호모 사피엔스 종의 단백질 코드 유전자
도킹단백질 1은 인간 의 몸에 있는 단백질 로 DOK1 [5] [6] [7]
기능. 도킹단백질1은 만성상 만성골수성백혈병(CML) 환자로부터 분리된 조혈성 전구체에서 인산화되는 구성 티로신이다. CML과 관련된 키메라 단백질인 p210(bcr/abl)의 중요한 기질일 수 있다.도킹 단백질 1은 아미노 말단에서의 추정 플렉스트린 호몰로지 도메인과 10개의 PXP SH3 인식 모티브를 포함한다. 도킹 단백질 2는 CML 세포에서 p120(RasGAP)을 결합한다. 그것은 유사분열 신호 [8]
상호 작용 DOK1은 다음과 상호작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000115325 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000068335 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Carpino N, Wisniewski D, Strife A, Marshak D, Kobayashi R, Stillman B, Clarkson B (February 1997). "p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells" . Cell . 88 (2): 197–204. doi :10.1016/S0092-8674(00)81840-1 PMID 9008160 . S2CID 16781519 . ^ Nelms K, Snow AJ, Noben-Trauth K (December 1998). "Dok1 encoding p62(dok) maps to mouse chromosome 6 and human chromosome 2 in a region of translocation in chronic lymphocytic leukemia" . Genomics . 53 (2): 243–5. doi :10.1006/geno.1998.5514 . PMID 9790776 . ^ Ling Y, Maile LA, Badley-Clarke J, Clemmons DR (February 2005). "DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells" . J. Biol. Chem . 280 (5): 3151–8. doi :10.1074/jbc.M411035200 PMID 15546884 . ^ "Entrez Gene: DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)" .^ a b c d van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M (November 2000). "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells". Blood . 96 (10): 3406–13. doi :10.1182/blood.V96.10.3406 . PMID 11071635 . ^ a b Yamanashi Y, Baltimore D (January 1997). "Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok" . Cell . 88 (2): 205–11. doi :10.1016/s0092-8674(00)81841-3 PMID 9008161 . S2CID 14205526 . ^ a b c Liang X, Wisniewski D, Strife A, Clarkson B, Resh MD (April 2002). "Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling" . J. Biol. Chem . 277 (16): 13732–8. doi :10.1074/jbc.M200277200 PMID 11825908 . ^ a b c Dunant NM, Wisniewski D, Strife A, Clarkson B, Resh MD (May 2000). "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells". Cell. Signal . 12 (5): 317–26. doi :10.1016/s0898-6568(00)00073-5 . PMID 10822173 . ^ Némorin JG, Duplay P (May 2000). "Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling" . J. Biol. Chem . 275 (19): 14590–7. doi :10.1074/jbc.275.19.14590 PMID 10799545 . ^ Murakami H, Yamamura Y, Shimono Y, Kawai K, Kurokawa K, Takahashi M (September 2002). "Role of Dok1 in cell signaling mediated by RET tyrosine kinase" . J. Biol. Chem . 277 (36): 32781–90. doi :10.1074/jbc.M202336200 PMID 12087092 . ^ Sylla BS, Murphy K, Cahir-McFarland E, Lane WS, Mosialos G, Kieff E (June 2000). "The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B" . Proc. Natl. Acad. Sci. U.S.A . 97 (13): 7470–5. doi :10.1073/pnas.130193097 PMC 16569 PMID 10852966 . 추가 정보 Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Wisniewski D, Strife A, Wojciechowicz D, Lambek C, Clarkson B (1994). "A 62-kilodalton tyrosine phosphoprotein constitutively present in primary chronic phase chronic myelogenous leukemia enriched lineage negative blast populations". Leukemia . 8 (4): 688–93. PMID 8152267 . Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem . 