프레사토비르

Presatovir
프레사토비르
Presatovir structure.png
임상자료
상명프레사토비르
법적현황
법적현황
식별자
  • N-[2-[(2S)-2-[5-[(3S)-3-아미노피롤리딘-1-yl]-6-메틸피라졸로[1,5-a]피리미딘-2-yl]피페리딘-1-카르보닐]-4-클로로페닐]메타네술폰아미드
CAS 번호
펍켐 CID
유니
화학 및 물리적 데이터
공식C24H30CLN7O3S
어금질량532.1 g·192−1
3D 모델(JSmol)
  • CC1=CN2C(=CC(=N2)[C@@H]3CCCCN3C(=O)C4=C(C=CC(=C4)Cl)NS(=O)C)N=C1N5CC[C@@H](C5)N
  • InChI=1S/C24H30ClN7O3S/c1-15-13-32-22(27-23(15)30-10-8-17(26)14-30)12-20(28-32)21-5-3-4-9-31(21)24(33)18-11-16(25)6-7-19(18)29-36(2,34)35/h6-7,11-13,17,21,29H,3-5,8-10,14,26H2,1-2H3/t17-,21-/m0/s1
  • 키:GOFXWTVKPWJNGD-UWJYQICSA-N

프레사토비르(GS-5806)는 호흡기세포융합바이러스 치료제로 개발된 항바이러스제다.[1][2]융해 억제제 역할을 하며, 임상 2상에서도 유망한 결과를 보여 왔다.[3][4]

참고 항목

참조

  1. ^ Mackman RL, Sangi M, Sperandio D, Parrish JP, Eisenberg E, Perron M, et al. (February 2015). "Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study". Journal of Medicinal Chemistry. 58 (4): 1630–1643. doi:10.1021/jm5017768. PMID 25574686.
  2. ^ Yamaguchi-Sasaki T, Tamura Y, Ogata Y, Kawaguchi T, Kurosaka J, Sugaya Y, et al. (2020). "Design and Synthesis of 2-(1-Alkylaminoalkyl)pyrazolo[1,5-a]pyrimidines as New Respiratory Syncytial Virus Fusion Protein Inhibitors". Chemical & Pharmaceutical Bulletin. 68 (4): 345–362. doi:10.1248/cpb.c19-00895. PMID 32238652.
  3. ^ Marty FM, Chemaly RF, Mullane KM, Lee DG, Hirsch HH, Small CB, et al. (December 2019). "A Phase 2b, Randomized, Double-blind, Placebo-Controlled Multicenter Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of Presatovir in Hematopoietic Cell Transplant Recipients with Respiratory Syncytial Virus (RSV) Infection of the Lower Respiratory Tract". Clinical Infectious Diseases. doi:10.1093/cid/ciz1167. PMID 31915807.
  4. ^ Stray K, Perron M, Porter DP, Anderson F, Lewis SA, Perry J, et al. (January 2020). "Drug resistance assessment following administration of RSV fusion inhibitor presatovir to participants experimentally infected with respiratory syncytial virus". The Journal of Infectious Diseases. doi:10.1093/infdis/jiaa028. PMID 31971597.
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