호모 사피엔스 종의 단백질 코드 유전자
CRTC2 라고도 알려진 CREB 조절 전사 공활성제 2는 CRTC2 [5] [6] [7] 암호화 되는 단백질이다.
기능. 처음에 TORC2라고 불렸던 CRTC2는 전사 인자 CREB의 전사 공활성제 이며 [8] cAMP 에 반응 하는 글루코네제닉 유전자 발현의 중심 조절제이다. CRTC2는 LKB11/STK11-늘 비소세포 폐암(NSCLC) [9]
상호 작용 CRTC2는 SNF1LK2 [10] YWHAQ 와 [10] [11] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000160741 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000027936 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: CRTC2 CREB regulated transcription coactivator 2" .^ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, et al. (October 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells" . Proceedings of the National Academy of Sciences of the United States of America . 100 (21): 12147–52. doi :10.1073/pnas.1932773100 PMC 218727 PMID 14506290 . ^ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (August 2003). "TORCs: transducers of regulated CREB activity" . 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