MA (1999). "Coactivators for the orphan nuclear receptor RORalpha". Mol. Endocrinol. 13 (9): 1550–7. doi:10.1210/me.13.9.1550. PMID 10478845.
Carrero P, Okamoto K, Coumailleau P, O'Brien S, Tanaka H, Poellinger L (2000). "Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha". Mol. Cell. Biol. 20 (1): 402–15. doi:10.1128/MCB.20.1.402-415.2000. PMC 85095. PMID 10594042.
Xie W, Hong H, Yang NN, Lin RJ, Simon CM, Stallcup MR, Evans RM (2000). "Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2". Mol. Endocrinol. 13 (12): 2151–62. doi:10.1210/me.13.12.2151. PMID 10598588.
Naltner A, Ghaffari M, Whitsett JA, Yan C (2000). "Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent". J. Biol. Chem. 275 (1): 56–62. doi:10.1074/jbc.275.1.56. PMID 10617585.
Jimenez-Lara AM, Heine MJ, Gronemeyer H (2000). "Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family". FEBS Lett. 468 (2–3): 203–10. doi:10.1016/S0014-5793(00)01209-6. PMID 10692587. S2CID 8161180.
Poelzl G, Kasai Y, Mochizuki N, Shaul PW, Brown M, Mendelsohn ME (2000). "Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2836–9. Bibcode:2000PNAS...97.2836P. doi:10.1073/pnas.050580997. PMC 16016. PMID 10706629.
Herdick M, Steinmeyer A, Carlberg C (2000). "Antagonistic action of a 25-carboxylic ester analogue of 1alpha, 25-dihydroxyvitamin D3 is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators". J. Biol. Chem. 275 (22): 16506–12. doi:10.1074/jbc.M910000199. PMID 10748178.
Kodera Y, Takeyama K, Murayama A, Suzawa M, Masuhiro Y, Kato S (2000). "Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators". J. Biol. Chem. 275 (43): 33201–4. doi:10.1074/jbc.C000517200. PMID 10944516.
Koh SS, Chen D, Lee YH, Stallcup MR (2001). "Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities". J. Biol. Chem. 276 (2): 1089–98. doi:10.1074/jbc.M004228200. PMID 11050077.
Park JJ, Irvine RA, Buchanan G, Koh SS, Park JM, Tilley WD, Stallcup MR, Press MF, Coetzee GA (2000). "Breast cancer susceptibility gene 1 (BRCAI) is a coactivator of the androgen receptor". Cancer Res. 60 (21): 5946–9. PMID 11085509.

외부 링크

미국 국립의학도서관(MeSH)의 핵수용체 공동활성화제 2
누르사 C90
PDBe-KB의 UniProt: Q15596(Human Nuclear receptive coactivator 2)에 있는 PDB의 모든 구조 정보의 개요.
PDB의 UniProt: Q61026(Mouse Nuclear receptive coactivator 2)에서 PDBe-KB에 제공되는 모든 구조 정보의 개요.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000140396 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG0000000586 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Voegel_1996-5] Voegel JJ, Heine MJ, Zechel C, Chambon P, Gronemeyer H (1996). "TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors". EMBO J. 15 (14): 3667–75. doi:10.1002/j.1460-2075.1996.tb00736.x. PMC 452006. PMID 8670870.

[Hong_1997-6] Hong H, Kohli K, Garabedian MJ, Stallcup MR (1997). "GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors". Mol Cell Biol. 17 (5): 2735–44. doi:10.1128/MCB.17.5.2735. PMC 232124. PMID 9111344.

[pmid19805480-7] Bhandare R, Damera G, Banerjee A, Flammer JR, Keslacy S, Rogatsky I, Panettieri RA, Amrani Y, Tliba O (January 2010). "Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells". Am. J. Respir. Cell Mol. Biol. 42 (1): 9–15. doi:10.1165/rcmb.2009-0239RC. PMC 2809222. PMID 19805480.

[pmid14593076-8] Song LN, Coghlan M, Gelmann EP (2004). "Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor". Mol. Endocrinol. 18 (1): 70–85. doi:10.1210/me.2003-0189. PMID 14593076.

[pmid12810069-9] Ishitani K, Yoshida T, Kitagawa H, Ohta H, Nozawa S, Kato S (2003). "p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor". Biochem. Biophys. Res. Commun. 306 (3): 660–5. doi:10.1016/S0006-291X(03)01021-0. PMID 12810069.

[pmid14966121-10] Wang Q, Udayakumar TS, Vasaitis TS, Brodie AM, Fondell JD (2004). "Mechanistic relationship between androgen receptor polyglutamine tract truncation and androgen-dependent transcriptional hyperactivity in prostate cancer cells". J. Biol. Chem. 279 (17): 17319–28. doi:10.1074/jbc.M400970200. PMID 14966121.

[pmid12612084-11] He B, Wilson EM (2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Mol. Cell. Biol. 23 (6): 2135–50. doi:10.1128/MCB.23.6.2135-2150.2003. PMC 149467. PMID 12612084.

[pmid15684378-12] Bai S, He B, Wilson EM (2005). "Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction". Mol. Cell. Biol. 25 (4): 1238–57. doi:10.1128/MCB.25.4.1238-1257.2005. PMC 548016. PMID 15684378.

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v t 문자 변환 코아게이터
코액티베이터	ARA(54, 55, 70) BCAS3 CARM1 p300-CBP(EP300, CREBP) CRTC(1, 2, 3) 드립/트랩(MED1 드립205/트랩220) MN1 PCAF PNRC(1, 2) PPARGC(1A, 1B) TGFB1I1 NCOA1(SRC-1) NCOA2(GRIP1/SRC-2/TIF2) NCOA3(AIB/SRC-3/TRAM-1) NCOA4(ARA70) NCOA5(CIA) NCOA6(RAP250) NCOA7(ERAP140)
코어프레서	CTBP(1, 2) 털 없는 상동어 LCOR NRIP1(RIP140) PELP-1 RCOR1 Rb SIN3A SIN3B 삼분 모티브 패밀리트림(24, 28, 33) NCOR1 NCOR2(SMRT)
ATP의존성 리모델링인자	염색질구조리모델링(RSC)복합체 SWI/SNF

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