아포벡3C

아포벡3C
사용 가능한 구조
PDB	휴먼 유니프로트 검색: PDBe RCSB
PDB ID 코드 목록
	3VM8, 3VOW
식별자
에일리어스	APOBC3C, A3C, APOBC1L, ARDC2, ARDC4, ARP5, PBI, bK150C2.3, 아폴리포단백질BmRNA편집효소부단위 3C
외부 ID	OMIM : 607750 HomoloGene : 129856 GenCard : APOBCEC3C
유전자 위치(인간)
크르.	22번 염색체(인간)
끝.	39,020,352 bp
RNA발현패턴
	상단 표시 위치:
	단구; ; 림프절; ; 좌부신; ; 직장; ; 자궁내막간질세포; ; 평활근 조직; ; 이하선; ; 골수 세포; ; 피; ; 췌관 세포;
	추가 참조 표현식 데이터
	없음
유전자 존재론
분자 함수	GO:0001948 단백질 결합; 탄소-아미딘(펩타이드가 아닌) 결합에 작용하는 가수분해효소 활성, 고리형 아미딘; 촉매 활성; 아연 이온 결합; 가수분해효소활성; 금속 이온 결합; RNA결합; 시티딘탈아미나아제활성;
셀룰러 컴포넌트	핵; 세포질; P-바디;
생물학적 과정	바이러스 게놈 복제 음성 조절; 면역계 과정; 바이러스에 대한 방어 반응; 시티딘탈아미네이션; 선천성 면역 반응; GO:0022415 바이러스 처리; 전이의 음의 조절; DNA탈메틸화; 시티딘-우리딘 편집; 이중 가닥 DNA 중간체를 통한 단일 가닥 바이러스 RNA 복제 음성 조절; DNA시토신탈아미네이션;
	출처:아미고 / QuickGO
맞춤법
	27350
	없음
	ENSG00000244509
	없음
	Q9NRW3
	없음
	NM_014508
	없음
	NP_055323
	없음
	위키데이터
인간 보기/편집

DNA dC->dU 편집효소 APOBEC-3C는 사람에게서 APOBEC3C ^[3]^[4]유전자에 의해 코드되는 단백질이다.

A3C는 다양한 레트로바이러스에 대한 제한 인자로 작용하는 A3 계열의 시티딘 탈아미나아제에 속한다.A3C는 바이러스 감염인자 Vif가 ^[5]없는 경우 HIV-1보다는 Simian 면역결핍 바이러스를 효과적으로 억제하는 것으로 보고되었다.A3C의 촉매 활성을 증강하는 것은 HIV-1 복제에 미미한 영향(Vif가 없는 경우)을 미쳤을 뿐이며, 반응성 바이러스 메커니즘은 ^[6]불분명하다.A3C는 다른 ^[7]^[8]^[9]^[10]^[11]바이러스도 억제하는 것으로 나타났다.

기능.

이 유전자는 시티딘탈아미나아제 유전자의 일원이다.그것은 22번 염색체의 유전자 복제로 인해 발생하는 것으로 생각되는 클러스터에서 발견된 7개의 관련 유전자 또는 유사 유전자 중 하나이다.클러스터 구성원은 C to U RNA 편집 시티딘 탈아미나아제 APOBEC1과 구조적으로 기능적으로 관련된 단백질을 부호화한다.반대로 A3 단백질은 단일 가닥 DNA에 존재하는 ^[12]^[13]^[14]^[15]^[16]시티딘을 효소적으로 우리딘으로 변환한다.HIV-1에 대한 A3C의 항바이러스 활성을 결정하기 위해 A3C의 루프 1에 ^[17]있는 2개의 잔류물이 입증되었다.

구조.

