아스파릴글루코사미다아제
Aspartylglucosaminidase| AGA | |||||||||||||||||||||||||
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| 식별자 | |||||||||||||||||||||||||
| 별칭 | AGA, Aga, AW060726, AGU, ASRG, GA, aspartyllucosaminidase | ||||||||||||||||||||||||
| 외부 ID | OMIM: 613228 MGI: 104873 HomoloGene: 13 GeneCard: AGA | ||||||||||||||||||||||||
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| 직교체 | |||||||||||||||||||||||||
| 종 | 인간 | 마우스 | |||||||||||||||||||||||
| 엔트레스 | |||||||||||||||||||||||||
| 앙상블 | |||||||||||||||||||||||||
| 유니프로트 | |||||||||||||||||||||||||
| RefSeq(mRNA) | |||||||||||||||||||||||||
| RefSeq(단백질) | |||||||||||||||||||||||||
| 위치(UCSC) | Chr 4: 177.43 – 177.44Mb | Chr 8: 53.51 – 53.52Mb | |||||||||||||||||||||||
| PubMed 검색 | [3] | [4] | |||||||||||||||||||||||
| 위키다타 | |||||||||||||||||||||||||
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N(4)-(베타-N-아세틸글루코사미닐)-L-아스파라기나아제는 인간에서 AGA 유전자에 의해 암호화된 효소다.[5]null
아스파당llucosaminidase는 당단백질의 N연계 올리고당류의 카타볼리즘에 관여하는 아미도하이드롤라제 효소다.그것은 당단백질의 리소솜 분해의 마지막 단계 중 하나로 N-아세틸글루코사민에서 아스파라긴을 분리한다.Lysosomal 저장 질환인 aspartylglycosaminuria는 AGA 효소의 결핍에 의해 발생한다.[5]null
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG000038002 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000031521 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: AGA aspartylglucosaminidase".
외부 링크
- UCSC 게놈 브라우저의 인간 AGA 게놈 위치 및 AGA 유전자 세부 정보 페이지.
추가 읽기
- Ikonen E, Peltonen L (1993). "Mutations causing aspartylglucosaminuria (AGU): a lysosomal accumulation disease". Hum. Mutat. 1 (5): 361–5. doi:10.1002/humu.1380010503. PMID 1301945. S2CID 24301019.
- Mononen I, Fisher KJ, Kaartinen V, Aronson NN (1993). "Aspartylglycosaminuria: protein chemistry and molecular biology of the most common lysosomal storage disorder of glycoprotein degradation". FASEB J. 7 (13): 1247–56. doi:10.1096/fasebj.7.13.8405810. PMID 8405810. S2CID 21771613.
- Enomaa N, Heiskanen T, Halila R, et al. (1992). "Human aspartylglucosaminidase. A biochemical and immunocytochemical characterization of the enzyme in normal and aspartylglucosaminuria fibroblasts". Biochem. J. 286 ( Pt 2) (Pt 2): 613–8. doi:10.1042/bj2860613. PMC 1132942. PMID 1530592.
- Ikonen E, Baumann M, Grön K, et al. (1991). "Aspartylglucosaminuria: cDNA encoding human aspartylglucosaminidase and the missense mutation causing the disease". EMBO J. 10 (1): 51–8. doi:10.1002/j.1460-2075.1991.tb07920.x. PMC 452610. PMID 1703489.
- Morris C, Heisterkamp N, Groffen J, et al. (1992). "Chromosomal localization of the human glycoasparaginase gene to 4q32-q33". Hum. Genet. 88 (3): 295–7. doi:10.1007/BF00197262. PMID 1733831. S2CID 8805853.
- Ikonen E, Enomaa N, Ulmanen I, Peltonen L (1992). "In vitro mutagenesis helps to unravel the biological consequences of aspartylglucosaminuria mutation". Genomics. 11 (1): 206–11. doi:10.1016/0888-7543(91)90120-4. PMID 1765378.
