NUP98
NUP98| NUP98 | |||||||||||||||||||||||||
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| 식별자 | |||||||||||||||||||||||||
| 별칭 | NUP98, ADIR2, NUP196, NUP96, 핵포폴린 98kDa, 핵포폴린 98 | ||||||||||||||||||||||||
| 외부 ID | OMIM: 601021 MGI: 109404 HomoloGene: 35472 GeneCard: NUP98 | ||||||||||||||||||||||||
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| 직교체 | |||||||||||||||||||||||||
| 종 | 인간 | 마우스 | |||||||||||||||||||||||
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| 앙상블 | |||||||||||||||||||||||||
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| RefSeq(단백질) |
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| 위치(UCSC) | Chr 11: 3.67 – 3.8Mb | Chr 7: 101.77 – 101.86Mb | |||||||||||||||||||||||
| PubMed 검색 | [3] | [4] | |||||||||||||||||||||||
| 위키다타 | |||||||||||||||||||||||||
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핵공기 복합단백질 누프98-누프96은 인간에서 NUP98 유전자에 의해 암호화된 단백질이다.[5]
함수
신호 매개 핵 수출입은 핵포폴린으로 알려진 약 30개의 고유 단백질로 구성된 핵공기 복합체(NPC)를 통해 진행된다.98 kD 뉴클레오폴린은 186 kD 전구단백질의 합성과 단백질 분해능을 수반하는 바이오제너시스 경로를 통해 생성된다.이 갈라짐으로 인해 98 kD 뉴클레오폴린과 96 kD 뉴클레오폴린이 발생하며, 이 두 가지 모두 NPC의 핵소형 쪽에 국부화되어 있다.래트 연구는 98 kD 뉴클레오폴린이 운송 기판의 여러 도킹 부위 뉴클레오폴린 중 하나로 기능한다는 것을 보여준다.인간 유전자는 급성 골수성 백혈병(AML)과 T세포 급성 림프구 백혈병(T-ALL)에서 염색체 번식에 이어 여러 유전자에 융합되는 것으로 나타났다.이 유전자는 중요한 종양 억제 유전자 영역인 11p15.5의 각인된 유전자 영역에 위치한 여러 유전자 중 하나이다.이 지역의 변화는 벡위드-위데만 증후군, 윌름스 종양, 횡문근육종, 부항암, 폐, 난소, 유방암과 연관되어 있다.이 유전자의 대체적 결합은 몇 가지 대본 변형을 낳지만, 모든 변형이 완전히 설명되지는 않았다.[6]
상호작용
NUP98은 다음과 상호 작용하는 것으로 나타났다.
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000110713 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000063550 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Arai Y, Hosoda F, Kobayashi H, Arai K, Hayashi Y, Kamada N, Kaneko Y, Ohki M (June 1997). "The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10". Blood. 89 (11): 3936–44. doi:10.1182/blood.V89.11.3936. PMID 9166830.
- ^ "Entrez Gene: NUP98 nucleoporin 98kDa".
- ^ Kasper LH, Brindle PK, Schnabel CA, Pritchard CE, Cleary ML, van Deursen JM (January 1999). "CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity". Mol. Cell. Biol. 19 (1): 764–76. doi:10.1128/mcb.19.1.764. PMC 83933. PMID 9858599.
- ^ Moroianu J, Blobel G, Radu A (September 1997). "RanGTP-mediated nuclear export of karyopherin alpha involves its interaction with the nucleoporin Nup153". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9699–704. Bibcode:1997PNAS...94.9699M. doi:10.1073/pnas.94.18.9699. PMC 23253. PMID 9275187.
- ^ Bonifaci N, Moroianu J, Radu A, Blobel G (May 1997). "Karyopherin beta2 mediates nuclear import of a mRNA binding protein". Proc. Natl. Acad. Sci. U.S.A. 94 (10): 5055–60. Bibcode:1997PNAS...94.5055B. doi:10.1073/pnas.94.10.5055. PMC 24630. PMID 9144189.
- ^ Griffis ER, Xu S, Powers MA (February 2003). "Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes". Mol. Biol. Cell. 14 (2): 600–10. doi:10.1091/mbc.E02-09-0582. PMC 149995. PMID 12589057.
- ^ Pritchard CE, Fornerod M, Kasper LH, van Deursen JM (April 1999). "RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains". J. Cell Biol. 145 (2): 237–54. doi:10.1083/jcb.145.2.237. PMC 2133102. PMID 10209021.
- ^ Fontoura BM, Blobel G, Yaseen NR (October 2000). "The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import". J. Biol. Chem. 275 (40): 31289–96. doi:10.1074/jbc.M004651200. PMID 10875935.
추가 읽기
- Slape C, Aplan PD (2004). "The role of NUP98 gene fusions in hematologic malignancy". Leuk. Lymphoma. 45 (7): 1341–50. doi:10.1080/10428190310001659325. PMID 15359631. S2CID 20926084.
