PSMF1
PSMF1
프로테아솜 억제제 PI31 서브유닛은 인간에서 PSMF1 유전자에 의해 암호화된 단백질이다.[5][6]
함수
26S 프로테아솜은 20S 코어 및 19S 레귤레이터 2개 콤플렉스로 구성된 고순도 구조의 다분석성 단백질효소 복합체다.20S 코어는 28개의 비식별 서브유닛 중 4개의 링으로 구성되며, 2개의 링은 7개의 알파 서브유닛으로 구성되고 2개의 링은 7개의 베타 서브유닛으로 구성된다.19S 조절기는 6개의 ATPase 서브유닛과 2개의 비 ATPase 서브유닛을 포함하는 베이스와 최대 10개의 비 ATPase 서브유닛을 포함하는 뚜껑으로 구성된다.프로테아솜은 높은 농도의 진핵 세포와 클레이브 펩타이드가 비 리소솜 경로에서 ATP/ubiquitin 의존적 공정으로 분산된다.변형된 프로테아솜의 필수적인 기능인 면역단백제는 클래스 I MHC 펩타이드의 처리다.이 유전자는 11S와 19S 규제자에 의해 프로테아솜의 활성화를 억제하는 단백질을 암호화하고 있다.이 유전자에 대한 대체 성적표 변형이 확인되었다.[6]
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000125818 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000032869 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Tanahashi N, Kawahara H, Murakami Y, Tanaka K (Apr 1999). "The proteasome-dependent proteolytic system". Molecular Biology Reports. 26 (1–2): 3–9. doi:10.1023/A:1006909522731. PMID 10363639. S2CID 38305744.
- ^ a b "Entrez Gene: PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)".
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