트립토판 N-모노옥시제네아제
Tryptophan N-monooxygenase| 트립토판 N-모노옥시제네아제 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 식별자 | |||||||||
| EC 번호 | 1.14.13.125 | ||||||||
| 데이터베이스 | |||||||||
| 인텐츠 | IntEnz 뷰 | ||||||||
| 브렌다 | 브렌다 입력 | ||||||||
| 엑스퍼시 | 나이스자이메 뷰 | ||||||||
| 케그 | KEG 입력 | ||||||||
| 메타사이크 | 대사통로 | ||||||||
| 프리암 | 프로필 | ||||||||
| PDB 구조 | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Tryptophan N-monooxygenase (EC 1.14.13.125, tryptophan N-hydroxylase, CYP79B1, CYP79B2, CYP79B3) is an enzyme with systematic name L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating).[1][2][3][4]이 효소는 다음과 같은 화학 반응을 촉진한다.
- L-트립토판 + 2 O2 + 2 NADPH + 2+ H E)-indol-3-ylacetaldoime + 2 NADP+ + CO2 + 3 HO2(전반작용)
- (1)L-트립토판 + O2 + NADPH + H++ {\}N-hydroxy-L-tryptophan + NADP+ + HO2
- (1b) N-hydroxy-L-triptophan + O2 + NADPH + H+ N, N-dihydroxy-L-triptophan + NADP+ + HO2
- (1) N, N, N-dihydroxy-L-tryptophan hanE)-indol-3-ylacetaldoxime + CO2 + HO2
트립토판 N-monooxygenase는 헤메-thiolate 단백질(P-450)이다.
참조
- ^ Mikkelsen MD, Hansen CH, Wittstock U, Halkier BA (October 2000). "Cytochrome P450 CYP79B2 from Arabidopsis catalyzes the conversion of tryptophan to indole-3-acetaldoxime, a precursor of indole glucosinolates and indole-3-acetic acid". The Journal of Biological Chemistry. 275 (43): 33712–7. doi:10.1074/jbc.M001667200. PMID 10922360.
- ^ Hull AK, Vij R, Celenza JL (February 2000). "Arabidopsis cytochrome P450s that catalyze the first step of tryptophan-dependent indole-3-acetic acid biosynthesis". Proceedings of the National Academy of Sciences of the United States of America. 97 (5): 2379–84. doi:10.1073/pnas.040569997. PMC 15809. PMID 10681464.
- ^ Zhao Y, Hull AK, Gupta NR, Goss KA, Alonso J, Ecker JR, Normanly J, Chory J, Celenza JL (December 2002). "Trp-dependent auxin biosynthesis in Arabidopsis: involvement of cytochrome P450s CYP79B2 and CYP79B3". Genes & Development. 16 (23): 3100–12. doi:10.1101/gad.1035402. PMC 187496. PMID 12464638.
- ^ Naur P, Hansen CH, Bak S, Hansen BG, Jensen NB, Nielsen HL, Halkier BA (January 2003). "CYP79B1 from Sinapis alba converts tryptophan to indole-3-acetaldoxime". Archives of Biochemistry and Biophysics. 409 (1): 235–41. doi:10.1016/s0003-9861(02)00567-2. PMID 12464264.
외부 링크
- 미국 국립 의학 도서관의 Tryptophan+N-monoxygenase(Tryptophan+N-monooxygenase)