- Moore MA, Chung KY, Plasilova M, Schuringa JJ, Shieh JH, Zhou P, Morrone G (2007). "NUP98 dysregulation in myeloid leukemogenesis". Ann. N. Y. Acad. Sci. 1106 (1): 114–42. Bibcode:2007NYASA1106..114M. doi:10.1196/annals.1392.019. PMID 17442773. S2CID 25039911.
- Radu A, Moore MS, Blobel G (1995). "The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex". Cell. 81 (2): 215–22. doi:10.1016/0092-8674(95)90331-3. PMID 7736573. S2CID 19024872.
- Nakamura T, Largaespada DA, Lee MP, Johnson LA, Ohyashiki K, Toyama K, Chen SJ, Willman CL, Chen IM, Feinberg AP, Jenkins NA, Copeland NG, Shaughnessy JD (1996). "Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia". Nat. Genet. 12 (2): 154–8. doi:10.1038/ng0296-154. PMID 8563753. S2CID 6400265.
- Borrow J, Shearman AM, Stanton VP, Becher R, Collins T, Williams AJ, Dubé I, Katz F, Kwong YL, Morris C, Ohyashiki K, Toyama K, Rowley J, Housman DE (1996). "The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9". Nat. Genet. 12 (2): 159–67. doi:10.1038/ng0296-159. PMID 8563754. S2CID 21252465.
- Hu T, Guan T, Gerace L (1996). "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins". J. Cell Biol. 134 (3): 589–601. doi:10.1083/jcb.134.3.589. PMC 2120945. PMID 8707840.
- Stutz F, Izaurralde E, Mattaj IW, Rosbash M (1996). "A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus". Mol. Cell. Biol. 16 (12): 7144–50. doi:10.1128/mcb.16.12.7144. PMC 231718. PMID 8943370.
- Yaseen NR, Blobel G (1997). "Cloning and characterization of human karyopherin beta3". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4451–6. Bibcode:1997PNAS...94.4451Y. doi:10.1073/pnas.94.9.4451. PMC 20743. PMID 9114010.
- Bonifaci N, Moroianu J, Radu A, Blobel G (1997). "Karyopherin beta2 mediates nuclear import of a mRNA binding protein". Proc. Natl. Acad. Sci. U.S.A. 94 (10): 5055–60. Bibcode:1997PNAS...94.5055B. doi:10.1073/pnas.94.10.5055. PMC 24630. PMID 9144189.
- Grandi P, Dang T, Pané N, Shevchenko A, Mann M, Forbes D, Hurt E (1997). "Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly". Mol. Biol. Cell. 8 (10): 2017–38. doi:10.1091/mbc.8.10.2017. PMC 25664. PMID 9348540.
- Zolotukhin AS, Felber BK (1999). "Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev". J. Virol. 73 (1): 120–7. doi:10.1128/JVI.73.1.120-127.1999. PMC 103815. PMID 9847314.
- Kasper LH, Brindle PK, Schnabel CA, Pritchard CE, Cleary ML, van Deursen JM (1999). "CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity". Mol. Cell. Biol. 19 (1): 764–76. doi:10.1128/mcb.19.1.764. PMC 83933. PMID 9858599.
- Fontoura BM, Blobel G, Matunis MJ (1999). "A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96". J. Cell Biol. 144 (6): 1097–112. doi:10.1083/jcb.144.6.1097. PMC 2150585. PMID 10087256.
- Pritchard CE, Fornerod M, Kasper LH, van Deursen JM (1999). "RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains". J. Cell Biol. 145 (2): 237–54. doi:10.1083/jcb.145.2.237. PMC 2133102. PMID 10209021.
- Ahuja HG, Felix CA, Aplan PD (1999). "The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion". Blood. 94 (9): 3258–61. doi:10.1182/blood.V94.9.3258. PMID 10556215.
- Bachi A, Braun IC, Rodrigues JP, Panté N, Ribbeck K, von Kobbe C, Kutay U, Wilm M, Görlich D, Carmo-Fonseca M, Izaurralde E (2000). "The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates". RNA. 6 (1): 136–58. doi:10.1017/S1355838200991994. PMC 1369901. PMID 10668806.
- Fontoura BM, Blobel G, Yaseen NR (2000). "The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import". J. Biol. Chem. 275 (40): 31289–96. doi:10.1074/jbc.M004651200. PMID 10875935.
- Rodrigues JP, Sitterlin D, Bachi A, Wu X, Wilm M, Carmo-Fonseca M, Izaurralde E (2000). "Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin Nup98". Mol. Cell. 6 (5): 1243–52. doi:10.1016/S1097-2765(00)00120-9. PMID 11106761.
- Hofmann W, Reichart B, Ewald A, Müller E, Schmitt I, Stauber RH, Lottspeich F, Jockusch BM, Scheer U, Hauber J, Dabauvalle MC (2001). "Cofactor requirements for nuclear export of Rev response element (RRE)- and constitutive transport element (CTE)-containing retroviral RNAs. An unexpected role for actin". J. Cell Biol. 152 (5): 895–910. doi:10.1083/jcb.152.5.895. PMC 2198816. PMID 11238447.
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