아폴리포단백질A-II
Apolipoprotein A-II
| ApoA-II | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 아폴리포단백질 a-ii와 지질대리복합체의 구조는 아폴리포단백질-지질 상호작용에 대한 통찰력을 제공한다 | |||||||||
| 식별자 | |||||||||
| 기호. | ApoA-II | ||||||||
| 팜 | PF04711 | ||||||||
| 인터프로 | IPR006801 | ||||||||
| SCOP2 | 1l6k/SCOPe/SUPFAM | ||||||||
| |||||||||
아폴리포단백질 A-II는 사람에게서 APOA2 [5]유전자에 의해 암호화되는 단백질이다.
기능.
APOA2는 고밀도 리포단백질 입자 중 두 번째로 풍부한 단백질인 아폴리포단백질 A-II, (ApoA-II)를 코드한다.그 단백질은 아폴리포단백질 D를 가진 단량체, 호모디머 또는 헤테로디머로 혈장에서 발견된다.이 유전자의 결함은 아폴리포단백질 A-II 결핍 또는 고콜레스테롤혈증을 [6]초래할 수 있다.
상호 작용
ApoA-II는 인지질 전달 [7]단백질과 상호작용하는 것으로 나타났다.
인터랙티브 패스 맵
아래의 유전자, 단백질 및 대사물을 클릭하여 각각의 기사와 연결하세요. [§ 1]
Statin 경로 편집
- ^ 대화형 경로 맵은 WikiPathways에서 편집할 수 있습니다."Statin_Pathway_WP430".
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000158874 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000005681 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Tsao YK, Wei CF, Robberson DL, Gotto AM, Chan L (Dec 1985). "Isolation and characterization of the human apolipoprotein A-II gene. Electron microscopic analysis of RNA:DNA hybrids, nucleotide sequence, identification of a polymorphic MspI site, and general structural organization of apolipoprotein genes". The Journal of Biological Chemistry. 260 (28): 15222–31. doi:10.1016/S0021-9258(18)95725-X. PMID 2415515.
- ^ "Entrez Gene: APOA2 apolipoprotein A-II".
- ^ Pussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, Ehnholm C (Jan 1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". Journal of Lipid Research. 39 (1): 152–61. doi:10.1016/S0022-2275(20)34211-5. PMID 9469594.
외부 링크
- UCSC Genome Browser의 인간 APOA2 게놈 위치 및 APOA2 유전자 세부 정보 페이지.
추가 정보
- Blanco-Vaca F, Escolà-Gil JC, Martín-Campos JM, Julve J (Nov 2001). "Role of apoA-II in lipid metabolism and atherosclerosis: advances in the study of an enigmatic protein". Journal of Lipid Research. 42 (11): 1727–39. doi:10.1016/S0022-2275(20)31499-1. PMID 11714842.
- Kalopissis AD, Pastier D, Chambaz J (Apr 2003). "Apolipoprotein A-II: beyond genetic associations with lipid disorders and insulin resistance". Current Opinion in Lipidology. 14 (2): 165–72. doi:10.1097/00041433-200304000-00008. PMID 12642785. S2CID 7365994.
- Vollmer E, Brust J, Roessner A, Bosse A, Burwikel F, Kaesberg B, Harrach B, Robenek H, Böcker W (1991). "Distribution patterns of apolipoproteins A1, A2, and B in the wall of atherosclerotic vessels". Virchows Archiv A. 419 (2): 79–88. doi:10.1007/BF01600220. PMID 1908160. S2CID 31793659.
- Deeb SS, Takata K, Peng RL, Kajiyama G, Albers JJ (Apr 1990). "A splice-junction mutation responsible for familial apolipoprotein A-II deficiency". American Journal of Human Genetics. 46 (4): 822–7. PMC 1683675. PMID 2107739.
- Gordon JI, Sims HF, Edelstein C, Scanu AM, Strauss AW (Nov 1985). "Extracellular processing of proapolipoprotein A-II in Hep G2 cell cultures is mediated by a 54-kDa protease immunologically related to cathepsin B". The Journal of Biological Chemistry. 260 (27): 14824–31. doi:10.1016/S0021-9258(17)38646-5. PMID 2414299.
- Lackner KJ, Law SW, Brewer HB (Jun 1985). "The human apolipoprotein A-II gene: complete nucleic acid sequence and genomic organization". Nucleic Acids Research. 13 (12): 4597–608. doi:10.1093/nar/13.12.4597. PMC 321808. PMID 2989800.