A3C의 결정 구조는 추정 HIV-1 vif 결합 ^[18]^[19]영역을 나타냅니다.A3C는 탈아미나아제 비의존적 방식으로 ^[20]ORF1p 단백질과 직접 상호작용하여 LINE-1 요소를 억제하는 것으로 확인되었다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000244509 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jarmuz A, Chester A, Bayliss J, Gisbourne J, Dunham I, Scott J, Navaratnam N (March 2002). "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22". Genomics. 79 (3): 285–96. doi:10.1006/geno.2002.6718. PMID 11863358.
^ "Entrez Gene: APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C".
^ Yu Q, Chen D, König R, Mariani R, Unutmaz D, Landau NR (December 2004). "APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication". The Journal of Biological Chemistry. 279 (51): 53379–86. doi:10.1074/jbc.M408802200. PMID 15466872.
^ Jaguva Vasudevan AA, Hofmann H, Willbold D, Häussinger D, Koenig BW, Münk C (April 2017). "Enhancing the Catalytic Deamination Activity of APOBEC3C Is Insufficient to Inhibit Vif-Deficient HIV-1". Journal of Molecular Biology. 429 (8): 1171–1191. doi:10.1016/j.jmb.2017.03.015. PMID 28315663.
^ Baumert TF, Rösler C, Malim MH, von Weizsäcker F (September 2007). "Hepatitis B virus DNA is subject to extensive editing by the human deaminase APOBEC3C". Hepatology. 46 (3): 682–9. doi:10.1002/hep.21733. PMID 17625792.
^ Suspène R, Aynaud MM, Koch S, Pasdeloup D, Labetoulle M, Gaertner B, Vartanian JP, Meyerhans A, Wain-Hobson S (August 2011). "Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo". Journal of Virology. 85 (15): 7594–602. doi:10.1128/JVI.00290-11. PMC 3147940. PMID 21632763.
^ Köck J, Blum HE (May 2008). "Hypermutation of hepatitis B virus genomes by APOBEC3G, APOBEC3C and APOBEC3H". The Journal of General Virology. 89 (Pt 5): 1184–91. doi:10.1099/vir.0.83507-0. PMID 18420796.
^ Li D, Liu J, Kang F, Guan W, Gao X, Wang Y, Sun D (October 2011). "Core-APOBEC3C chimerical protein inhibits hepatitis B virus replication". Journal of Biochemistry. 150 (4): 371–4. doi:10.1093/jb/mvr086. PMID 21746770.
^ Ahasan MM, Wakae K, Wang Z, Kitamura K, Liu G, Koura M, Imayasu M, Sakamoto N, Hanaoka K, Nakamura M, Kyo S, Kondo S, Fujiwara H, Yoshizaki T, Mori S, Kukimoto I, Muramatsu M (February 2015). "APOBEC3A and 3C decrease human papillomavirus 16 pseudovirion infectivity". Biochemical and Biophysical Research Communications. 457 (3): 295–9. doi:10.1016/j.bbrc.2014.12.103. hdl:2297/44628. PMID 25576866.
^ Yu Q, König R, Pillai S, Chiles K, Kearney M, Palmer S, Richman D, Coffin JM, Landau NR (May 2004). "Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome". Nature Structural & Molecular Biology. 11 (5): 435–42. doi:10.1038/nsmb758. PMID 15098018.
^ Harris RS, Petersen-Mahrt SK, Neuberger MS (November 2002). "RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators". Molecular Cell. 10 (5): 1247–53. doi:10.1016/s1097-2765(02)00742-6. PMID 12453430.
^ Harris RS, Sheehy AM, Craig HM, Malim MH, Neuberger MS (July 2003). "DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses". Nature Immunology. 4 (7): 641–3. doi:10.1038/ni0703-641. PMID 12830140.
^ Harris RS, Bishop KN, Sheehy AM, Craig HM, Petersen-Mahrt SK, Watt IN, Neuberger MS, Malim MH (June 2003). "DNA deamination mediates innate immunity to retroviral infection". Cell. 113 (6): 803–9. doi:10.1016/s0092-8674(03)00423-9. PMID 12809610.
^ Yu Q, Chen D, König R, Mariani R, Unutmaz D, Landau NR (December 2004). "APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication". The Journal of Biological Chemistry. 279 (51): 53379–86. doi:10.1074/jbc.M408802200. PMID 15466872.
^ Ayyappan Jaguva Vasudevan, Ananda; Balakrishnan, Kannan; G. W. Gertzen, Christoph; Borvető, Fanni; Zhang, Zeli; Sangwiman, Anucha; Held, Ulrike; Küstermann, Caroline; Banerjee, Sharmistha; Schumann, Gerald G.; Häussinger, Dieter (October 2020). "Loop 1 of APOBEC3C regulates its antiviral activity against HIV-1". Journal of Molecular Biology: S0022283620305891. doi:10.1016/j.jmb.2020.10.014.
^ Kitamura S, Ode H, Nakashima M, Imahashi M, Naganawa Y, Kurosawa T, Yokomaku Y, Yamane T, Watanabe N, Suzuki A, Sugiura W, Iwatani Y (October 2012). "The APOBEC3C crystal structure and the interface for HIV-1 Vif binding". Nature Structural & Molecular Biology. 19 (10): 1005–10. doi:10.1038/nsmb.2378. PMID 23001005.
^ Zhang Z, Gu Q, Jaguva Vasudevan AA, Jeyaraj M, Schmidt S, Zielonka J, Perković M, Heckel JO, Cichutek K, Häussinger D, Smits SH, Münk C (November 2016). "Vif Proteins from Diverse Human Immunodeficiency Virus/Simian Immunodeficiency Virus Lineages Have Distinct Binding Sites in A3C". Journal of Virology. 90 (22): 10193–10208. doi:10.1128/JVI.01497-16. PMC 5105656. PMID 27581978.
^ Horn AV, Klawitter S, Held U, Berger A, Vasudevan AA, Bock A, Hofmann H, Hanschmann KM, Trösemeier JH, Flory E, Jabulowsky RA, Han JS, Löwer J, Löwer R, Münk C, Schumann GG (January 2014). "Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity". Nucleic Acids Research. 42 (1): 396–416. doi:10.1093/nar/gkt898. PMC 3874205. PMID 24101588.

