RGS19

RGS19
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1CMZ
식별자
에일리어스	RGS19, GAIP, RGSGAIP, G단백질 시그널링 19의 조절기, G단백질 시그널링 19의 조절기
외부 ID	OMIM: 605071 MGI: 1915153 HomoloGene: 23320 GenCard: RGS19
유전자 위치(인간)
크르.	20번 염색체(인간)
끝.	64,079,988 bp
유전자 위치(마우스)
크르.	2번 염색체(마우스)
끝.	181,335,770 bp
RNA발현패턴
	상단 표시 위치:
	피; ; 단구; ; 비장; ; 골수 세포; ; 이하선; ; 결석골; ; 림프절; ; 양수; ; 부록; ; 우관상 동맥;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	GO:0005097, GO:0005099, GO:0005100 GTPase 액티베이터 액티베이션; GO:0001948, GO:0016582 단백질 결합; G단백질α-서브유닛결합; GO:0006184 GTPase 액티비티;
셀룰러 컴포넌트	세포질; 골지 장치; 막; 브러시 테두리; 헤테로 이성질 G단백질복합체; 막보트; 클라트린 소포; GO:0016023 세포질 소포; 혈장막;
생물학적 과정	G단백질결합수용체신호경로; GTPase 매개 신호 전달; 오토파지; 신호 전달의 음성 조절; GO:0032320, GO:00321, GO:0032855, GO:0043089, GO:0032854 GTPase 액티비티의 플러스 레귤레이션; 에탄올에 대한 반응;
	출처:아미고 / QuickGO
맞춤법
	10287
	56470
	ENSG000001700
	ENSMUSG00000002458
	P49795
	Q9CX84
	NM_001039467; NM_005873
NM_001291205; NM_001291206; NM_001291207; NM_001291208; NM_001291209;
	NM_001291210; NM_026446
	NP_001034556; NP_005864
NP_001278134; NP_001278135; NP_001278136; NP_001278137; NP_001278138;
	NP_001278139; NP_080722
	위키데이터
인간 보기/편집	마우스 표시/편집

G단백질 시그널링 19의 조절제는 RGS19 ^[5]^[6]유전자에 의해 인체 내에서 부호화되는 단백질이다.

G단백질은 많은 세포과정을 매개한다.이 유전자에 의해 코드된 단백질은 RGS(G-단백질 시그널링 조절제) 계열에 속하며, 특히 G단백질인 GAI3와 상호작용한다.이 단백질은 구아노신 트리포스파타아제 활성화 단백질로 갈파 i/Galpha q-연결 신호를 하향 ^[6]^[7]조절하는 기능을 한다.

상호 작용

RGS19는 GNO1,^[8]^[9] GIPC1,^[10] OTM1,^[11] GNI1,^[8]^[9] GNI3^[5]^[8]^[9], ^[8]^[12]GNZ와 상호작용하는 것으로 나타났다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG000001700 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000002458 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b De Vries L, Mousli M, Wurmser A, Farquhar MG (January 1996). "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain". Proc Natl Acad Sci U S A. 92 (25): 11916–20. doi:10.1073/pnas.92.25.11916. PMC 40514. PMID 8524874.
^ ^a ^b "Entrez Gene: RGS19 regulator of G-protein signalling 19".
^ Berman DM, Wilkie TM, Gilman AG (1996). "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits". Cell. 86 (3): 445–452. doi:10.1016/S0092-8674(00)80117-8. PMID 8756726. S2CID 12427406.
^ ^a ^b ^c ^d De Vries, L; Elenko E; Hubler L; Jones T L; Farquhar M G (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 93 (26): 15203–8. Bibcode:1996PNAS...9315203D. doi:10.1073/pnas.93.26.15203. ISSN 0027-8424. PMC 26381. PMID 8986788.
^ ^a ^b ^c Woulfe, D S; Stadel J M (June 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". J. Biol. Chem. UNITED STATES. 274 (25): 17718–24. doi:10.1074/jbc.274.25.17718. ISSN 0021-9258. PMID 10364213.
^ Lou, X; Yano H; Lee F; Chao M V; Farquhar M G (March 2001). "GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways". Mol. Biol. Cell. United States. 12 (3): 615–27. doi:10.1091/mbc.12.3.615. ISSN 1059-1524. PMC 30968. PMID 11251075.
^ Fischer, Thierry; De Vries Luc; Meerloo Timo; Farquhar Marilyn Gist (July 2003). "Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP". Proc. Natl. Acad. Sci. U.S.A. United States. 100 (14): 8270–5. Bibcode:2003PNAS..100.8270F. doi:10.1073/pnas.1432965100. ISSN 0027-8424. PMC 166218. PMID 12826607.
^ Fan, X; Brass L F; Poncz M; Spitz F; Maire P; Manning D R (October 2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". J. Biol. Chem. UNITED STATES. 275 (41): 32129–34. doi:10.1074/jbc.M004577200. ISSN 0021-9258. PMID 10906137.

