4-히드록시-3-메틸하지만-2-에닐 디포스포산 환원효소
4-Hydroxy-3-methylbut-2-enyl diphosphate reductase| 4-히드록시-3-메틸하지만-2-에닐 디포스포산 환원효소 | |||||||||
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| 식별자 | |||||||||
| EC 번호 | 1.17.1.2 | ||||||||
| CAS 번호. | 512789-14-9 | ||||||||
| 데이터베이스 | |||||||||
| 인텐츠 | IntEnz 뷰 | ||||||||
| 브렌다 | 브렌다 입력 | ||||||||
| 엑스퍼시 | 나이스자이메 뷰 | ||||||||
| 케그 | KEG 입력 | ||||||||
| 메타사이크 | 대사통로 | ||||||||
| 프리암 | 프로필 | ||||||||
| PDB 구조 | RCSB PDB PDBe PDBsum | ||||||||
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4-히드록시-3-메틸하지만-2-에닐 디프인산염 환원효소(EC 1.17.1.2, 이소펜테닐-디프인산염:NADP+ 산화효소, LytB, (E)-4-히드록시-3-메틸 하지만-2-en-1-yl diphosphate reducatease, HMBPP 환원효소, IspH, LytB/IspH)는 비메발론산 경로에 있는 효소다.(E)-4-히드록시-3-메틸-그러나-2-에닐 파이로인산염(또는 "HMB-PP")[1][2][3][4][5][6]에 작용한다.
- (1) 이소펜테닐 디프인산 + NAD(P)+ + HO2 ⇌E)-4-히드로시-3-메틸 그러나-2-en-1-yl diphosphate + NAD(P)H+ + H
- (2) dimethylall diphosphate + NAD(P)+ + HO ho2 E)-4-hydroxy-3-methyl but-2-en-1-yl diphosphate + NAD(P)H+ + H
4-히드록시-3-메틸하지만-2-에닐 디프인산 환원효소는 [3Fe-4S] 또는 [4Fe-4S] 군집을 포함하는 철황 단백질이다.
참조
- ^ Rohdich F, Hecht S, Gärtner K, Adam P, Krieger C, Amslinger S, Arigoni D, Bacher A, Eisenreich W (February 2002). "Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein". Proceedings of the National Academy of Sciences of the United States of America. 99 (3): 1158–63. Bibcode:2002PNAS...99.1158R. doi:10.1073/pnas.032658999. PMC 122160. PMID 11818558.
- ^ Hintz M, Reichenberg A, Altincicek B, Bahr U, Gschwind RM, Kollas AK, Beck E, Wiesner J, Eberl M, Jomaa H (December 2001). "Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli". FEBS Letters. 509 (2): 317–22. doi:10.1016/s0014-5793(01)03191-x. PMID 11741609.
- ^ Charon, L.; Pale-Grosdemange, C.; Rohmer, M. (1999). "On the reduction steps in the mevalonate independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis in the bacterium Zymomonas mobilis". Tetrahedron Lett. 40 (40): 7231–7234. doi:10.1016/s0040-4039(99)01531-2.
- ^ Röhrich RC, Englert N, Troschke K, Reichenberg A, Hintz M, Seeber F, Balconi E, Aliverti A, Zanetti G, Köhler U, Pfeiffer M, Beck E, Jomaa H, Wiesner J (November 2005). "Reconstitution of an apicoplast-localised electron transfer pathway involved in the isoprenoid biosynthesis of Plasmodium falciparum". FEBS Letters. 579 (28): 6433–8. doi:10.1016/j.febslet.2005.10.037. PMID 16289098.
- ^ Wolff M, Seemann M, Tse Sum Bui B, Frapart Y, Tritsch D, Garcia Estrabot A, Rodríguez-Concepción M, Boronat A, Marquet A, Rohmer M (April 2003). "Isoprenoid biosynthesis via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase (LytB/IspH) from Escherichia coli is a [4Fe-4S] protein". FEBS Letters. 541 (1–3): 115–20. doi:10.1016/s0014-5793(03)00317-x. PMID 12706830.
- ^ Gräwert T, Kaiser J, Zepeck F, Laupitz R, Hecht S, Amslinger S, Schramek N, Schleicher E, Weber S, Haslbeck M, Buchner J, Rieder C, Arigoni D, Bacher A, Eisenreich W, Rohdich F (October 2004). "IspH protein of Escherichia coli: studies on iron-sulfur cluster implementation and catalysis". Journal of the American Chemical Society. 126 (40): 12847–55. doi:10.1021/ja0471727. PMID 15469281.
