UGCG

UGCG
식별자
별칭	UGCG, GCS, GLCT1, UDP-글루코세라마이드 글루코실트전달효소
외부 ID	OMIM: 602874 MGI: 1332243 HomoloGene: 37763 GeneCard: UGCG
유전자 위치(인간)
쳇.	9번 염색체(인간)
끝	111,935,369 bp
유전자 위치(마우스)
쳇.	4번 염색체(쥐)
끝	59,195,833 bp
RNA 표현 패턴
	표현된 상단
	골수; ; 뱃속; ; 부신 피질; ; 난소의; ; 폐골.; ; 부신;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	글리코실전달효소 활성; 전이효소 활동; 세라마이드 글루코실전달효소 활성; 디히드로세라마이드 글루코실전달효소 활성; GO:0001948 단백질 결합;
셀룰러 컴포넌트	막의 적분 성분; 골지막; 골지 기구; 막으로 막다;
생물학적 과정	글리코스포싱올리피드 생합성 과정; 글리코스포싱올리피드 대사 과정; 글루코실세라마이드생합성공정; 표피 발달; 지질 대사; 스핑골리피드 대사 과정; 세포 분화; 뉴런 발달; 피부 장벽 설치; 장내 지질 흡수; 단백질 지방화; 신호 전달 조절; 각질 세포 분화; 렙틴 매개 신호 경로; 옥수수 가루로 만든 봉투 조립품;
	출처:아미고 / 퀵고
직교체
	7357
	22234
	ENSG00000148154
	ENSMUSG00000028381
	Q16739
	O88693
	NM_003358
	NM_011673
	NP_003349; NP_003349.1
	NP_035803
	위키다타
인간 보기/편집	마우스 보기/편집

세라마이드 글루코실전달효소는 인간에서 UGCG 유전자에 의해 암호화된 효소다.^[5]^[6]^[7]null

글리코스포싱올리피드(GSLs)는 지질 및 설탕 모이티(Moietie)를 함유한 막 성분의 그룹이다.그것들은 본질적으로 모든 동물 세포에 존재하며 다양한 세포 과정에서 중요한 역할을 한다고 믿어진다.UDP-글루코세라마이드 글루코실트전달효소는 글리코실화 단계 중 첫 번째 글리코실화 단계를 촉진한다.glucosylceramide라는 제품은 300 GSL 이상의 핵심 구조다.UGCG는 널리 표현되며 각질세포 분화 시 전사가 조절된다.^[7]null

상호작용

UGCG는 RTN1과 상호작용하는 것으로 나타났다.^[8]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000148154 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000028381 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ichikawa S, Sakiyama H, Suzuki G, Hidari KI, Hirabayashi Y (Jul 1996). "Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis". Proc Natl Acad Sci U S A. 93 (10): 4638–4643. Bibcode:1996PNAS...93.4638I. doi:10.1073/pnas.93.10.4638. PMC 39331. PMID 8643456.
^ Ichikawa S, Ozawa K, Hirabayashi Y (Jun 1998). "Assignment of a UDP-glucose:ceramide glucosyltransferase gene (UGCG) to human chromosome band 9q31 by in situ hybridization". Cytogenet Cell Genet. 79 (3–4): 233–234. doi:10.1159/000134731. PMID 9605861.
^ ^a ^b "Entrez Gene: UGCG UDP-glucose ceramide glucosyltransferase".
^ Di Sano, Federica; Fazi Barbara; Citro Gennaro; Lovat Penny E; Cesareni Gianni; Piacentini Mauro (Jul 2003). "Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells". Cancer Res. 63 (14): 3860–3865. ISSN 0008-5472. PMID 12873973.

