TRRAP 라고도 알려진 변형/전사 도메인 관련 단백질 은 인간 에서 TRRAP [5] [6] 단백질 이다.TRRAP은 포스파티딜이노시톨 3-키나아제 관련 키나아제 단백질군에 속한다.
기능. TRRAP은 어댑터 단백질로 히스톤 아세틸전달효소 활성(HAT)을 가진 다양한 다단백질 크로마틴 복합체에서 발견되며, 후생유전자 전사 활성화를 담당한다. TRRAP은 MYC (c-Myc) 전사 활성화에 중심적인 역할을 하며 MYC에 의한 세포 변환에도 참여합니다. p53/TP53- , E2F1- 및 E2F4에 의한 문자 변환의 액티브화에 필요합니다. 그것은 또한 주요 [7] 온코프로틴 인 아데노바이러스 E1A에 의해 매개되는 전사 활성화에 관여한다.
TRRAP은 또한 유사분열 체크포인트 와 정상적 인 세포주기 진행에도 필요하다. MRN 복합체(MRE11 , RAD50 및 NBS1 )는 DNA Double-Strand Break(DSB; 이중 스트랜드 절단 ) 검출 및 복구에 관여합니다.TRRAP은 MRN 복합체와 관련되며 TRRAP이 제거되면 복합체는 cDNA 말단 결합 활성을 감소시킨다. 따라서 TRRAP은 DSB 복구와 염색질 리모델링 [8] [9]
모델 유기체 트랩녹아웃쥐표현형 모델 유기체는 TRRAP 기능의 연구에 사용되어 왔다.Trrap 이라고tm1a(EUCOMM)Wtsi [15] [16] 불리는 조건부 녹아웃 마우스 라인 은 International Knockout Mouse Consortium 프로그램의 일부로 생성되었습니다.이것 은 관심 있는 과학자들에게 [17] [18] [19]
수컷과 암컷은 표준화된 표현형 검사를 통해 [13] [20] 돌연변이 생쥐에 대해 24개의 검사가 수행되었고 2개의 유의한 이상이 [13] 임신 기간 동안 동종 돌연변이 배아는 확인되지 않았고, 따라서 젖을 뺄 때까지 생존한 배아는 없었다. 나머지 테스트는 헤테로 접합 돌연변이 성인 생쥐를 대상으로 수행되었으며, 이 [13]
상호 작용 변환/전사 도메인 관련 단백질은 다음과 상호작용하는 것 으로 나타났다.
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