BCAS3
BCAS3
BCAS3라고도 알려진 유방암 증폭 배열 3은 BCAS3 [5][6]유전자에 의해 인간에서 암호화되는 단백질이다.BCAS3는 유방암 [6]세포에서 증폭되고 과도하게 발현되는 유전자이다.
기능.
BCAS3 유전자는 에스트로겐 수용체 알파(ER-α)[7]에 의해 조절된다.PELP1 단백질은 에스트로겐 수용체 유도 BCAS3 유전자 발현의 전사적 공동활성화제 역할을 한다.BCAS3는 히스톤아세틸전달효소 활성을 가지며, 그 자체가 ER-α의 [8]공동활성제로서 작용하는 것으로 보인다.또한 BCAS3는 ER-α에서 PELP1이 공동활성제로서 기능하는 것을 요구한다.따라서 BCAS3는 ER-α 매개 신호 [8]증폭으로 이어지는 양의 피드백 루프에 관여하는 것으로 보인다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000141376 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000059439 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: BCAS3 breast carcinoma amplified sequence 3".
- ^ a b Bärlund M, Monni O, Weaver JD, Kauraniemi P, Sauter G, Heiskanen M, Kallioniemi OP, Kallioniemi A (December 2002). "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer". Genes Chromosomes Cancer. 35 (4): 311–7. doi:10.1002/gcc.10121. PMID 12378525. S2CID 9759638.
- ^ Gururaj AE, Singh RR, Rayala SK, Holm C, den Hollander P, Zhang H, Balasenthil S, Talukder AH, Landberg G, Kumar R (April 2006). "MTA1, a transcriptional activator of breast cancer amplified sequence 3". Proc. Natl. Acad. Sci. U.S.A. 103 (17): 6670–5. Bibcode:2006PNAS..103.6670G. doi:10.1073/pnas.0601989103. PMC 1458939. PMID 16617102.
- ^ a b Gururaj AE, Peng S, Vadlamudi RK, Kumar R (August 2007). "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)". Mol. Endocrinol. 21 (8): 1847–60. doi:10.1210/me.2006-0514. PMID 17505058.
외부 링크
- UCSC Genome Browser의 인간 BCAS3 게놈 위치 및 BCAS3 유전자 세부 정보 페이지.
추가 정보
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Bärlund M, Monni O, Weaver JD, et al. (2003). "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer". Genes Chromosomes Cancer. 35 (4): 311–7. doi:10.1002/gcc.10121. PMID 12378525. S2CID 9759638.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Gururaj AE, Singh RR, Rayala SK, et al. (2006). "MTA1, a transcriptional activator of breast cancer amplified sequence 3". Proc. Natl. Acad. Sci. U.S.A. 103 (17): 6670–5. Bibcode:2006PNAS..103.6670G. doi:10.1073/pnas.0601989103. PMC 1458939. PMID 16617102.
- Gururaj AE, Holm C, Landberg G, Kumar R (2006). "Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer". Cell Cycle. 5 (13): 1407–10. doi:10.4161/cc.5.13.2924. PMID 16855396.
- Gururaj AE, Peng S, Vadlamudi RK, Kumar R (2007). "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)". Mol. Endocrinol. 21 (8): 1847–60. doi:10.1210/me.2006-0514. PMID 17505058.
