히스톤 디아세틸라제 10 은 인간에서 HDAC10 유전자 에 의해 암호화된 효소 다.[5] [6] [7]
히스톤 코어 입자의 아세틸화는 염색체 구조와 유전자 발현을 조절한다. HDAC10과 같은 히스톤 아세틸트랜스퍼레이즈와 히스톤 디아세틸라제의 상반된 효소 활동은 히스톤 꼬리의 아세틸화 상태를 결정한다(Kao 등, 2002). [OMIM에 의해 제공][7]
상호작용 HDAC10은 Histone deacetylase 2 [8] Nuclear repressor 2 와 상호작용 하는 것으로 나타났다.[8]
참고 항목 참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000100429 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000062906 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Kao HY, Lee CH, Komarov A, Han CC, Evans RM (Jan 2002). "Isolation and characterization of mammalian HDAC10, a novel histone deacetylase" . J Biol Chem . 277 (1): 187–93. doi :10.1074/jbc.M108931200 PMID 11677242 . ^ Guardiola AR, Yao TP (Jan 2002). "Molecular cloning and characterization of a novel histone deacetylase HDAC10" . J Biol Chem . 277 (5): 3350–6. doi :10.1074/jbc.M109861200 PMID 11726666 . ^ a b "Entrez Gene: HDAC10 histone deacetylase 10" .^ a b Fischer, Denise D; Cai Richard; Bhatia Umesh; Asselbergs Fred A M; Song Chuanzheng; Terry Robert; Trogani Nancy; Widmer Roland; Atadja Peter; Cohen Dalia (Feb 2002). "Isolation and characterization of a novel class II histone deacetylase, HDAC10" . J. Biol. Chem . United States. 277 (8): 6656–66. doi :10.1074/jbc.M108055200 ISSN 0021-9258 . PMID 11739383 . 추가 읽기 Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22" . Nature . 402 (6761): 489–95. Bibcode :1999Natur.402..489D . doi :10.1038/990031 PMID 10591208 . Fischer DD, Cai R, Bhatia U, et al. (2002). "Isolation and characterization of a novel class II histone deacetylase, HDAC10" . J. Biol. Chem . 277 (8): 6656–66. doi :10.1074/jbc.M108055200 PMID 11739383 . Tong JJ, Liu J, Bertos NR, Yang XJ (2002). "Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain" . Nucleic Acids Res . 30 (5): 1114–23. doi :10.1093/nar/30.5.1114 . PMC 101247 PMID 11861901 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains" . J. Biol. Chem . 278 (52): 52914–8. doi :10.1074/jbc.C300407200 PMID 14578343 . Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance" . Genome Biol . 5 (2): R8. doi :10.1186/gb-2004-5-2-r8 . PMC 395752 PMID 14759258 . Osada H, Tatematsu Y, Saito H, et al. (2004). "Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients". Int. J. Cancer . 112 (1): 26–32. doi :10.1002/ijc.20395 . PMID 15305372 . S2CID 23452893 . Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome" . Genome Biol . 5 (10): R84. doi :10.1186/gb-2004-5-10-r84 . PMC 545604 PMID 15461802 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 .
외부 링크 이 기사는 공공영역 에 있는 미국 국립 의학 도서관 의 텍스트를 통합하고 있다.