추가 정보

Berman DM, Wilkie TM, Gilman AG (1996). "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits". Cell. 86 (3): 445–452. doi:10.1016/S0092-8674(00)80117-8. PMID 8756726. S2CID 12427406.
De Vries L, Elenko E, Hubler L, et al. (1997). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15203–8. Bibcode:1996PNAS...9315203D. doi:10.1073/pnas.93.26.15203. PMC 26381. PMID 8986788.
Ogier-Denis E, Petiot A, Bauvy C, Codogno P (1997). "Control of the expression and activity of the Galpha-interacting protein (GAIP) in human intestinal cells". J. Biol. Chem. 272 (39): 24599–603. doi:10.1074/jbc.272.39.24599. PMID 9305927.
De Vries L, Elenko E, McCaffery JM, et al. (1998). "RGS-GAIP, a GTPase-activating protein for Galphai heterotrimeric G proteins, is located on clathrin-coated vesicles". Mol. Biol. Cell. 9 (5): 1123–34. doi:10.1091/mbc.9.5.1123. PMC 25334. PMID 9571244.
Popov S, Yu K, Kozasa T, Wilkie TM (1997). "The regulators of G protein signaling (RGS) domains of RGS4, RGS10 and GAIP retain GTPase activating protein activity in vitro". Proc Natl Acad Sci USA. 94 (14): 7216–20. Bibcode:1997PNAS...94.7216P. doi:10.1073/pnas.94.14.7216. PMC 23796. PMID 9207071.
Wang J, Ducret A, Tu Y, et al. (1998). "RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily". J. Biol. Chem. 273 (40): 26014–25. doi:10.1074/jbc.273.40.26014. PMID 9748280.
De Vries L, Lou X, Zhao G, et al. (1998). "GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP". Proc. Natl. Acad. Sci. U.S.A. 95 (21): 12340–5. Bibcode:1998PNAS...9512340D. doi:10.1073/pnas.95.21.12340. PMC 22833. PMID 9770488.
Fischer T, Elenko E, McCaffery JM, et al. (1999). "Clathrin-coated vesicles bearing GAIP possess GTPase-activating protein activity in vitro". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6722–7. Bibcode:1999PNAS...96.6722F. doi:10.1073/pnas.96.12.6722. PMC 21982. PMID 10359779.
Woulfe DS, Stadel JM (1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". J. Biol. Chem. 274 (25): 17718–24. doi:10.1074/jbc.274.25.17718. PMID 10364213.
de Alba E, De Vries L, Farquhar MG, Tjandra N (1999). "Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling". J. Mol. Biol. 291 (4): 927–39. doi:10.1006/jmbi.1999.2989. PMID 10452897.
Zheng B, Chen D, Farquhar MG (2000). "MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 3999–4004. Bibcode:2000PNAS...97.3999Z. doi:10.1073/pnas.97.8.3999. PMC 18131. PMID 10760272.
Fischer T, Elenko E, Wan L, et al. (2000). "Membrane-associated GAIP is a phosphoprotein and can be phosphorylated by clathrin-coated vesicles". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4040–5. Bibcode:2000PNAS...97.4040F. doi:10.1073/pnas.97.8.4040. PMC 18141. PMID 10760275.
Ogier-Denis E, Pattingre S, El Benna J, Codogno P (2001). "Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells". J. Biol. Chem. 275 (50): 39090–5. doi:10.1074/jbc.M006198200. PMID 10993892.
Ito E, Xie G, Maruyama K, Palmer PP (2000). "A core-promoter region functions bi-directionally for human opioid-receptor-like gene ORL1 and its 5'-adjacent gene GAIP". J. Mol. Biol. 304 (3): 259–70. doi:10.1006/jmbi.2000.4212. PMID 11090272.
Lou X, Yano H, Lee F, et al. (2001). "GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways". Mol. Biol. Cell. 12 (3): 615–27. doi:10.1091/mbc.12.3.615. PMC 30968. PMID 11251075.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Ross EM, Wilkie TM (2000). "GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins". Annual Review of Biochemistry. 69: 795–827. doi:10.1146/annurev.biochem.69.1.795. PMID 10966476.
Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, Barker SA, He W, Wensel TG, Otero G, Brown G, Copeland NG, Jenkins NA, Wilkie TM (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488.
Kirikoshi H, Katoh M (2002). "Expression of human GIPC1 in normal tissues, cancer cell lines, and primary tumors". Int. J. Mol. Med. 9 (5): 509–13. doi:10.3892/ijmm.9.5.509. PMID 11956658.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Xie GX, Han X, Ito E, et al. (2003). "Gene structure, dual-promoters and mRNA alternative splicing of the human and mouse regulator of G protein signaling GAIP/RGS19". J. Mol. Biol. 325 (4): 721–32. doi:10.1016/S0022-2836(02)01283-4. PMID 12507475.
Fischer T, De Vries L, Meerloo T, Farquhar MG (2003). "Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8270–5. Bibcode:2003PNAS..100.8270F. doi:10.1073/pnas.1432965100. PMC 166218. PMID 12826607.