236 (1): 107–13. doi :10.1006/abio.1996.0138 . PMID 8619474 . Yamanashi Y, Baltimore D (1997). "Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok" . Cell . 88 (2): 205–11. doi :10.1016/S0092-8674(00)81841-3 PMID 9008161 . S2CID 14205526 . Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing" . Genome Res . 7 (4): 353–8. doi :10.1101/gr.7.4.353 . PMC 139146 PMID 9110174 . Vuica M, Desiderio S, Schneck JP (1997). "Differential effects of B cell receptor and B cell receptor-FcgammaRIIB1 engagement on docking of Csk to GTPase-activating protein (GAP)-associated p62" . J. Exp. Med . 186 (2): 259–67. doi :10.1084/jem.186.2.259 . PMC 2198989 PMID 9221755 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Chen M, She H, Davis EM, Spicer CM, Kim L, Ren R, Le Beau MM, Li W (1998). "Identification of Nck family genes, chromosomal localization, expression, and signaling specificity" . J. Biol. Chem . 273 (39): 25171–8. doi :10.1074/jbc.273.39.25171 PMID 9737977 . Noguchi T, Matozaki T, Inagaki K, Tsuda M, Fukunaga K, Kitamura Y, Kitamura T, Shii K, Yamanashi Y, Kasuga M (1999). "Tyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migration" . EMBO J . 18 (7): 1748–60. doi :10.1093/emboj/18.7.1748 . PMC 1171261 PMID 10202139 . Cong F, Yuan B, Goff SP (1999). "Characterization of a novel member of the DOK family that binds and modulates Abl signaling" . Mol. Cell. Biol . 19 (12): 8314–25. doi :10.1128/MCB.19.12.8314 . PMC 84915 PMID 10567556 . Berg KL, Siminovitch KA, Stanley ER (1999). "SHP-1 regulation of p62(DOK) tyrosine phosphorylation in macrophages" . J. Biol. Chem . 274 (50): 35855–65. doi :10.1074/jbc.274.50.35855 PMID 10585470 . Becker E, Huynh-Do U, Holland S, Pawson T, Daniel TO, Skolnik EY (2000). "Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation" . Mol. Cell. Biol . 20 (5): 1537–45. doi :10.1128/MCB.20.5.1537-1545.2000 . PMC 85333 PMID 10669731 . Némorin JG, Duplay P (2000). "Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling" . J. Biol. Chem . 275 (19): 14590–7. doi :10.1074/jbc.275.19.14590 PMID 10799545 . Dunant NM, Wisniewski D, Strife A, Clarkson B, Resh MD (2000). "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells". Cell. Signal . 12 (5): 317–26. doi :10.1016/S0898-6568(00)00073-5 . PMID 10822173 . Yoshida K, Yamashita Y, Miyazato A, Ohya K, Kitanaka A, Ikeda U, Shimada K, Yamanaka T, Ozawa K, Mano H (2000). "Mediation by the protein-tyrosine kinase Tec of signaling between the B cell antigen receptor and Dok-1" . J. Biol. Chem . 275 (32): 24945–52. doi :10.1074/jbc.M909012199 PMID 10823839 . Sylla BS, Murphy K, Cahir-McFarland E, Lane WS, Mosialos G, Kieff E (2000). "The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B" . Proc. Natl. Acad. Sci. U.S.A . 97 (13): 7470–5. doi :10.1073/pnas.130193097 PMC 16569 PMID 10852966 . Hubert P, Ferreira V, Debre P, Bismuth G (2000). "Molecular cloning of a truncated p62Dok1 isoform, p22Dok(del)". Eur. J. Immunogenet . 27 (3): 145–8. doi :10.1046/j.1365-2370.2000.00203.x . PMID 10940083 . Songyang Z, Yamanashi Y, Liu D, Baltimore D (2001). "Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling" (PDF) . J. Biol. Chem . 276 (4): 2459–65. doi :10.1074/jbc.M005504200 PMID 11042170 . S2CID 9752201 . 
