센트로메어 단백질 B는 주요 센트로메어 자가항원 B로도 알려져 있으며 세포핵 의 자가항원 단백질이다.인간에서 센트로메어 단백질 B는 CENPB 유전자에 [5] [6] [7]
기능. 센트로미어 단백질 B는 센트로미어 형성을 촉진하는 고도로 보존된 단백질이다. 포고 DNA 트랜스포존 계열의 트랜스포사아제로부터 파생된 DNA 결합 단백질이다. N 말단에 나선-루프-나선 DNA 결합 모티브, C 말단에 이합체화 도메인을 포함한다. DNA 결합 도메인은 중심체 알파 위성 DNA에서 17-bp 배열(CENP-B 박스)을 인식하고 결합합니다. 이 단백질은 상간핵과 유사분열 염색체의 특정 동원체 구조의 조립에 중요한 역할을 하도록 제안되었다. 또한 항중심미어 항체를 가진 환자로부터 혈청에 의해 인식되는 주요 동원체 자가항원으로 간주된다.
임상적 의의 동원체 단백질 B는 소세포 폐암 의 잠재적 [8]
「 」를 참조해 주세요. 레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000125817 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000068267 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: centromere protein B" .^ Sugimoto K, Yata H, Himeno M (July 1993). "Mapping of the human CENP-B gene to chromosome 20 and the CENP-C gene to chromosome 12 by a rapid cycle DNA amplification procedure". Genomics . 17 (1): 240–2. doi :10.1006/geno.1993.1312 . PMID 8406460 . ^ Ando S, Yang H, Nozaki N, Okazaki T, Yoda K (April 2002). "CENP-A, -B, and -C chromatin complex that contains the I-type alpha-satellite array constitutes the prekinetochore in HeLa cells" . Molecular and Cellular Biology . 22 (7): 2229–41. doi :10.1128/MCB.22.7.2229-2241.2002 . PMC 133672 PMID 11884609 . ^ Briasoulis E, Kamposioras K, Tzovaras V, Pafitanis G, Kostoula A, Mavridis A, Pavlidis N (May 2008). "CENP-B specific anti-centromere autoantibodies heralding small-cell lung cancer. A case study and review of the literature". Lung Cancer . 60 (2): 302–6. doi :10.1016/j.lungcan.2007.09.014 . PMID 17980453 .
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PDB 갤러리
1bw6 : 인간 센트로메어 단백질 B(CENP-B) DNA 결합 도메인 RP1
1hlv : CENP-B박스 DNA와 복합된 CENP-B(1~129)의 결정구조
1ufi : 인간 CENP-B의 이량화 영역의 결정 구조
기본의 개념 종류들 과정 및 진화 구조물들
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이 기사에는 미국 국립 의학 도서관 (미국 국립 의학 도서관 )의 공공 도메인 텍스트가 포함되어 있습니다.