- Knott TJ, Wallis SC, Robertson ME, Priestley LM, Urdea M, Rall LB, Scott J (Sep 1985). "The human apolipoprotein AII gene: structural organization and sites of expression". Nucleic Acids Research. 13 (17): 6387–98. doi:10.1093/nar/13.17.6387. PMC 321960. PMID 2995928.
- Chan L, Moore MN, Tsao YK (1986). "Molecular cloning and sequence analysis of human apolipoprotein A-II cDNA". Methods in Enzymology. 128: 745–52. doi:10.1016/0076-6879(86)28103-3. ISBN 978-0-12-182028-2. PMID 3088392.
- Middleton-Price HR, van den Berghe JA, Scott J, Knott TJ, Malcolm S (Jul 1988). "Regional chromosomal localisation of APOA2 to 1q21-1q23". Human Genetics. 79 (3): 283–5. doi:10.1007/BF00366253. PMID 3136074. S2CID 35574652.
- Shelley CS, Sharpe CR, Baralle FE, Shoulders CC (Nov 1985). "Comparison of the human apolipoprotein genes. Apo AII presents a unique functional intron-exon junction". Journal of Molecular Biology. 186 (1): 43–51. doi:10.1016/0022-2836(85)90255-4. PMID 3935800.
- Brewer HB, Lux SE, Ronan R, John KM (May 1972). "Amino acid sequence of human apoLp-Gln-II (apoA-II), an apolipoprotein isolated from the high-density lipoprotein complex". Proceedings of the National Academy of Sciences of the United States of America. 69 (5): 1304–8. Bibcode:1972PNAS...69.1304B. doi:10.1073/pnas.69.5.1304. PMC 426687. PMID 4338591.
- Lux SE, John KM, Ronan R, Brewer HB (Dec 1972). "Isolation and characterization of the tryptic and cyanogen bromide peptides of apoLp-Gln-II (apoA-II), plasma high density apolipoprotein". The Journal of Biological Chemistry. 247 (23): 7519–27. doi:10.1016/S0021-9258(19)44556-0. PMID 4344225.
- Moore MN, Kao FT, Tsao YK, Chan L (Aug 1984). "Human apolipoprotein A-II: nucleotide sequence of a cloned cDNA, and localization of its structural gene on human chromosome 1". Biochemical and Biophysical Research Communications. 123 (1): 1–7. doi:10.1016/0006-291X(84)90371-1. PMID 6089788.
- Lackner KJ, Law SW, Brewer HB (Sep 1984). "Human apolipoprotein A-II: complete nucleic acid sequence of preproapo A-II". FEBS Letters. 175 (1): 159–64. doi:10.1016/0014-5793(84)80590-6. PMID 6090207. S2CID 9320651.
- Gordon JI, Budelier KA, Sims HF, Edelstein C, Scanu AM, Strauss AW (Nov 1983). "Biosynthesis of human preproapolipoprotein A-II". The Journal of Biological Chemistry. 258 (22): 14054–9. doi:10.1016/S0021-9258(17)44023-3. PMID 6315718.
- Sharpe CR, Sidoli A, Shelley CS, Lucero MA, Shoulders CC, Baralle FE (May 1984). "Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance". Nucleic Acids Research. 12 (9): 3917–32. doi:10.1093/nar/12.9.3917. PMC 318799. PMID 6328445.
- Stoffel W, Krüger E, Deutzmann R (Mar 1983). "Cell-free translation of human liver apolipoprotein AI and AII mRNA. Processing of primary translation products". Hoppe-Seyler's Zeitschrift für Physiologische Chemie. 364 (3): 227–37. doi:10.1515/bchm2.1983.364.1.227. PMID 6407957.
- Knott TJ, Priestley LM, Urdea M, Scott J (May 1984). "Isolation and characterisation of a cDNA encoding the precursor for human apolipoprotein AII". Biochemical and Biophysical Research Communications. 120 (3): 734–40. doi:10.1016/S0006-291X(84)80168-0. PMID 6428397.
- Lackner KJ, Law SW, Brewer HB, Sakaguchi AY, Naylor SL (Aug 1984). "The human apolipoprotein A-II gene is located on chromosome 1". Biochemical and Biophysical Research Communications. 122 (3): 877–83. doi:10.1016/0006-291X(84)91172-0. PMID 6433912.
