갠치

갠치
식별자
별칭	GANC, 글루코시다아제 알파, 중성 C
외부 ID	OMIM: 104180 MGI: 1923301 호몰로진: 25627 GeneCard: GANC
유전자 위치(인간)
쳇.	15번 염색체(인간)
끝	42,196,935 bp
유전자 위치(마우스)
쳇.	염색체 2 (쥐)
끝	120,292,181 bp
RNA 표현 패턴
	표현된 상단
	수근신경; ; 말뭉치 담낭; ; 폐를 끼치다; ; 오른쪽 폐; ; 결장의; ; 좌측 폐 상부엽; ; 아킬레스건; ; 콩팥을;
	추가 참조 표현식 데이터
	n/a
직교체
	2595
	76051
	ENSG00000214013
	ENSMUSG00000062646
	Q8TET4
	Q8BVW0
	NM_198141; NM_001301409; NM_001301410
	NM_172672
	NP_001288338; NP_001288339; NP_937784
	NP_766260
	위키다타
인간 보기/편집	마우스 보기/편집

중성 알파-글루코시다아제 C는 인간에서 GANC 유전자에 의해 암호화된 효소다.^[5]^[6]^[7]

함수

글리코사이드 하이드롤라아제 효소는 둘 이상의 탄수화물 또는 탄수화물과 비탄수화물 간의 글리코시드 결합을 가수분해한다.이 유전자는 글리코실 하이드롤라아제 31의 구성원을 인코딩한다.이 효소는 단자를 가수분해하여 1,4연계 알파-D-글루코스 잔류물을 비감소하고 알파-D-글루코스를 방출한다.이것은 글리코겐 신진대사의 핵심 효소로 그 유전자는 당뇨병에 대한 감수성과 관련이 있는 염색체 부위(15q15)에 국소화된다.^[7]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000214013 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000062646 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Martiniuk F, Hirschhorn R, Smith M (Oct 1980). "Assignment of the gene for human neutral alpha-glucosidase C to chromosome 15". Cytogenetics and Cell Genetics. 27 (2–3): 168–75. doi:10.1159/000131478. PMID 6995030.
^ Hirschhorn R, Huie ML, Kasper JS (Oct 2002). "Computer assisted cloning of human neutral alpha-glucosidase C (GANC): a new paralog in the glycosyl hydrolase gene family 31". Proceedings of the National Academy of Sciences of the United States of America. 99 (21): 13642–6. Bibcode:2002PNAS...9913642H. doi:10.1073/pnas.202383599. PMC 129728. PMID 12370436.
^ ^a ^b "Entrez Gene: GANC glucosidase, alpha; neutral C".

추가 읽기

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Kamimura H, Ogata H, Takahara H (1992). "Alpha-glucoside formation of xenobiotics by rat liver alpha-glucosidases". Drug Metabolism and Disposition. 20 (2): 309–15. PMID 1352226.
Fenouillet E, Gluckman JC (Aug 1991). "Effect of a glucosidase inhibitor on the bioactivity and immunoreactivity of human immunodeficiency virus type 1 envelope glycoprotein". The Journal of General Virology. 72 (8): 1919–26. doi:10.1099/0022-1317-72-8-1919. PMID 1678778.
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Dedera DA, Gu RL, Ratner L (Mar 1992). "Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function". Virology. 187 (1): 377–82. doi:10.1016/0042-6822(92)90331-I. PMID 1736542.
Murphy CI, Lennick M, Lehar SM, Beltz GA, Young E (Oct 1990). "Temporal expression of HIV-1 envelope proteins in baculovirus-infected insect cells: implications for glycosylation and CD4 binding". Genetic Analysis, Techniques and Applications. 7 (6): 160–71. doi:10.1016/0735-0651(90)90030-J. PMID 2076345.
Kalyanaraman VS, Rodriguez V, Veronese F, Rahman R, Lusso P, DeVico AL, Copeland T, Oroszlan S, Gallo RC, Sarngadharan MG (Mar 1990). "Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1". AIDS Research and Human Retroviruses. 6 (3): 371–80. doi:10.1089/aid.1990.6.371. PMID 2187500.
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Leonard CK, Spellman MW, Riddle L, Harris RJ, Thomas JN, Gregory TJ (Jun 1990). "Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells". The Journal of Biological Chemistry. 265 (18): 10373–82. doi:10.1016/S0021-9258(18)86956-3. PMID 2355006.
Pal R, Hoke GM, Sarngadharan MG (May 1989). "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1". Proceedings of the National Academy of Sciences of the United States of America. 86 (9): 3384–8. Bibcode:1989PNAS...86.3384P. doi:10.1073/pnas.86.9.3384. PMC 287137. PMID 2541446.
Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (Jun 1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport". Journal of Virology. 63 (6): 2452–6. doi:10.1128/jvi.63.6.2452-2456.1989. PMC 250699. PMID 2542563.
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Usuki F, Ishiura S, Nonaka I, Sugita H (Apr 1988). "alpha-Glucosidase isoenzymes in normal and acid maltase-deficient human skeletal muscles". Muscle & Nerve. 11 (4): 365–71. doi:10.1002/mus.880110413. PMID 3135493. S2CID 43090032.
Montefiori DC, Robinson WE, Mitchell WM (Dec 1988). "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1". Proceedings of the National Academy of Sciences of the United States of America. 85 (23): 9248–52. Bibcode:1988PNAS...85.9248M. doi:10.1073/pnas.85.23.9248. PMC 282716. PMID 3264072.

이 단백질 관련 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000214013 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000062646 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid6995030-5] Martiniuk F, Hirschhorn R, Smith M (Oct 1980). "Assignment of the gene for human neutral alpha-glucosidase C to chromosome 15". Cytogenetics and Cell Genetics. 27 (2–3): 168–75. doi:10.1159/000131478. PMID 6995030.

[pmid12370436-6] Hirschhorn R, Huie ML, Kasper JS (Oct 2002). "Computer assisted cloning of human neutral alpha-glucosidase C (GANC): a new paralog in the glycosyl hydrolase gene family 31". Proceedings of the National Academy of Sciences of the United States of America. 99 (21): 13642–6. Bibcode:2002PNAS...9913642H. doi:10.1073/pnas.202383599. PMC 129728. PMID 12370436.

[entrez-7] "Entrez Gene: GANC glucosidase, alpha; neutral C".

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