호모사피엔스 종의 단백질 코딩 유전자
감마-아미노부티산 수용체 하위단위 세타는 인간에서 GABRQ 유전자에 의해 암호화된 단백질이다.[5][6]이 유전자에 의해 인코딩된 단백질은 GAB의 서브 유닛이다.AA 수용체.
θ 서브유닛은 β1 서브유닛과 가장 높은 시퀀스 유사성을 가진다.[6]이 횡단구성요소는 다음과 같이 조합된다.
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000268089 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000031344 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Sinkkonen ST, Hanna MC, Kirkness EF, Korpi ER (15 May 2000). "GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus". J. Neurosci. 20 (10): 3588–3595. doi:10.1523/jneurosci.20-10-03588.2000. PMC 6772669. PMID 10804200.
- ^ a b c Bonnert TP, McKernan RM, Farrar S, le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ (August 1999). "θ, a novel γ-aminobutyric acid type A receptor subunit". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9891–9896. Bibcode:1999PNAS...96.9891B. doi:10.1073/pnas.96.17.9891. PMC 22306. PMID 10449790.
- ^ a b Ranna M, Sinkkonen ST, Möykkynen T, Uusi-Oukari M, Korpi ER (2006). "Impact of ε and θ subunits on pharmacological properties of α3β1 GABAA receptors expressed in Xenopus oocytes". BMC Pharmacol. 6: 1. doi:10.1186/1471-2210-6-1. PMC 1363348. PMID 16412217.
추가 읽기
- Whiting PJ, Bonnert TP, McKernan RM, et al. (1999). "Molecular and functional diversity of the expanding GABA-A receptor gene family". Ann. N. Y. Acad. Sci. 868 (1): 645–653. Bibcode:1999NYASA.868..645W. doi:10.1111/j.1749-6632.1999.tb11341.x. PMID 10414349. S2CID 13130259.
- Craddock N, Jones L, Jones IR, et al. (2010). "Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype". Mol. Psychiatry. 15 (2): 146–153. doi:10.1038/mp.2008.66. PMC 3967096. PMID 19078961.
- Sinkkonen ST, Hanna MC, Kirkness EF, Korpi ER (2000). "GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus". J. Neurosci. 20 (10): 3588–3595. doi:10.1523/jneurosci.20-10-03588.2000. PMC 6772669. PMID 10804200.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–816. doi:10.1002/ajmg.b.30902. PMID 19086053.
- Bonnert TP, McKernan RM, Farrar S, et al. (1999). "θ, a novel γ-aminobutyric acid type A receptor subunit". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9891–9896. Bibcode:1999PNAS...96.9891B. doi:10.1073/pnas.96.17.9891. PMC 22306. PMID 10449790.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Fernandez F, Esposito T, Lea RA, et al. (2008). "Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility". BMC Med. Genet. 9: 109. doi:10.1186/1471-2350-9-109. PMC 2615754. PMID 19087248.
- Tabakoff B, Saba L, Printz M, et al. (2009). "Genetical genomic determinants of alcohol consumption in rats and humans". BMC Biol. 7: 70. doi:10.1186/1741-7007-7-70. PMC 2777866. PMID 19874574.
외부 링크
