호모 사피엔스 종의 단백질 코드 유전자
분해효소 및 메탈로프로테이나아제 도메인 함유 단백질 28은 ADAM28 [5] 효소 이다.
이 유전자는 ADAM(분해 및 금속단백질가수분해효소 도메인) 패밀리의 일원을 암호화합니다. 이 과의 구성원은 뱀 독 분해물과 구조적으로 관련된 막 고정 단백질이며 수정, 근육 발달 및 신경 발생을 포함한 세포-세포 및 세포-매트릭스 상호작용과 관련된 다양한 생물학적 과정에 관여해왔다. 이 유전자에 의해 코드된 단백질은 림프구 발현 ADAM 단백질이다. 대체 스플라이싱은 두 가지 트랜스크립트 변형을 낳습니다. 짧은 버전은 분비된 isoform을 인코딩하고 긴 버전은 transmembrane isoform을 [5]
레퍼런스 추가 정보 Roberts CM, Tani PH, Bridges LC, et al. (1999). "MDC-L, a novel metalloprotease disintegrin cysteine-rich protein family member expressed by human lymphocytes" . J. Biol. Chem . 274 (41): 29251–29259. doi :10.1074/jbc.274.41.29251 PMID 10506182 . Jury JA, Perry AC, Hall L (2000). "Identification, sequence analysis and expression of transcripts encoding a putative metalloproteinase, eMDC II, in human and macaque epididymis" . Mol. Hum. Reprod . 5 (12): 1127–1134. doi :10.1093/molehr/5.12.1127 PMID 10587367 . Howard L, Maciewicz RA, Blobel CP (2000). "Cloning and characterization of ADAM28: evidence for autocatalytic pro-domain removal and for cell surface localization of mature ADAM28" . Biochem. J . 348 Pt 1 (Pt 1): 21–27. doi :10.1042/0264-6021:3480021 . PMC 1221031 PMID 10794709 . Bridges LC, Tani PH, Hanson KR, et al. (2002). "The lymphocyte metalloprotease MDC-L (ADAM 28) is a ligand for the integrin alpha4beta1" . J. Biol. Chem . 277 (5): 3784–3792. doi :10.1074/jbc.M109538200 PMID 11724793 . Bridges LC, Hanson KR, Tani PH, et al. (2003). "Integrin alpha4beta1-dependent adhesion to ADAM 28 (MDC-L) requires an extended surface of the disintegrin domain". Biochemistry . 42 (13): 3734–3741. doi :10.1021/bi026871y . PMID 12667064 . Fourie AM, Coles F, Moreno V, Karlsson L (2003). "Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23" . J. Biol. Chem . 278 (33): 30469–30477. doi :10.1074/jbc.M213157200 PMID 12777399 . Mochizuki S, Shimoda M, Shiomi T, et al. (2004). "ADAM28 is activated by MMP-7 (matrilysin-1) and cleaves insulin-like growth factor binding protein-3". Biochem. Biophys. Res. Commun . 315 (1): 79–84. doi :10.1016/j.bbrc.2004.01.022 . PMID 15013428 . Ohtsuka T, Shiomi T, Shimoda M, et al. (2006). "ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis" . Int. J. Cancer . 118 (2): 263–273. doi :10.1002/ijc.21324 PMID 16052521 . S2CID 19344958 . Mitsui Y, Mochizuki S, Kodama T, et al. (2006). "ADAM28 is overexpressed in human breast carcinomas: implications for carcinoma cell proliferation through cleavage of insulin-like growth factor binding protein-3" . Cancer Res . 66 (20): 9913–9920. doi :10.1158/0008-5472.CAN-06-0377 PMID 17047053 . Shimoda M, Hashimoto G, Mochizuki S, et al. (2007). "Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells" . J. Biol. Chem . 282 (35): 25864–25874. doi :10.1074/jbc.M702414200 PMID 17597069 .
외부 링크