추가 정보

Wedekind JE, Dance GS, Sowden MP, Smith HC (April 2003). "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business". Trends in Genetics. 19 (4): 207–16. doi:10.1016/S0168-9525(03)00054-4. PMID 12683974.
Cullen BR (February 2006). "Role and mechanism of action of the APOBEC3 family of antiretroviral resistance factors". Journal of Virology. 80 (3): 1067–76. doi:10.1128/JVI.80.3.1067-1076.2006. PMC 1346961. PMID 16414984.
Vasudevan AA, Smits SH, Höppner A, Häussinger D, Koenig BW, Münk C (November 2013). "Structural features of antiviral DNA cytidine deaminases" (PDF). Biological Chemistry. 394 (11): 1357–70. doi:10.1515/hsz-2013-0165. PMID 23787464.
Haché G, Mansky LM, Harris RS (2006). "Human APOBEC3 proteins, retrovirus restriction, and HIV drug resistance". AIDS Reviews. 8 (3): 148–57. PMID 17078485.
Madsen P, Anant S, Rasmussen HH, Gromov P, Vorum H, Dumanski JP, Tommerup N, Collins JE, Wright CL, Dunham I, MacGinnitie AJ, Davidson NO, Celis JE (August 1999). "Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1". The Journal of Investigative Dermatology. 113 (2): 162–9. doi:10.1046/j.1523-1747.1999.00682.x. PMID 10469298.
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Mariani R, Chen D, Schröfelbauer B, Navarro F, König R, Bollman B, Münk C, Nymark-McMahon H, Landau NR (July 2003). "Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif". Cell. 114 (1): 21–31. doi:10.1016/S0092-8674(03)00515-4. PMID 12859895.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Yu Q, Chen D, König R, Mariani R, Unutmaz D, Landau NR (December 2004). "APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication". The Journal of Biological Chemistry. 279 (51): 53379–86. doi:10.1074/jbc.M408802200. PMID 15466872.
Langlois MA, Beale RC, Conticello SG, Neuberger MS (2005). "Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificities". Nucleic Acids Research. 33 (6): 1913–23. doi:10.1093/nar/gki343. PMC 1074398. PMID 15809227.
Pope SN, Lee IR (February 2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". The Journal of Steroid Biochemistry and Molecular Biology. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.
Doehle BP, Schäfer A, Wiegand HL, Bogerd HP, Cullen BR (July 2005). "Differential sensitivity of murine leukemia virus to APOBEC3-mediated inhibition is governed by virion exclusion". Journal of Virology. 79 (13): 8201–7. doi:10.1128/JVI.79.13.8201-8207.2005. PMC 1143768. PMID 15956565.
Rose KM, Marin M, Kozak SL, Kabat D (July 2005). "Regulated production and anti-HIV type 1 activities of cytidine deaminases APOBEC3B, 3F, and 3G". AIDS Research and Human Retroviruses. 21 (7): 611–9. doi:10.1089/aid.2005.21.611. PMID 16060832.
Muckenfuss H, Hamdorf M, Held U, Perkovic M, Löwer J, Cichutek K, Flory E, Schumann GG, Münk C (August 2006). "APOBEC3 proteins inhibit human LINE-1 retrotransposition". The Journal of Biological Chemistry. 281 (31): 22161–72. doi:10.1074/jbc.M601716200. PMID 16735504.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Kinomoto M, Kanno T, Shimura M, Ishizaka Y, Kojima A, Kurata T, Sata T, Tokunaga K (2007). "All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition". Nucleic Acids Research. 35 (9): 2955–64. doi:10.1093/nar/gkm181. PMC 1888823. PMID 17439959.

