ADAM33

ADAM33
ADAM33
Protein ADAM33 PDB 1r54.png
사용 가능한 구조물
PDB직교 검색: PDBe RCSB
식별자
별칭ADAM33, C20orf153, DJ964F7.1, ADAM metaloptidase 도메인 33
외부 IDOMIM: 607114 MGI: 1341813 호몰로진: 11881 GeneCard: ADAM33
직교체
종인간마우스
엔트레스

80332

110751

앙상블

ENSG00000149451

ENSMUSG00000027318

유니프로트

Q9BZ11
Q08AM2

Q923W9

RefSeq(mRNA)

NM_00128247
NM_025220
NM_153202

NM_001163529
NM_033615

RefSeq(단백질)

NP_001269376
NP_079496
NP_694882

NP_001157001
NP_291093

위치(UCSC)Chr 20: 3.67 – 3.68MbChr 2: 131.05 – 131.06Mb
PubMed 검색[3][4]
위키다타
인간 보기/편집마우스 보기/편집

디제인 및 메탈로프로테이트나아제 도메인 함유 단백질 33은 인간에서 ADAM33 유전자에 의해 암호화된 효소다.[5][6]

함수

이 유전자는 ADAM 계열의 구성원을 암호로 한다. 이 과의 구성원들은 구조적으로 뱀독 분해와 관련된 막 부착 단백질이며 수정, 근육 발달, 신경 유전자를 포함한 세포와 세포 매트릭스 상호작용을 포함하는 다양한 생물학적 과정에 관여해왔다. 이 단백질은 천식과 기관지 과민반응에 관여하는 1종 투과단백질이다.[7] 이 유전자의 대체적인 스플라이싱은 서로 다른 이소 형태를 인코딩하는 두 가지 대본 변형을 초래한다.[6]

참조

  1. ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000149451 - 앙상블, 2017년 5월
  2. ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000027318 - 앙상블, 2017년 5월
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yoshinaka T, Nishii K, Yamada K, Sawada H, Nishiwaki E, Smith K, Yoshino K, Ishiguro H, Higashiyama S (January 2002). "Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity". Gene. 282 (1–2): 227–36. doi:10.1016/S0378-1119(01)00818-6. PMID 11814695.
  6. ^ a b "Entrez Gene: ADAM33 ADAM metallopeptidase domain 33".
  7. ^ Davies ER, Kelly JF, Howarth PH, Wilson DI, Holgate ST, Davies DE, Whitsett JA, Haitchi HM (2016-07-21). "Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life". JCI Insight. 1 (11). doi:10.1172/jci.insight.87632. ISSN 0021-9738. PMC 4968941. PMID 27489884.

추가 읽기

  • Holgate ST, Davies DE, Rorke S, Cakebread J, Murphy G, Powell RM, Holloway JW (August 2004). "ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma". Clinical Reviews in Allergy & Immunology. 27 (1): 23–34. doi:10.1385/CRIAI:27:1:023. PMID 15347848. S2CID 23971367.
  • Holloway JW, Davies DE, Powell R, Haitchi HM, Keith TP, Holgate ST (August 2004). "The discovery and role of ADAM33, a new candidate gene for asthma". Expert Reviews in Molecular Medicine. 6 (17): 1–12. doi:10.1017/S1462399404007963. PMID 15387895.
  • Holgate ST, Yang Y, Haitchi HM, Powell RM, Holloway JW, Yoshisue H, Pang YY, Cakebread J, Davies DE (July 2006). "The genetics of asthma: ADAM33 as an example of a susceptibility gene". Proceedings of the American Thoracic Society. 3 (5): 440–3. doi:10.1513/pats.200603-026AW. PMID 16799089.
  • Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, Torrey D, Pandit S, McKenny J, Braunschweiger K, Walsh A, Liu Z, Hayward B, Folz C, Manning SP, Bawa A, Saracino L, Thackston M, Benchekroun Y, Capparell N, Wang M, Adair R, Feng Y, Dubois J, FitzGerald MG, Huang H, Gibson R, Allen KM, Pedan A, Danzig MR, Umland SP, Egan RW, Cuss FM, Rorke S, Clough JB, Holloway JW, Holgate ST, Keith TP (July 2002). "Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness". Nature. 418 (6896): 426–30. doi:10.1038/nature00878. PMID 12110844. S2CID 4424215.
  • Garlisi CG, Zou J, Devito KE, Tian F, Zhu FX, Liu J, Shah H, Wan Y, Motasim Billah M, Egan RW, Umland SP (January 2003). "Human ADAM33: protein maturation and localization". Biochemical and Biophysical Research Communications. 301 (1): 35–43. doi:10.1016/S0006-291X(02)02976-5. PMID 12535637.
  • Chae SC, Yoon KH, Chung HT (2003). "Identification of novel polymorphisms in the Adam33 gene". Journal of Human Genetics. 48 (5): 278–81. doi:10.1007/s10038-003-0019-1. PMID 12768445.
  • Howard TD, Postma DS, Jongepier H, Moore WC, Koppelman GH, Zheng SL, Xu J, Bleecker ER, Meyers DA (October 2003). "Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations". The Journal of Allergy and Clinical Immunology. 112 (4): 717–22. doi:10.1016/s0091-6749(03)01939-0. PMID 14564349.
  • Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, Ingram RN, Xiao L, Mirza UA, Zou J, Strickland C, Taremi SS, Le HV, Madison V (January 2004). "Crystal structure of the catalytic domain of human ADAM33". Journal of Molecular Biology. 335 (1): 129–37. doi:10.1016/j.jmb.2003.10.037. PMID 14659745.
  • Zou J, Zhu F, Liu J, Wang W, Zhang R, Garlisi CG, Liu YH, Wang S, Shah H, Wan Y, Umland SP (March 2004). "Catalytic activity of human ADAM33". The Journal of Biological Chemistry. 279 (11): 9818–30. doi:10.1074/jbc.M309696200. PMID 14676211.
  • Powell RM, Wicks J, Holloway JW, Holgate ST, Davies DE (July 2004). "The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts". American Journal of Respiratory Cell and Molecular Biology. 31 (1): 13–21. doi:10.1165/rcmb.2003-0330OC. PMID 14742294.
  • Haitchi HM, Powell RM, Shaw TJ, Howarth PH, Wilson SJ, Wilson DI, Holgate ST, Davies DE (May 2005). "ADAM33 expression in asthmatic airways and human embryonic lungs". American Journal of Respiratory and Critical Care Medicine. 171 (9): 958–65. doi:10.1164/rccm.200409-1251OC. PMID 15709049.
  • Zou J, Zhang R, Zhu F, Liu J, Madison V, Umland SP (March 2005). "ADAM33 enzyme properties and substrate specificity". Biochemistry. 44 (11): 4247–56. doi:10.1021/bi0476230. PMID 15766253.
  • Simpson A, Maniatis N, Jury F, Cakebread JA, Lowe LA, Holgate ST, Woodcock A, Ollier WE, Collins A, Custovic A, Holloway JW, John SL (July 2005). "Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function". American Journal of Respiratory and Critical Care Medicine. 172 (1): 55–60. doi:10.1164/rccm.200412-1708OC. PMID 15805180.

외부 링크


Stub icon

인간 20번 염색체의 유전자에 관한 이 기사는 단조롭다. 위키피디아를 확장하여 도울 수 있다.