JMJD6
JMJD6
비관능성 아르기닌 데메틸라아제 및 리실히드록실라아제 JMJD6는 JMJD6 [5][6]유전자에 의해 인체 내에서 코드되는 효소이다.
기능.
이 유전자는 핵단백질을 JmjC 도메인으로 암호화한다.JmjC 도메인 함유 단백질은 α-케토글루타르산 의존성 히드록실화효소 슈퍼패밀리에 속한다.그것들은 단백질 히드록실화효소 또는 히스톤 데메틸라아제 역할을 할 것으로 예측된다.이 단백질은 아포토시스 세포의 식세포증에 관여하는 추정 포스파티딜세린 수용체로 처음 확인되었다.후속 연구는 단백질이 포스파티딜세린 수용체를 인식하고 아포토시스 세포의 클리어런스에서 직접적으로 기능하지 않는 모노클로널 항체와 교차 반응할 수 있음을 시사한다.이 [6]유전자에 대해 서로 다른 아이소폼을 코드하는 여러 개의 전사 변형이 발견되었다.생리학적 차원에서 JMJD6는 혈관형성 과정인 혈관신생에서 역할을 하는 반면, 병태생리학적 과정에서의 JMJD6의 추가적인 역할(유방종양유전 등)[7]이 관련되었다.여기에서 [8]JMJD6 수치가 높아진 것은 생쥐의 공격성 및 전이와 관련된 유방암에서 발견되었다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000070495 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000056962 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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- ^ a b "Entrez Gene: JMJD6 jumonji domain containing 6".
- ^ Boeckel JN, Guarani V, Koyanagi M, Roexe T, Lengeling A, Schermuly RT, Gellert P, Braun T, Zeiher A, Dimmeler S (February 2011). "Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1". Proceedings of the National Academy of Sciences of the United States of America. 108 (8): 3276–81. Bibcode:2011PNAS..108.3276B. doi:10.1073/pnas.1008098108. PMC 3044381. PMID 21300889.
- ^ Aprelikova O, Chen K, El Touny LH, Brignatz-Guittard C, Han J, Qiu T, Yang HH, Lee MP, Zhu M, Green JE (14 Apr 2016). "The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis". Clin Epigenetics. 8 (38): 38. doi:10.1186/s13148-016-0205-6. PMC 4831179. PMID 27081402.
추가 정보
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