RGS12

RGS12
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2EBZ, 2KV8
식별자
에일리어스	RGS12, G단백질신호조절제12
외부 ID	OMIM: 602512 MGI: 1918979 HomoloGene: 2195 GenCard: RGS12
유전자 위치(인간)
크르.	4번 염색체(인간)
끝.	3,439,913 bp
유전자 위치(마우스)
크르.	5번 염색체(쥐)
끝.	35,194,988 bp
RNA발현패턴
	상단 표시 위치:
	신경절 융기; ; 우측 자궁관; ; 복부 피부; ; 전전두피질; ; 대상회; ; 질; ; 간우엽; ; 핵액컴벤스; ; 위점막; ; 창호;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	GO:0005083 GTPase 레귤레이터 액티비티; GO:0005097, GO:0005099, GO:0005100 GTPase 액티베이터 액티베이션; GO:0006184 GTPase 액티비티;
셀룰러 컴포넌트	세포질; 세포 투영; 핵매트릭스; 시냅스; 축합핵염색체; 세포 접합; 수상돌기; 혈장막; 핵; 핵소체; 세포;
생물학적 과정	G단백질결합수용체신호경로조절; 전사, DNA 템플릿; GO:0032320, GO:00321, GO:0032855, GO:0043089, GO:0032854 GTPase 액티비티의 플러스 레귤레이션; 신호 전달의 음성 조절; 신호 변환; GO:0048552 촉매 활성 조절; G단백질결합수용체신호경로;
	출처:아미고 / QuickGO
맞춤법
	6002
	71729
	ENSG00000159788
	ENSMUSG000029101
	O14924
	Q8CGE9
NM_002926; NM_198227; NM_198229; NM_198230; NM_198430;
	NM_198432; NM_198587; NM_001394154; NM_001394155; NM_001394156; NM_001394157; NM_001394158; NM_001394159; NM_001394161; NM_001394162; NM_001394163
	NM_001163512; NM_173402
	NP_002917; NP_937870; NP_937872
NP_001156984; NP_775578; NP_001390400; NP_001390401; NP_001390402;
	NP_001390403; NP_001390404; NP_001390405; NP_001390406; NP_001390407
	위키데이터
인간 보기/편집	마우스 표시/편집

G단백질 시그널링 12의 조절제는 RGS12 ^[5]^[6]유전자에 의해 인체 내에서 부호화되는 단백질이다.

이 유전자는 'G단백질신호조절기(RGS)' 유전자 패밀리의 일원을 암호화한다.코드화된 단백질은 구아노신 트리포스파타아제(GTPAase) 활성화 단백질 및 전사억제제로 기능할 수 있다.이 단백질은 종양 발생에 역할을 할 수 있다.이 유전자에 대해 별개의 등형질을 코드하는 복수의 전사 변이가 확인되었다.다른 대체 스플라이스 변형이 설명되었지만 생물학적 특성은 확인되지 ^[6]않았다.

상호 작용

RGS12는 GNI1,^[7] GNI3,^[7] 카파 오피오이드 ^[8]수용체와 상호작용하는 것으로 나타났다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000159788 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000029101 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (August 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J Biol Chem. 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375.
^ ^a ^b "Entrez Gene: RGS12 regulator of G-protein signalling 12".
^ ^a ^b Kimple, R J; De Vries L; Tronchère H; Behe C I; Morris R A; Gist Farquhar M; Siderovski D P (August 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. ISSN 0021-9258. PMID 11387333.
^ Gross, JD; Kaski, SW; Schmidt, KT; Cogan, ES; Boyt, KM; Wix, K; Schroer, AB; McElligott, ZA; Siderovski, DP; Setola, V (September 2019). "Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior". Neuropsychopharmacology. 44 (10): 1728–1741. doi:10.1038/s41386-019-0423-7. PMC 6785087. PMID 31141817.

