RGS4
RGS4
RGP4로도 알려진 G단백질신호 4의 조절기는 인간에서 RGS4 유전자에 의해 암호화된 단백질이다.RGP4는 G단백질신호를 조절한다.[5]
함수
G 단백질 신호전달(RGS) 계열 구성원의 조절기는 이질 G 단백질의 G 알파 서브유닛에 대해 GTPase 활성화 단백질(GAPs)의 역할을 하는 규제 분자다.[6]RGS 단백질은 Gi 알파, Go 알파, Gq 알파 아형의 G 단백질 서브유닛을 비활성화할 수 있다.그들은 G 단백질을 그들의 활동적이지 않은 GDP에 묶인 형태로 유도한다.G단백질신호4의 조절기는 이 계열에 속한다.모든 RGS 단백질은 GAP 활동을 전달하는 RGS 영역이라고 불리는 보존된 120-아미노산 염기서열을 공유한다.[7]G단백질 신호 4단백질 조절기는 RGS1과 37%, 랫드 Rgs4와 97% 동일하다.이 단백질은 신호 업스트림 또는 이질 G 단백질의 수준에서 신호를 부정적으로 조절하며 세포질 내에 국부화된다.[5]
임상적 유의성
많은 연구들이 RGS4 유전자를 정신분열증과 연관시키는 반면 일부는 연관성을 발견하지 못한다.[8][9][10][11][12]
RGS4는 뮤 오피오이드 수용체에 의한 신호 전달을 종료하는 데 관여하는 3가지 주요 RGS 단백질(RGS9 및 RGS17과 함께) 중 하나로도 관심이 있으며,[13] 오피오이드 약물에 대한 내성 개발에 중요할 수 있다.[14][15][16][17][18]
억제제
상호작용
RGS4는 다음과 상호 작용하는 것으로 나타났다.
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000117152 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000038530 - 앙상블, 2017년 5월
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- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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추가 읽기
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