프로스타신은 인간의 PRSS8 [5] [6] [7] 단백질 이다.
이 유전자는 세린 단백질 분해 효소의 트립신 계열의 구성원 인 트립시노겐을 암호화합니다. 이 효소는 전립선 상피에서 많이 발현되며 정액에서 발견되는 여러 단백질 분해 효소 중 하나이다.프로프로틴은 이황화물 결합에 의해 결합되는 가벼운 사슬과 무거운 사슬을 생성하기 위해 분해됩니다. 리신 또는 아르기닌 의 카르복실기와 관련된 펩타이드 결합에서 활성화된다.
단백질은 상피 나트륨 채널[8] [9]
높은 프로스타신 혈장 수치는 당뇨병과 [10] [unreliable medical source 암으로 인한 사망, 특히 고혈당 을 가진 사람들에게 더 높은 위험과 관련이 있을 수 있습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000052344 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000030800 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Yu JX, Chao L, Ward DC, Chao J (Mar 1996). "Structure and chromosomal localization of the human prostasin (PRSS8) gene". Genomics . 32 (3): 334–40. doi :10.1006/geno.1996.0127 . PMID 8838796 . ^ Yu JX, Chao L, Chao J (Jun 1995). "Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA" . The Journal of Biological Chemistry . 270 (22): 13483–9. doi :10.1074/jbc.270.22.13483 PMID 7768952 . ^ "Entrez Gene: PRSS8 protease, serine, 8" .^ Koda A, Wakida N, Toriyama K, Yamamoto K, Iijima H, Tomita K, Kitamura K (Apr 2009). "Urinary prostasin in humans: relationships among prostasin, aldosterone and epithelial sodium channel activity" . Hypertension Research . 32 (4): 276–81. doi :10.1038/hr.2009.6 PMID 19262497 . ^ Zhu H, Guo D, Li K, Yan W, Tan Y, Wang X, Treiber FA, Chao J, Snieder H, Dong Y (Sep 2008). "Prostasin: a possible candidate gene for human hypertension" . American Journal of Hypertension . 21 (9): 1028–33. doi :10.1038/ajh.2008.224 . PMC 3812941 PMID 18583984 . ^ Bao X, Xu B, Muhammad IF, Nilsson PM, Nilsson J, Engström G (August 2022). "Plasma prostasin: a novel risk marker for incidence of diabetes and cancer mortality". Diabetologia . doi :10.1007/s00125-022-05771-w . PMID 35922613 . 추가 정보 Yu JX, Chao L, Chao J (Jul 1994). "Prostasin is a novel human serine proteinase from seminal fluid. Purification, tissue distribution, and localization in prostate gland" . The Journal of Biological Chemistry . 269 (29): 18843–8. doi :10.1016/S0021-9258(17)32244-5 PMID 8034638 . Nelson PS, Gan L, Ferguson C, Moss P, Gelinas R, Hood L, Wang K (Mar 1999). "Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression" . Proceedings of the National Academy of Sciences of the United States of America . 96 (6): 3114–9. Bibcode :1999PNAS...96.3114N . doi :10.1073/pnas.96.6.3114 PMC 15904 PMID 10077646 . Chen LM, Skinner ML, Kauffman SW, Chao J, Chao L, Thaler CD, Chai KX (Jun 2001). "Prostasin is a glycosylphosphatidylinositol-anchored active serine protease" . The Journal of Biological Chemistry . 276 (24): 21434–42. doi :10.1074/jbc.M011423200 PMID 11274175 . Donaldson SH, Hirsh A, Li DC, Holloway G, Chao J, Boucher RC, Gabriel SE (Mar 2002). "Regulation of the epithelial sodium channel by serine proteases in human airways" . The Journal of Biological Chemistry . 277 (10): 8338–45. doi :10.1074/jbc.M105044200 PMID 11756432 . Wang C, Chao J, Chao L (Apr 2003). "Adenovirus-mediated human prostasin gene delivery is linked to increased aldosterone production and hypertension in rats". American Journal of Physiology. Regulatory, Integrative and Comparative Physiology . 284 (4): R1031-6. doi :10.1152/ajpregu.00660.2002 . PMID 12626364 . Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway" . Genome Research . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 PMID 15231748 . Tong Z, Illek B, Bhagwandin VJ, Verghese GM, Caughey GH (Nov 2004). "Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line". American Journal of Physiology. Lung Cellular and Molecular Physiology . 287 (5): L928-35. doi :10.1152/ajplung.00160.2004 . PMID 15246975 . Shipway A, Danahay H, Williams JA, Tully DC, Backes BJ, Harris JL (Nov 2004). "Biochemical characterization of prostasin, a channel activating protease". Biochemical and Biophysical Research Communications . 324 (2): 953–63. doi :10.1016/j.bbrc.2004.09.123 . PMID 15474520 . Leyvraz C, Charles RP, Rubera I, Guitard M, Rotman S, Breiden B, Sandhoff K, Hummler E (Aug 2005). "The epidermal barrier function is dependent on the serine protease CAP1/Prss8" . The Journal of Cell Biology . 170 (3): 487–96. doi :10.1083/jcb.200501038 . PMC 2171460 PMID 16061697 . Fan B, Wu TD, Li W, Kirchhofer D (Oct 2005). "Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin" . The Journal of Biological Chemistry . 280 (41): 34513–20. doi :10.1074/jbc.M502119200 PMID 16103126 . Chen M, Chen LM, Chai KX (Jun 2006). "Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG". The Prostate . 66 (9): 911–20. doi :10.1002/pros.20325 . PMID 16541421 . S2CID 23036264 . Rohan S, Tu JJ, Kao J, Mukherjee P, Campagne F, Zhou XK, Hyjek E, Alonso MA, Chen YT (Dec 2006). "Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes" . Clinical Cancer Research . 12 (23): 6937–45. doi :10.1158/1078-0432.CCR-06-1268 PMID 17145811 . Chen M, Fu YY, Lin CY, Chen LM, Chai KX (Jul 2007). "Prostasin induces protease-dependent and independent molecular changes in the human prostate carcinoma cell line PC-3" . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research . 1773 (7): 1133–40. doi :10.1016/j.bbamcr.2007.04.013 . PMC 1950849 PMID 17532063 . Chen LM, Hatfield ML, Fu YY, Chai KX. 프로스타신은 전립선 상피세포에서 단백질분해효소 활성화 수용체-2 신호를 변조함으로써 iNOS 및 사이클린 D1 발현을 조절한다. 전립선 2009년 12월 1일;69(16):1790-801.doi:10.1002/pros.21030. PMID : 19670249
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