TNP2

TNP2
식별자
별칭	TNP2, TP2, 전환 단백질 2(히스톤에서 프로타민으로 교체하는 동안), 전환 단백질 2
외부 ID	OMIM: 190232 호몰로진: 3958 GeneCard: TNP2
유전자 위치(인간)
쳇.	16번 염색체(인간)
끝	11,269,533 bp
RNA 표현 패턴
	표현된 상단
	고환; ; 갑상선; ; 머리를 쓰다; ; 중추신경계; ; 대뇌피질; ; 하트; ; 췌장;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	DNA 결합; 금속 이온 결합; 아연 이온 결합;
셀룰러 컴포넌트	남성 생식 세포핵; 뉴클레오솜의; 핵의; 염색체;
생물학적 과정	다세포 유기체 개발; 세포 분화; 정자생식; 신랄한 반응; 조나 펠루치다의 침투; 단백질 처리의 양성 규제; 정조세포, 염색체 단백질의 교환;
	출처:아미고 / 퀵고
직교체
	7142
	n/a
	ENSG00000178279
	n/a
	Q05952
	n/a
	NM_005425
	n/a
	NP_005416
	n/a
	위키다타
인간 보기/편집

핵 전이 단백질 2는 인간에게 TNP2 유전자에 의해 암호화된 단백질이다.^[3]^[4]^[5]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000178279 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Engel W, Keime S, Kremling H, Hameister H, Schluter G (Nov 1992). "The genes for protamine 1 and 2 (PRM1 and PRM2) and transition protein 2 (TNP2) are closely linked in the mammalian genome". Cytogenet Cell Genet. 61 (2): 158–9. doi:10.1159/000133397. PMID 1395729.
^ Baskaran R, Rao MR (Jan 1991). "Interaction of spermatid-specific protein TP2 with nucleic acids, in vitro. A comparative study with TP1". J Biol Chem. 265 (34): 21039–47. doi:10.1016/S0021-9258(17)45324-5. PMID 2250010.
^ "Entrez Gene: TNP2 transition protein 2 (during histone to protamine replacement)".

추가 읽기

Schlüter G, Kremling H, Engel W (1992). "The gene for human transition protein 2: nucleotide sequence, assignment to the protamine gene cluster, and evidence for its low expression". Genomics. 14 (2): 377–83. doi:10.1016/S0888-7543(05)80229-0. PMID 1385303.
Kundu TK, Rao MR (1995). "DNA condensation by the rat spermatidal protein TP2 shows GC-rich sequence preference and is zinc dependent". Biochemistry. 34 (15): 5143–50. doi:10.1021/bi00015a027. PMID 7711033.
Nelson JE, Krawetz SA (1995). "Characterization of a human locus in transition". J. Biol. Chem. 269 (49): 31067–73. doi:10.1016/S0021-9258(18)47391-7. PMID 7983046.
Nelson JE, Krawetz SA (1993). "Linkage of human spermatid-specific basic nuclear protein genes. Definition and evolution of the P1-->P2-->TP2 locus". J. Biol. Chem. 268 (4): 2932–6. doi:10.1016/S0021-9258(18)53863-1. PMID 8428967.
Kundu TK, Rao MR (1997). "Zinc dependent recognition of a human CpG island sequence by the mammalian spermatidal protein TP2". Biochemistry. 35 (49): 15626–32. doi:10.1021/bi961271i. PMID 8961924.
Steger K, Klonisch T, Gavenis K, et al. (1999). "Expression of mRNA and protein of nucleoproteins during human spermiogenesis". Mol. Hum. Reprod. 4 (10): 939–45. doi:10.1093/molehr/4.10.939. PMID 9809674.
Wyckoff GJ, Wang W, Wu CI (2000). "Rapid evolution of male reproductive genes in the descent of man". Nature. 403 (6767): 304–9. doi:10.1038/35002070. PMID 10659848. S2CID 3136139.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wykes SM, Krawetz SA (2003). "The structural organization of sperm chromatin". J. Biol. Chem. 278 (32): 29471–7. doi:10.1074/jbc.M304545200. PMID 12775710.
Miyagawa Y, Nishimura H, Tsujimura A, et al. (2006). "Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations". J. Androl. 26 (6): 779–86. doi:10.2164/jandrol.05069. PMID 16291974.
Jedrzejczak P, Kempisty B, Bryja A, et al. (2007). "Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men". Arch. Androl. 53 (4): 199–205. doi:10.1080/01485010701426430. PMID 17852044. S2CID 21999596.

16번 염색체의 유전자에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000178279 - 앙상블, 2017년 5월

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1395729-3] Engel W, Keime S, Kremling H, Hameister H, Schluter G (Nov 1992). "The genes for protamine 1 and 2 (PRM1 and PRM2) and transition protein 2 (TNP2) are closely linked in the mammalian genome". Cytogenet Cell Genet. 61 (2): 158–9. doi:10.1159/000133397. PMID 1395729.

[pmid2250010-4] Baskaran R, Rao MR (Jan 1991). "Interaction of spermatid-specific protein TP2 with nucleic acids, in vitro. A comparative study with TP1". J Biol Chem. 265 (34): 21039–47. doi:10.1016/S0021-9258(17)45324-5. PMID 2250010.

[entrez-5] "Entrez Gene: TNP2 transition protein 2 (during histone to protamine replacement)".

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