뉴클레오폴린50 (Nup50 )은 NUP50 [5] [6] 단백질 이다.
핵공 복합체는 핵과 세포질 사이의 고분자의 흐름을 조절하는 관문을 형성하는 핵 외피를 가로질러 뻗어 있는 거대한 구조이다. 뉴클레오폴린은 진핵세포에서 핵공 복합체의 주요 구성요소이다. 이 유전자에 의해 코드된 단백질은 importin-alpha:beta 매개 핵단백질 수입의 가용성 보조인자로 기능하는 뉴클레오포린을 포함하는 FG-반복의 구성원이다. 이 유전자의 유사 유전자는 5, 6, 14번 염색체에서 발견됩니다. 이 [6]
상호 작용 NUP50은 KPNB1 [7] CDKN1B 와 [8] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000093000 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000016619 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Trichet V, Shkolny D, Dunham I, Beare D, McDermid HE (October 1999). "Mapping and complex expression pattern of the human NPAP60L nucleoporin gene". Cytogenet Cell Genet . 85 (3–4): 221–6. doi :10.1159/000015297 . PMID 10449902 . S2CID 38773521 . ^ a b "Entrez Gene: NUP50 nucleoporin 50kDa" .^ Lindsay, Mark E; Plafker Kendra; Smith Alicia E; Clurman Bruce E; Macara Ian G (August 2002). "Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import" . Cell . 110 (3): 349–60. doi :10.1016/S0092-8674(02)00836-X ISSN 0092-8674 . PMID 12176322 . ^ Smitherman, M; Lee K; Swanger J; Kapur R; Clurman B E (August 2000). "Characterization and Targeted Disruption of Murine Nup50, a p27Kip1-Interacting Component of the Nuclear Pore Complex" . Mol. Cell. Biol . 20 (15): 5631–42. doi :10.1128/MCB.20.15.5631-5642.2000 . ISSN 0270-7306 . PMC 86029 PMID 10891500 .
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