외부 링크

UCSC Genome Browser의 Human APOBC3C 게놈 위치 및 APOBC3C 유전자 상세 페이지.
PDB for UniProt: Q9NRW3(DNA dC->dU 편집 효소 APOBEC-3C)에서 PDBe-KB에서 사용 가능한 모든 구조 정보의 개요.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000244509 - 앙상블, 2017년 5월

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11863358-3] Jarmuz A, Chester A, Bayliss J, Gisbourne J, Dunham I, Scott J, Navaratnam N (March 2002). "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22". Genomics. 79 (3): 285–96. doi:10.1006/geno.2002.6718. PMID 11863358.

[entrez-4] "Entrez Gene: APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C".

[5] Yu Q, Chen D, König R, Mariani R, Unutmaz D, Landau NR (December 2004). "APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication". The Journal of Biological Chemistry. 279 (51): 53379–86. doi:10.1074/jbc.M408802200. PMID 15466872.

[6] Jaguva Vasudevan AA, Hofmann H, Willbold D, Häussinger D, Koenig BW, Münk C (April 2017). "Enhancing the Catalytic Deamination Activity of APOBEC3C Is Insufficient to Inhibit Vif-Deficient HIV-1". Journal of Molecular Biology. 429 (8): 1171–1191. doi:10.1016/j.jmb.2017.03.015. PMID 28315663.

[7] Baumert TF, Rösler C, Malim MH, von Weizsäcker F (September 2007). "Hepatitis B virus DNA is subject to extensive editing by the human deaminase APOBEC3C". Hepatology. 46 (3): 682–9. doi:10.1002/hep.21733. PMID 17625792.

[8] Suspène R, Aynaud MM, Koch S, Pasdeloup D, Labetoulle M, Gaertner B, Vartanian JP, Meyerhans A, Wain-Hobson S (August 2011). "Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo". Journal of Virology. 85 (15): 7594–602. doi:10.1128/JVI.00290-11. PMC 3147940. PMID 21632763.

[9] Köck J, Blum HE (May 2008). "Hypermutation of hepatitis B virus genomes by APOBEC3G, APOBEC3C and APOBEC3H". The Journal of General Virology. 89 (Pt 5): 1184–91. doi:10.1099/vir.0.83507-0. PMID 18420796.

[10] Li D, Liu J, Kang F, Guan W, Gao X, Wang Y, Sun D (October 2011). "Core-APOBEC3C chimerical protein inhibits hepatitis B virus replication". Journal of Biochemistry. 150 (4): 371–4. doi:10.1093/jb/mvr086. PMID 21746770.

[11] Ahasan MM, Wakae K, Wang Z, Kitamura K, Liu G, Koura M, Imayasu M, Sakamoto N, Hanaoka K, Nakamura M, Kyo S, Kondo S, Fujiwara H, Yoshizaki T, Mori S, Kukimoto I, Muramatsu M (February 2015). "APOBEC3A and 3C decrease human papillomavirus 16 pseudovirion infectivity". Biochemical and Biophysical Research Communications. 457 (3): 295–9. doi:10.1016/j.bbrc.2014.12.103. hdl:2297/44628. PMID 25576866.

[12] Yu Q, König R, Pillai S, Chiles K, Kearney M, Palmer S, Richman D, Coffin JM, Landau NR (May 2004). "Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome". Nature Structural & Molecular Biology. 11 (5): 435–42. doi:10.1038/nsmb758. PMID 15098018.

[13] Harris RS, Petersen-Mahrt SK, Neuberger MS (November 2002). "RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators". Molecular Cell. 10 (5): 1247–53. doi:10.1016/s1097-2765(02)00742-6. PMID 12453430.

[14] Harris RS, Sheehy AM, Craig HM, Malim MH, Neuberger MS (July 2003). "DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses". Nature Immunology. 4 (7): 641–3. doi:10.1038/ni0703-641. PMID 12830140.

[15] Harris RS, Bishop KN, Sheehy AM, Craig HM, Petersen-Mahrt SK, Watt IN, Neuberger MS, Malim MH (June 2003). "DNA deamination mediates innate immunity to retroviral infection". Cell. 113 (6): 803–9. doi:10.1016/s0092-8674(03)00423-9. PMID 12809610.

