WNT11
WNT11
단백질 Wnt-11은 인간의 WNT11 [5][6]유전자에 의해 암호화되는 단백질이다.
WNT 유전자 패밀리는 분비된 시그널링 단백질을 코드하는 구조적으로 관련된 유전자로 구성되어 있습니다.이 단백질들은 종양 발생과 세포 운명의 조절과 배아 발생 동안의 패턴 형성 등 여러 발달 과정에 관여되어 왔다.이 유전자는 WNT 유전자군의 일원입니다.아미노산 정체성을 나타내는 단백질을 마우스, 닭, 제노푸스 Wnt11 단백질로 각각 97%, 85%, 63% 암호화한다.이 유전자는 골격, 신장, 폐의 발달에 역할을 할 수 있으며, 고골질량증후군의 [6]유력한 후보 유전자로 여겨진다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000085741 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000015957 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Lako M, Strachan T, Bullen P, Wilson DI, Robson SC, Lindsay S (Dec 1998). "Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung". Gene. 219 (1–2): 101–10. doi:10.1016/S0378-1119(98)00393-X. PMID 9757009.
- ^ a b "Entrez Gene: WNT11 wingless-type MMTV integration site family, member 11".
추가 정보
- Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC 275763. PMID 8167409.
- Kirikoshi H, Sekihara H, Katoh M (2002). "Molecular cloning and characterization of human WNT11". Int. J. Mol. Med. 8 (6): 651–6. doi:10.3892/ijmm.8.6.651. PMID 11712081.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ouko L; Ziegler TR; Gu LH; et al. (2004). "Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells". J. Biol. Chem. 279 (25): 26707–15. doi:10.1074/jbc.M402877200. PMC 1351009. PMID 15084607.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kim SW; Park JI; Spring CM; et al. (2005). "Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin". Nat. Cell Biol. 6 (12): 1212–20. doi:10.1038/ncb1191. PMID 15543138. S2CID 19404686.
- Koyanagi M; Haendeler J; Badorff C; et al. (2005). "Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells". J. Biol. Chem. 280 (17): 16838–42. doi:10.1074/jbc.M500323200. PMID 15701629.
- Garriock RJ, D'Agostino SL, Pilcher KC, Krieg PA (2005). "Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus". Dev. Biol. 279 (1): 179–92. doi:10.1016/j.ydbio.2004.12.013. PMID 15708567.
- Otsuki T; Ota T; Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Panáková D, Werdich AA, Macrae CA (2010). "Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel". Nature. 466 (8): 874–878. doi:10.1038/nature09249. PMC 2921013. PMID 20657579.