- Park H, Fisher KJ, Aronson NN (1991). "Genomic structure of human lysosomal glycosylasparaginase". FEBS Lett. 288 (1–2): 168–72. doi:10.1016/0014-5793(91)81027-6. PMID 1840528. S2CID 26680929.
- Mononen T, Mononen I, Matilainen R, Airaksinen E (1991). "High prevalence of aspartylglycosaminuria among school-age children in eastern Finland". Hum. Genet. 87 (3): 266–8. doi:10.1007/BF00200902. PMID 1864600. S2CID 8240322.
- Fisher KJ, Aronson NN (1991). "Characterization of the mutation responsible for aspartylglucosaminuria in three Finnish patients. Amino acid substitution Cys163----Ser abolishes the activity of lysosomal glycosylasparaginase and its conversion into subunits". J. Biol. Chem. 266 (18): 12105–13. doi:10.1016/S0021-9258(18)99071-X. PMID 1904874.
- Mononen I, Heisterkamp N, Kaartinen V, et al. (1991). "Aspartylglycosaminuria in the Finnish population: identification of two point mutations in the heavy chain of glycoasparaginase". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2941–5. Bibcode:1991PNAS...88.2941M. doi:10.1073/pnas.88.7.2941. PMC 51356. PMID 2011603.
- Halila R, Baumann M, Ikonen E, et al. (1991). "Human leucocyte aspartylglucosaminidase. Evidence for two different subunits in a more complex native structure". Biochem. J. 276 ( Pt 1) (Pt 1): 251–6. doi:10.1042/bj2760251. PMC 1151172. PMID 2039475.
- Fisher KJ, Tollersrud OK, Aronson NN (1991). "Cloning and sequence analysis of a cDNA for human glycosylasparaginase. A single gene encodes the subunits of this lysosomal amidase". FEBS Lett. 276 (1–2): 232. doi:10.1016/0014-5793(90)80551-S. PMID 2265705. S2CID 221417722.
- Fisher KJ, Tollersrud OK, Aronson NN (1990). "Cloning and sequence analysis of a cDNA for human glycosylasparaginase. A single gene encodes the subunits of this lysosomal amidase". FEBS Lett. 269 (2): 440–4. doi:10.1016/0014-5793(90)81211-6. PMID 2401370. S2CID 8210082.
- Tollersrud OK, Aronson NN (1989). "Purification and characterization of rat liver glycosylasparaginase". Biochem. J. 260 (1): 101–8. doi:10.1042/bj2600101. PMC 1138631. PMID 2775174.
- Hreidarsson S, Thomas GH, Valle DL, et al. (1983). "Aspartylglucosaminuria in the United States". Clin. Genet. 23 (6): 427–35. doi:10.1111/j.1399-0004.1983.tb01977.x. PMID 6883788. S2CID 46703938.
- Enomaa NE, Lukinmaa PL, Ikonen EM, et al. (1993). "Expression of aspartylglucosaminidase in human tissues from normal individuals and aspartylglucosaminuria patients". J. Histochem. Cytochem. 41 (7): 981–9. doi:10.1177/41.7.7685790. PMID 7685790.
- McCormack AL, Mononen I, Kaartinen V, Yates JR (1995). "Localization of the disulfide bond involved in post-translational processing of glycosylasparaginase and disrupted by a mutation in the Finnish-type aspartylglycosaminuria". J. Biol. Chem. 270 (7): 3212–5. doi:10.1074/jbc.270.7.3212. PMID 7852406.
- Tollersrud OK, Heiskanen T, Peltonen L (1994). "Human leucocyte glycosylasparaginase is an alpha/beta-heterodimer of 19 kDa alpha-subunit and 17 and 18 kDa beta-subunit". Biochem. J. 300 ( Pt 2) (Pt 2): 541–4. doi:10.1042/bj3000541. PMC 1138195. PMID 8002961.
PDB 갤러리 | |
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외부 링크
- 미국 국립 의학 도서관의 Aspartyllucosylaminase(ASpartyllucosylamase, 미국 국립 의학 과목 제목)