[16] Yu Q, Chen D, König R, Mariani R, Unutmaz D, Landau NR (December 2004). "APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication". The Journal of Biological Chemistry. 279 (51): 53379–86. doi:10.1074/jbc.M408802200. PMID 15466872.

[17] Ayyappan Jaguva Vasudevan, Ananda; Balakrishnan, Kannan; G. W. Gertzen, Christoph; Borvető, Fanni; Zhang, Zeli; Sangwiman, Anucha; Held, Ulrike; Küstermann, Caroline; Banerjee, Sharmistha; Schumann, Gerald G.; Häussinger, Dieter (October 2020). "Loop 1 of APOBEC3C regulates its antiviral activity against HIV-1". Journal of Molecular Biology: S0022283620305891. doi:10.1016/j.jmb.2020.10.014.

[18] Kitamura S, Ode H, Nakashima M, Imahashi M, Naganawa Y, Kurosawa T, Yokomaku Y, Yamane T, Watanabe N, Suzuki A, Sugiura W, Iwatani Y (October 2012). "The APOBEC3C crystal structure and the interface for HIV-1 Vif binding". Nature Structural & Molecular Biology. 19 (10): 1005–10. doi:10.1038/nsmb.2378. PMID 23001005.

[19] Zhang Z, Gu Q, Jaguva Vasudevan AA, Jeyaraj M, Schmidt S, Zielonka J, Perković M, Heckel JO, Cichutek K, Häussinger D, Smits SH, Münk C (November 2016). "Vif Proteins from Diverse Human Immunodeficiency Virus/Simian Immunodeficiency Virus Lineages Have Distinct Binding Sites in A3C". Journal of Virology. 90 (22): 10193–10208. doi:10.1128/JVI.01497-16. PMC 5105656. PMID 27581978.

[20] Horn AV, Klawitter S, Held U, Berger A, Vasudevan AA, Bock A, Hofmann H, Hanschmann KM, Trösemeier JH, Flory E, Jabulowsky RA, Han JS, Löwer J, Löwer R, Münk C, Schumann GG (January 2014). "Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity". Nucleic Acids Research. 42 (1): 396–416. doi:10.1093/nar/gkt898. PMC 3874205. PMID 24101588.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

v t 가수분해효소: 탄소질소 비펩타이드(EC 3.5)
3.5.1: 선형 아미드 / 아미도히드로라아제	아스파라기가아제 글루타미나아제 우레아제 비오티니다아제 아미노아실라아제 ACY1 아스파토아실라아제(ACY2) ACY3 세라마이다아제 아스파틸글루코사미니다아제 지방산아미드 가수분해효소 히스톤탈아세틸화효소 시르투인
3.5.2: 고리형 아미드/ 아미도히드로라아제	바르비투라아제 베타락타마아제 디히드로오로타아제
3.5.3: 선형 아미딘/ 우레오히드로라아제	아르기나아제 아그마티나아제 단백질-아르기닌탈미나아제
3.5.4: 고리형 아미딘/ 아미노하이드롤라아제	구아닌탈아미나아제 아데노신탈아미나아제 AMP탈아미나아제 이노신1인산합성효소 DCMP탈아미나아제 GTP시클로히드로라아제I 시티딘탈아미나아제 AICDA 활성화유도시티딘탈아미나아제
3.5.5: 니트릴/ 아미노하이드롤라아제	니트릴라아제
3.5.99: 기타	리보플라비나아제 티아미나아제II

v t 효소
활동	활성 사이트 바인딩 사이트 촉매 삼합체 옥시 음이온 홀 효소 문란성 확산제한효소 코엔자임 보조인자 효소 촉매 작용
규정	알로스테릭 조절 협동성 효소억제제 효소활성화제
분류	EC 번호 효소 슈퍼 패밀리 효소족 효소 목록
동력학	효소역학 Eadie-Hofstee 다이어그램 하네스-울프 그림 Lineweaver-Burk 그림 미카엘리스 멘텐 동역학
종류들	EC1 산화환원효소(목록) EC2 전송효소(리스트) EC3 가수분해효소 (리스트) EC4 리아제 (리스트) EC5 이성질화효소 (리스트) EC6 연결효소(리스트) EC7 트랜스로케이스 (리스트)

Search

아포벡3C

네임스페이스

더

목차

기능.

구조.

레퍼런스

추가 정보

외부 링크