Cep192 로도 알려진 192kDa의 중심체 단백질 은 CEP192 [5] [6] 단백질 이다.그것 은 C. elegans 와 D. melanogaster 유전자 SPD-2의 [7]
Cep192는 포유동물 [7] 극주위 물질 모집, 중심체 성숙 및 중심체 증식의 주요 조절제이다. 그것 은 감마 튜브린 고리 복합체와 미소관 핵형성과 방추 조립에 관여하는 다른 단백질이 유사분열 [8]
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000101639 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000024542 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: centrosomal protein 192kDa" .^ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature . 426 (6966): 570–4. doi :10.1038/nature02166 . PMID 14654843 . S2CID 4427303 . ^ a b Zhu, F.; Lawo, S.; Bird, A.; Pinchev, D.; Ralph, A.; Richter, C.; Müller-Reichert, T.; Kittler, R.; Hyman, A.; Pelletier, L. (2008). "The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis" . Current Biology . 18 (2): 136–141. doi :10.1016/j.cub.2007.12.055 PMID 18207742 . S2CID 16159409 . ^ Gomez-Ferreria, M.; Rath, U.; Buster, D.; Chanda, S.; Caldwell, J.; Rines, D.; Sharp, D. (2007). "Human Cep192 is required for mitotic centrosome and spindle assembly" . Current Biology . 17 (22): 1960–1966. doi :10.1016/j.cub.2007.10.019 PMID 17980596 . S2CID 10245690 . 외부 링크 추가 정보 Nagase T, Kikuno R, Nakayama M, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 7 (4): 273–81. doi :10.1093/dnares/7.4.271 PMID 10997877 . Golsteyn RM, Mundt KE, Fry AM, Nigg EA (1995). "Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function" . J. Cell Biol . 129 (6): 1617–28. doi :10.1083/jcb.129.6.1617 . PMC 2291169 PMID 7790358 . Zhu F, Lawo S, Bird A, et al. (2008). "The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis" . Curr. Biol . 18 (2): 136–41. doi :10.1016/j.cub.2007.12.055 PMID 18207742 . S2CID 16159409 . Gomez-Ferreria MA, Rath U, Buster DW, et al. (2007). "Human Cep192 is required for mitotic centrosome and spindle assembly" . Curr. Biol . 17 (22): 1960–6. doi :10.1016/j.cub.2007.10.019 PMID 17980596 . S2CID 10245690 . Mayor T, Stierhof YD, Tanaka K, et al. (2000). "The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion" . J. Cell Biol . 151 (4): 837–46. doi :10.1083/jcb.151.4.837 . PMC 2169446 PMID 11076968 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs" . Genome Res . 11 (3): 422–35. doi :10.1101/gr.GR1547R . PMC 311072 PMID 11230166 . Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). "Defining the Human Deubiquitinating Enzyme Interaction Landscape" . Cell . 138 (2): 389–403. doi :10.1016/j.cell.2009.04.042 . PMC 2716422 PMID 19615732 . Takahashi M, Yamagiwa A, Nishimura T, et al. (2002). "Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex" . Mol. Biol. Cell . 13 (9): 3235–45. doi :10.1091/mbc.E02-02-0112 . PMC 124155 PMID 12221128 . Casenghi M, Meraldi P, Weinhart U, et al. (2003). "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation" . Dev. Cell . 5 (1): 113–25. doi :10.1016/S1534-5807(03)00193-X PMID 12852856 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Petretti C, Savoian M, Montembault E, et al. (2006). "The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation" . EMBO Rep . 7 (4): 418–24. doi :10.1038/sj.embor.7400639 . PMC 1456919 PMID 16462731 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol . 94 (1–3): 203–8. doi :10.1016/j.jsbmb.2005.01.007 . PMID 15862967 . S2CID 9746088 .
