이 유전자는 ADAM 계열의 구성원을 암호로 한다. 이 과의 구성원들은 구조적으로 뱀독 분해와 관련된 막 부착 단백질이며 수정, 근육 발달, 신경 유전자를 포함한 세포와 세포 매트릭스 상호작용을 포함하는 다양한 생물학적 과정에 관여해왔다. 이 단백질은 천식과 기관지 과민반응에 관여하는 1종 투과단백질이다.[7] 이 유전자의 대체적인 스플라이싱은 서로 다른 이소 형태를 인코딩하는 두 가지 대본 변형을 초래한다.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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Garlisi CG, Zou J, Devito KE, Tian F, Zhu FX, Liu J, Shah H, Wan Y, Motasim Billah M, Egan RW, Umland SP (January 2003). "Human ADAM33: protein maturation and localization". Biochemical and Biophysical Research Communications. 301 (1): 35–43. doi:10.1016/S0006-291X(02)02976-5. PMID12535637.
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Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, Ingram RN, Xiao L, Mirza UA, Zou J, Strickland C, Taremi SS, Le HV, Madison V (January 2004). "Crystal structure of the catalytic domain of human ADAM33". Journal of Molecular Biology. 335 (1): 129–37. doi:10.1016/j.jmb.2003.10.037. PMID14659745.
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