성장인자 수용체 결합 단백질 7 은 GRB7 유전자 로 인코딩되는 단백질 이다.[5] [6]
함수 이 유전자의 산물은 다수의 수용체 타이로신 키나제 및 신호 분자와 상호작용하는 것으로 알려진 작은 적응 단백질군 에 속한다. 이 유전자는 표피 성장인자 수용체 (EGFR) 및 에프린 수용체 와 상호작용하는 성장인자 수용체 결합 단백질을 인코딩한다. 단백질은 초점접착키나아제 (FAK)와 결합하여 통합신호 경로와 세포이동에 역할을 한다. 대체 스플라이싱 은 다른 ISO 형식 을 인코딩하는 다중 대본 변형을 초래하지만, 두 변종 중 오직 두 변종만이 지금까지 결정되었다.[5]
임상적 유의성 GRB7은 수용체 타이로신 키네아제 에 결합하는 SH2 도메인 어댑터 단백질 로, 세포 내 Ras proto-oncgene 에 직접 링크를 제공한다. 인간 GRB7은 17번 염색체 의 긴 팔, ERBB2(가명 HER2/neu ) 양성자-종양자 옆에 위치한다.
이 두 유전자는 유방암 에서 일반적으로 공동증식(과다복사)된다.이주에[citation needed 관여한다고 생각되는 GRB7은 고환균세포종양 , 식도암 , 위암 등 에서 과다하게 발현되는 것으로 잘 알려져 있다.
상호작용 GRB7은 다음과 상호 작용하는 것으로 나타났다.
모형 유기체 모델 유기체 는 GRB7 기능의 연구에 사용되어 왔다.Wellcome Trust Sanger Institute 에서 Grb7 이라는tm1b(EUCOMM)Wtsi 조건부 녹아웃 마우스 라인이 생성되었다.[12] 수컷과 암컷은 삭제 효과를 판단하기 위해 표준화된 표현식 화면 을[13] [14] [15] [16] [17] 수행된 추가 화면: - 심층 면역 표현식[18]
Grb7 녹아웃 마우스 표현형 특성 표현형 사용 가능한 모든 데이터:[13] [18] 말초혈구 백혈구 6주 정상 혈액학 정상 P14의 동질성 생존성 정상 동족 생식 정상 체중 정상 신경학적 평가 정상 그립 강도 정상 이형학 정상 간접열량측정법 정상 포도당 공차 검정 정상 청각 뇌계 반응 정상 덱사 정상 눈 형태학 정상 임상화학 정상 혈액학 정상 말초혈구 백혈구 16주 정상 심장 무게 정상 살모넬라균 정상 세포독성 T세포 기능 정상 비장면역결찰 정상 중신 림프절 면역항진 정상 골수 면역항진법 정상 표피 면역 구성 정상 트리추리스 챌린지 정상
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외부 링크
PDB 갤러리
1mw4 : 10개의 아미노산 펩타이드 pY1139로 복합된 인간 Grb7-SH2 영역의 솔루션 구조
1wgr : 인간 Grb7 단백질의 RA영역의 솔루션 구조
