세포골격관련단백질5 는 사람에게서 CKAP5유전자 에 [5] [6] [7] 미소관관련단백질 이다.XMAP215 는[8] Xenopus ch-Tog 로도 알려져 있다.
방추형성에 있어 적어도 두 가지 뚜렷한 역할을 한다. 즉, 키네토코어 미세관을 MCAK(KIF2C )에 의한 탈중합으로부터 보호하고, ch-Tog는 MCAK [9] 중심체 미세관 조립에서 필수적인 역할을 한다.
상호 작용 CKAP5는 TACC1 과 [10] [11] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000175216 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000040549 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1" . DNA Res . 2 (1): 37–43. doi :10.1093/dnares/2.1.37 PMID 7788527 . ^ Charrasse S, Mazel M, Taviaux S, Berta P, Chow T, Larroque C (Feb 1996). "Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors". Eur. J. Biochem . 234 (2): 406–13. doi :10.1111/j.1432-1033.1995.406_b.x . PMID 8536682 . ^ "Entrez Gene: CKAP5 cytoskeleton associated protein 5" .^ Cassimeris L, Morabito J (2004). "TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly" . Mol. Biol. Cell . 15 (4): 1580–90. doi :10.1091/mbc.E03-07-0544 . PMC 379257 PMID 14718566 . ^ Barr AR, Gergely F (2008). "MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics" . Mol. Cell. Biol . 28 (23): 7199–211. doi :10.1128/MCB.01040-08 . PMC 2593372 PMID 18809577 . ^ Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer" . Oncogene . 22 (50): 8102–16. doi :10.1038/sj.onc.1206972 PMID 14603251 . ^ Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH (Apr 2002). "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells" . Biochem. J . 363 (Pt 1): 195–200. doi :10.1042/0264-6021:3630195 . PMC 1222467 PMID 11903063 .
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