RCOR1 사용 가능한 구조 PDB Ortholog 검색: PDBe RCSB PDB ID 코드 목록 2IW5, 2UXN , 2UXX , 2V1D , 2X0L , 2XAF , 2XAG , 2XAH , 2XAJ , 2XAQ , 2XAS , 2Y48 , 3ZMS , 3ZMV , 3MUZ
식별자 에일리어스 RCOR1 외부 ID OMIM : 607675 MGI: 106340 HomoloGene : 32246 GenCard: RCOR1 맞춤법 종. 인간 마우스 엔트레즈 앙상블 유니프로트 RefSeq(mRNA) RefSeq(단백질) 장소(UCSC) Chr 14: 102.59 ~102.73 Mb Chr 12: 111.01 ~111.08 Mb PubMed 검색[3] [4] 위키데이터
REST 코어프레서 1은 CoREST라고도 알려져 있으며 RCOR1 [5] [6] 있는 단백질 이다.
기능. 이 유전자는 잘 보존되고, 태어날 때 조절이 잘 되고, 신경 세포 분화를 결정 하는 특정한 역할을 하는 단백질을 암호화합니다. 부호화된 단백질은 REST의 C 말단 도메인에 결합한다(억제소자-1 사일링 전사 인자).[6]
상호 작용 RCOR1은 다음과 상호작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000089902 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000037896 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Andrés ME, Burger C, Peral-Rubio MJ, Battaglioli E, Anderson ME, Grimes J, Dallman J, Ballas N, Mandel G (September 1999). "CoREST: a functional corepressor required for regulation of neural-specific gene expression" . Proc. Natl. Acad. Sci. U.S.A . 96 (17): 9873–8. Bibcode :1999PNAS...96.9873A . doi :10.1073/pnas.96.17.9873 PMC 22303 PMID 10449787 . ^ a b "Entrez Gene: RCOR1 REST corepressor 1" .^ a b c d Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes" . Proc. Natl. Acad. Sci. U.S.A . 99 (11): 7420–5. Bibcode :2002PNAS...99.7420H . doi :10.1073/pnas.112008599 PMC 124246 PMID 12032298 . ^ a b You A, Tong JK, Grozinger CM, Schreiber SL (February 2001). "CoREST is an integral component of the CoREST- human histone deacetylase complex" . Proc. Natl. Acad. Sci. U.S.A . 98 (4): 1454–8. Bibcode :2001PNAS...98.1454Y . doi :10.1073/pnas.98.4.1454 PMC 29278 PMID 11171972 . ^ Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (September 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun . 322 (2): 601–8. doi :10.1016/j.bbrc.2004.07.163 . PMID 15325272 .
추가 정보 Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1" . DNA Res . 1 (5): 223–9. doi :10.1093/dnares/1.5.223 PMID 7584044 . Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem . 236 (1): 107–13. doi :10.1006/abio.1996.0138 . PMID 8619474 . Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing" . Genome Res . 7 (4): 353–8. doi :10.1101/gr.7.4.353 . PMC 139146 PMID 9110174 . Grimes JA, Nielsen SJ, Battaglioli E, Miska EA, Speh JC, Berry DL, Atouf F, Holdener BC, Mandel G, Kouzarides T (2000). "The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex" . J. Biol. Chem . 275 (13): 9461–7. doi :10.1074/jbc.275.13.9461 PMID 10734093 . Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination" . Genome Res . 10 (11): 1788–95. doi :10.1101/gr.143000 . PMC 310948 PMID 11076863 . Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH (2001). "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1" . J. Biol. Chem . 276 (9): 6817–24. doi :10.1074/jbc.M007372200 PMID 11102443 . You A, Tong JK, Grozinger CM, Schreiber SL (2001). "CoREST is an integral component of the CoREST- human histone deacetylase complex" . Proc. Natl. Acad. Sci. U.S.A . 98 (4): 1454–8. Bibcode :2001PNAS...98.1454Y . doi :10.1073/pnas.98.4.1454 PMC 29278 PMID 11171972 . Ballas N, Battaglioli E, Atouf F, Andres ME, Chenoweth J, Anderson ME, Burger C, Moniwa M, Davie JR, Bowers WJ, Federoff HJ, Rose DW, Rosenfeld MG, Brehm P, Mandel G (2001). "Regulation of neuronal traits by a novel transcriptional complex" . Neuron . 31 (3): 353–65. doi :10.1016/S0896-6273(01)00371-3 PMID 11516394 . Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes" . Proc. Natl. Acad. Sci. U.S.A . 99 (11): 7420–5. Bibcode :2002PNAS...99.7420H . doi :10.1073/pnas.112008599 PMC 124246 PMID 12032298 . Battaglioli E, Andrés ME, Rose DW, Chenoweth JG, Rosenfeld MG, Anderson ME, Mandel G (2002). "REST repression of neuronal genes requires components of the hSWI.SNF complex" . J. Biol. Chem . 277 (43): 41038–45. doi :10.1074/jbc.M205691200 PMID 12192000 . Lunyak VV, Burgess R, Prefontaine GG, Nelson C, Sze SH, Chenoweth J, Schwartz P, Pevzner PA, Glass C, Mandel G, Rosenfeld MG (2002). "Corepressor-dependent silencing of chromosomal regions encoding neuronal genes". Science . 298 (5599): 1747–52. Bibcode :2002Sci...298.1747L . CiteSeerX 10.1.1.136.7131 doi :10.1126/science.1076469 . PMID 12399542 . S2CID 13507921 . Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes" . J. Biol. Chem . 278 (9): 7234–9. doi :10.1074/jbc.M208992200 PMID 12493763 . Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun . 322 (2): 601–8. doi :10.1016/j.bbrc.2004.07.163 . PMID 15325272 . Gu H, Liang Y, Mandel G, Roizman B (2005). "Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells" . Proc. Natl. Acad. Sci. U.S.A . 102 (21): 7571–6. Bibcode :2005PNAS..102.7571G . doi :10.1073/pnas.0502658102 PMC 1140450 PMID 15897453 . Lee MG, Wynder C, Cooch N, Shiekhattar R (2005). "An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation". Nature . 437 (7057): 432–5. Bibcode :2005Natur.437..432L . doi :10.1038/nature04021 . PMID 16079794 . S2CID 4396351 . Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y (2005). "Regulation of LSD1 histone demethylase activity by its associated factors" . Mol. Cell . 19 (6): 857–64. doi :10.1016/j.molcel.2005.08.027 PMID 16140033 . Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle" . Proc. Natl. Acad. Sci. U.S.A . 103 (14): 5391–6. Bibcode :2006PNAS..103.5391N . doi :10.1073/pnas.0507066103 PMC 1459365 PMID 16565220 .
PDB 갤러리
2iw5 : 인간 LSD1 히스톤 데메틸라아제에 의한 뉴클레오솜의 코어스트 의존성 탈메틸화를 위한 구조적 기초
2uxn : 자살 불활성화에 의해 밝혀진 LSD1에 의한 히스톤 탈메틸화의 구조적 기초
2v1d : 히스톤 H3 인식에서의 LSD1-Corest 선택성의 구조적 기반
이 기사에는 미국 국립 의학 도서관 (미국 국립 의학 도서관 )의 공공 도메인 텍스트가 포함되어 있습니다.