외부 링크

UCSC Genome Browser의 RGS19 인간 유전자 위치.
UCSC Genome Browser의 RGS19 인간 유전자 상세.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG000001700 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG00000002458 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8524874-5] De Vries L, Mousli M, Wurmser A, Farquhar MG (January 1996). "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain". Proc Natl Acad Sci U S A. 92 (25): 11916–20. doi:10.1073/pnas.92.25.11916. PMC 40514. PMID 8524874.

[entrez-6] "Entrez Gene: RGS19 regulator of G-protein signalling 19".

[7] Berman DM, Wilkie TM, Gilman AG (1996). "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits". Cell. 86 (3): 445–452. doi:10.1016/S0092-8674(00)80117-8. PMID 8756726. S2CID 12427406.

[pmid8986788-8] De Vries, L; Elenko E; Hubler L; Jones T L; Farquhar M G (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 93 (26): 15203–8. Bibcode:1996PNAS...9315203D. doi:10.1073/pnas.93.26.15203. ISSN 0027-8424. PMC 26381. PMID 8986788.

[pmid10364213-9] Woulfe, D S; Stadel J M (June 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". J. Biol. Chem. UNITED STATES. 274 (25): 17718–24. doi:10.1074/jbc.274.25.17718. ISSN 0021-9258. PMID 10364213.

[pmid11251075-10] Lou, X; Yano H; Lee F; Chao M V; Farquhar M G (March 2001). "GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways". Mol. Biol. Cell. United States. 12 (3): 615–27. doi:10.1091/mbc.12.3.615. ISSN 1059-1524. PMC 30968. PMID 11251075.

[pmid12826607-11] Fischer, Thierry; De Vries Luc; Meerloo Timo; Farquhar Marilyn Gist (July 2003). "Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP". Proc. Natl. Acad. Sci. U.S.A. United States. 100 (14): 8270–5. Bibcode:2003PNAS..100.8270F. doi:10.1073/pnas.1432965100. ISSN 0027-8424. PMC 166218. PMID 12826607.

[pmid10906137-12] Fan, X; Brass L F; Poncz M; Spitz F; Maire P; Manning D R (October 2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". J. Biol. Chem. UNITED STATES. 275 (41): 32129–34. doi:10.1074/jbc.M004577200. ISSN 0021-9258. PMID 10906137.

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RGS19

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상호 작용

레퍼런스

추가 정보

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