RAS p21 단백질 활성제 1

RAS p21 protein activator 1
라사1
Protein RASA1 PDB 1wer.png
사용 가능한 구조물
PDB직교 검색: PDBe RCSB
식별자
별칭RASA1, CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP, RAS p21 단백질 활성제 1,120, CMAVM1
외부 IDOMIM: 139150 MGI: 97860 HomoloGene: 2168 GeneCard: RASA1
직교체
종인간마우스
엔트레스

5921

218397

앙상블

ENSG00000145715

ENSMUSG00000021549

유니프로트

P20936

E9PYG6

RefSeq(mRNA)

NM_002890
NM_022650

NM_145452

RefSeq(단백질)

NP_002881
NP_072179

NP_663427

위치(UCSC)Cr 5: 87.27 – 87.39MbChr 13: 85.36 – 85.44Mb
PubMed 검색[3][4]
위키다타
인간 보기/편집마우스 보기/편집

RAS p21 단백질 활성제 1 또는 RasGAP(Ras GTPase 활성화 단백질)은 RASA1이라고도 알려진 120kDa 세포질 인간 단백질로, 다음과 같은 두 가지 주요 활동을 제공한다.

  • C-단자 GAP 도메인을 통해 Ras의 내인성 GTPase 활동을 개선하여 Ras의 활성 GTP-bound 형식에서 비활성 GDP-bound 형식으로의 비활성화
  • N-터미널 SH2-SH3-SH2 도메인을 통해 다운스트림 상호 작용하는 파트너를 향한 미토제닉 신호 전송

이 유전자에 의해 인코딩된 단백질은 세포질에 위치하며 GTPase 활성화 단백질의 GAP1 계열의 일부다.유전자 생산물은 일반 RAS p21의 GTPase 활성을 자극하지만, 그것의 종양 유발 상대는 자극하지 않는다.RAS 기능의 억제제 역할을 하는 이 단백질은 RAS 단백질의 약한 내인성 GTPase 활성을 강화하여 RAS의 GDP-경계형태를 비활성으로 만들어 세포 증식과 분화를 제어할 수 있게 한다.어느 한 단백질의 결합 부위의 변화를 이끄는 돌연변이는 기저 세포암과 관련이 있다.대체 스플라이싱은 N단자 소수성 부위는 부족하지만 동일한 활동을 유지하는 짧은 등소형태가 성인조직은 아닌 태반으로 풍부하게 표현되는 두 개의 등소형을 만든다.[5]

도메인

RasGAP에는 SH3 도메인 1개와 SH2 도메인 2개, PH 도메인 1개, C2 도메인, GAP 도메인이 있다.

상호작용

RAS p21 단백질 활성제 1은 다음과 상호작용하는 것으로 나타났다.

mRNA는 Mir-132 microRNA와 상호작용할 수 있다; 이 과정은 혈관신생과 연결되어 있다.[32]

질병 데이터베이스

RASA1 유전자 변종 데이터베이스

참조

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