추가 읽기

Kohyama-Koganaya A, Hirabayashi Y (2002). "[Role of glucosylceramide synthase as negative regulator for ceramide]". Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 470–475. PMID 11915344.
Matsuo N, Nomura T, Imokawa G (1992). "A rapid and simple assay method for UDP-glucose:ceramide glucosyltransferase". Biochim. Biophys. Acta. 1116 (2): 97–103. doi:10.1016/0304-4165(92)90105-4. PMID 1533793.
Ichikawa S, Sakiyama H, Suzuki G, et al. (1996). "Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 4638–4643. Bibcode:1996PNAS...93.4638I. doi:10.1073/pnas.93.10.4638. PMC 38048. PMID 8901638.
Watanabe R, Wu K, Paul P, et al. (1998). "Up-regulation of glucosylceramide synthase expression and activity during human keratinocyte differentiation". J. Biol. Chem. 273 (16): 9651–9655. doi:10.1074/jbc.273.16.9651. PMID 9545298.
Tepper AD, Diks SH, van Blitterswijk WJ, Borst J (2000). "Glucosylceramide synthase does not attenuate the ceramide pool accumulating during apoptosis induced by CD95 or anti-cancer regimens". J. Biol. Chem. 275 (44): 34810–34817. doi:10.1074/jbc.M005142200. PMID 10945987.
Ogretmen B, Schady D, Usta J, et al. (2001). "Role of ceramide in mediating the inhibition of telomerase activity in A549 human lung adenocarcinoma cells". J. Biol. Chem. 276 (27): 24901–24910. doi:10.1074/jbc.M100314200. PMID 11335714.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Di Sano F, Fazi B, Citro G, et al. (2003). "Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells". Cancer Res. 63 (14): 3860–3865. PMID 12873973.
Grazide S, Terrisse AD, Lerouge S, et al. (2004). "Cytoprotective effect of glucosylceramide synthase inhibition against daunorubicin-induced apoptosis in human leukemic cell lines". J. Biol. Chem. 279 (18): 18256–18261. doi:10.1074/jbc.M314105200. PMID 14766899.
Norris-Cervetto E, Callaghan R, Platt FM, et al. (2004). "Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells". J. Biol. Chem. 279 (39): 40412–40418. doi:10.1074/jbc.M404466200. PMID 15263008.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Turzanski J, Grundy M, Shang S, et al. (2005). "P-glycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway". Exp. Hematol. 33 (1): 62–72. doi:10.1016/j.exphem.2004.10.005. PMID 15661399.
Sun NN, Fastje CD, Wong SS, et al. (2005). "Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line". Toxicology and Industrial Health. 19 (7–10): 157–163. doi:10.1191/0748233703th185oa. PMID 15747776. S2CID 14394243.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Fazi B, Melino S, Di Sano F, et al. (2006). "Cloning, expression, and preliminary structural characterization of RTN-1C". Biochem. Biophys. Res. Commun. 342 (3): 881–886. doi:10.1016/j.bbrc.2006.02.036. PMID 16500619.

9번 염색체의 유전자에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000148154 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000028381 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8643456-5] Ichikawa S, Sakiyama H, Suzuki G, Hidari KI, Hirabayashi Y (Jul 1996). "Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis". Proc Natl Acad Sci U S A. 93 (10): 4638–4643. Bibcode:1996PNAS...93.4638I. doi:10.1073/pnas.93.10.4638. PMC 39331. PMID 8643456.

[pmid9605861-6] Ichikawa S, Ozawa K, Hirabayashi Y (Jun 1998). "Assignment of a UDP-glucose:ceramide glucosyltransferase gene (UGCG) to human chromosome band 9q31 by in situ hybridization". Cytogenet Cell Genet. 79 (3–4): 233–234. doi:10.1159/000134731. PMID 9605861.

[entrez-7] "Entrez Gene: UGCG UDP-glucose ceramide glucosyltransferase".

[pmid12873973-8] Di Sano, Federica; Fazi Barbara; Citro Gennaro; Lovat Penny E; Cesareni Gianni; Piacentini Mauro (Jul 2003). "Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells". Cancer Res. 63 (14): 3860–3865. ISSN 0008-5472. PMID 12873973.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

Search

UGCG

네임스페이스

더

상호작용

참조

추가 읽기