신경내분비 단백질 7B2는 인간에서 SCG5gene에 의해 암호화된 단백질이다.[5][6][7]이 유전자에 의해 발현된 단백질은 신경내분비 조직에 널리 분포되어 있다.이 단백질의 집적을 차단하여 프로프로테인 변환효소 PC2의 체세포단백질 역할을 하며, 활성 PC2 효소의 생산에 필요하다.[8][9]그것은 본질적으로 질서 정연한 단백질로서 proPC2 외에 다른 종합 분비 단백질에 대한 보호막 역할을 할 수도 있다(Helwig et al. 2013).7B2는 척추동물과 무척추동물에서 평충(단백질 ID: AIZ72728.1)과 곤충에서 확인되었다. PMID10749852).Sgne1과 Secretogranin V로도 불린다.씨.엘레건에서는 원래 e7B2(PMID972625)라고 불렸으며, 그 후 세븐 B 2(gene name sbt-1)로 개칭했다.이 단백질에 대한 Pfam 항목이 있다. 시큐러닌_V(PF05281)
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lloyd RV, Jin L (March 1994). "Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas". Diagnostic Molecular Pathology. 3 (1): 38–45. doi:10.1097/00019606-199403010-00007. PMID8162254.
^Taupenot L, Harper KL, O'Connor DT (March 2003). "The chromogranin-secretogranin family". The New England Journal of Medicine. 348 (12): 1134–49. doi:10.1056/NEJMra021405. PMID12646671.
Paquet L, Lazure C, Seidah NG, Chrétien M, Mbikay M (January 1991). "The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man". Biochemical and Biophysical Research Communications. 174 (1): 156–62. doi:10.1016/0006-291X(91)90499-W. PMID1989596.
Roebroek AJ, Dehaen MR, van Bokhoven A, Martens GJ, Marÿnen P, van den Berghe H, Van de Ven WJ (1989). "Regional mapping of the human gene encoding the novel pituitary polypeptide 7B2 to chromosome 15q13----q14 by in situ hybridization". Cytogenetics and Cell Genetics. 50 (2–3): 158–60. doi:10.1159/000132749. PMID2776483.
Benjannet S, Marcinkiewicz M, Falgueyret JP, Johnson DE, Seidah NG, Chrétien M (August 1988). "Secretory protein 7B2 is associated with pancreatic hormones within normal islets and some experimentally induced tumors". Endocrinology. 123 (2): 874–84. doi:10.1210/endo-123-2-874. PMID2840270.
Brayton KA, Aimi J, Qiu H, Yazdanparast R, Ghatei MA, Polak JM, et al. (December 1988). "Cloning, characterization, and sequence of a porcine cDNA encoding a secreted neuronal and endocrine protein". DNA. 7 (10): 713–9. doi:10.1089/dna.1988.7.713. PMID3234177.
Marcinkiewicz M, Benjannet S, Falgueyret JP, Seidah NG, Schürch W, Verdy M, et al. (August 1988). "Identification and localization of 7B2 protein in human, porcine, and rat thyroid gland and in human medullary carcinoma". Endocrinology. 123 (2): 866–73. doi:10.1210/endo-123-2-866. PMID3293987.
Marcinkiewicz M, Benjannet S, Cantin M, Seidah NG, Chrétien M (August 1986). "CNS distribution of a novel pituitary protein '7B2': localization in secretory and synaptic vesicles". Brain Research. 380 (2): 349–56. doi:10.1016/0006-8993(86)90233-7. PMID3530373. S2CID22326257.
Seidah NG, Hsi KL, De Serres G, Rochemont J, Hamelin J, Antakly T, et al. (September 1983). "Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily. Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus". Archives of Biochemistry and Biophysics. 225 (2): 525–34. doi:10.1016/0003-9861(83)90063-2. PMID6625600.
Benjannet S, Savaria D, Chrétien M, Seidah NG (May 1995). "7B2 is a specific intracellular binding protein of the prohormone convertase PC2". Journal of Neurochemistry. 64 (5): 2303–11. doi:10.1046/j.1471-4159.1995.64052303.x. PMID7722516. S2CID7133644.
Braks JA, Martens GJ (July 1994). "7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway". Cell. 78 (2): 263–73. doi:10.1016/0092-8674(94)90296-8. PMID7913882. S2CID24734254.