추가 정보

Frohme M, Scharm B, Delius H, et al. (2000). "Use of representational difference analysis and cDNA arrays for transcriptional profiling of tumor tissue". Ann. N. Y. Acad. Sci. 910 (1): 85–104, discussion 104–5. Bibcode:2000NYASA.910...85F. doi:10.1111/j.1749-6632.2000.tb06703.x. PMID 10911908. S2CID 25399395.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Snow BE, Antonio L, Suggs S, et al. (1997). "Molecular cloning and expression analysis of rat Rgs12 and Rgs14". Biochem. Biophys. Res. Commun. 233 (3): 770–7. doi:10.1006/bbrc.1997.6537. PMID 9168931.
Chatterjee TK, Fisher RA (2000). "Novel alternative splicing and nuclear localization of human RGS12 gene products". J. Biol. Chem. 275 (38): 29660–71. doi:10.1074/jbc.M000330200. PMID 10869340.
Schiff ML, Siderovski DP, Jordan JD, et al. (2001). "Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel". Nature. 408 (6813): 723–7. doi:10.1038/35047093. PMID 11130074. S2CID 205011654.
Kimple RJ, De Vries L, Tronchère H, et al. (2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. PMID 11387333.
Snow BE, Brothers GM, Siderovski DP (2002). "Molecular Cloning of Regulators of G-Protein Signaling Family Members and Characterization of Binding Specificity of RGS 12 PDZ Domain". Molecular cloning of regulators of G-protein signaling family members and characterization of binding specificity of RGS12 PDZ domain. Meth. Enzymol. Methods in Enzymology. Vol. 344. pp. 740–61. doi:10.1016/S0076-6879(02)44752-0. ISBN 9780121822453. PMID 11771424.
Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488.
Chatterjee TK, Fisher RA (2002). "RGS12TS-S localizes at nuclear matrix-associated subnuclear structures and represses transcription: structural requirements for subnuclear targeting and transcriptional repression". Mol. Cell. Biol. 22 (12): 4334–45. doi:10.1128/MCB.22.12.4334-4345.2002. PMC 133853. PMID 12024043.
Potocnik U, Glavac D, Ravnik-Glavac M (2003). "Identification of novel genes with somatic frameshift mutations within coding mononucleotide repeats in colorectal tumors with high microsatellite instability". Genes Chromosomes Cancer. 36 (1): 48–56. doi:10.1002/gcc.10141. PMID 12461749. S2CID 30132562.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Yang S, Li YP (2007). "RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro". J. Bone Miner. Res. 22 (1): 45–54. doi:10.1359/jbmr.061007. PMC 3559086. PMID 17042716.
Gross, J. D.; Kaski, S. W.; Schroer, A. B.; Wix, K. A.; Siderovski, D. P.; Setola, V. (2018). "Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants". J. Psychopharmacol. 32 (2): 191–203. doi:10.1177/0269881117742100. PMC 5942192. PMID 29364035.
Gross, Joshua D.; Kaski, Shane W.; Schmidt, Karl T.; Cogan, Elizabeth S.; Boyt, Kristen M.; Wix, Kim; Schroer, Adam B.; McElligott, Zoe A.; Siderovski, David P. (2019-05-29). "Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior". Neuropsychopharmacology. 44 (10): 1728–1741. doi:10.1038/s41386-019-0423-7. ISSN 1740-634X. PMC 6785087. PMID 31141817.
Schroer, AB; Mohamed, JS; Willard, MD; Setola, V; Oestreich, E; Siderovski, DP (2019). "A role for Regulator of G protein Signaling-12 (RGS12) in the balance between myoblast proliferation and differentiation". PLOS ONE. 14 (8): e0216167. Bibcode:2019PLoSO..1416167S. doi:10.1371/journal.pone.0216167. PMC 6691989. PMID 31408461.

인간 염색체 4번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000159788 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000029101 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9651375-5] Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (August 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J Biol Chem. 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375.

[entrez-6] "Entrez Gene: RGS12 regulator of G-protein signalling 12".

[pmid11387333-7] Kimple, R J; De Vries L; Tronchère H; Behe C I; Morris R A; Gist Farquhar M; Siderovski D P (August 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. ISSN 0021-9258. PMID 11387333.

[8] Gross, JD; Kaski, SW; Schmidt, KT; Cogan, ES; Boyt, KM; Wix, K; Schroer, AB; McElligott, ZA; Siderovski, DP; Setola, V (September 2019). "Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior". Neuropsychopharmacology. 44 (10): 1728–1741. doi:10.1038/s41386-019-0423-7. PMC 6785087. PMID 31141817.

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RGS12

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상호 작용

레퍼런스

추가 정보