mir-451 마이크로RNA
mir-451 microRNA| 미르-451 | |
|---|---|
 miR-451 마이크로RNA 2차 구조 및 배열 보존 | |
| 식별자 | |
| 기호. | 미르-451 |
| Rfam | RF00722 |
| miRBase 패밀리 | MIPF0000148 |
| 옴 | 612071 |
| 기타 데이터 | |
| RNA형 | 마이크로RNA |
| 도메인 | 진핵생물;척추동물 |
| PDB 구조 | PDBe |
분자생물학에서 mir-451 마이크로RNA는 짧은 RNA 분자이다.마이크로 RNA는 여러 가지 메커니즘에 의해 다른 유전자의 발현 수준을 조절하는 기능을 한다.
miR-451은 약물-수송 단백질 P-글리코프로틴을 조절하여 화학요법제인 Paclitaxel에 [1]대한 내성을 잠재적으로 촉진한다.
적용들
개념 증명 실험은 miR-451과 mir-126, mir-150이 법의학에서 혈액과 타액 [2]샘플을 구별하기 위해 사용될 수 있다는 것을 보여주었다.이것은 다른 조직 [2]유형에서 miRNA의 다른 miRNA 프로파일에 의해 가능합니다.
레퍼런스
- ^ van Jaarsveld, MT; Helleman, J; Berns, EM; Wiemer, EA (August 2010). "MicroRNAs in ovarian cancer biology and therapy resistance". The International Journal of Biochemistry & Cell Biology. 42 (8): 1282–1290. doi:10.1016/j.biocel.2010.01.014. PMID 20083225.
- ^ a b Courts, C; Madea, B (Aug 9, 2011). "Specific Micro-RNA Signatures for the Detection of Saliva and Blood in Forensic Body-fluid Identification". Journal of Forensic Sciences. 56 (6): 1464–1470. doi:10.1111/j.1556-4029.2011.01894.x. PMID 21827476. S2CID 41948164.
추가 정보
- Yang JS, Maurin T, Robine N, Rasmussen KD, Jeffrey KL, Chandwani R, Papapetrou EP, Sadelain M, O'Carroll D, Lai EC (2010). "Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis". Proc Natl Acad Sci U S A. 107 (34): 15163–15168. Bibcode:2010PNAS..10715163Y. doi:10.1073/pnas.1006432107. PMC 2930549. PMID 20699384.
- Yu D, dos Santos CO, Zhao G, Jiang J, Amigo JD, Khandros E, Dore LC, Yao Y, D'Souza J, Zhang Z, Ghaffari S, Choi J, Friend S, Tong W, Orange JS, Paw BH, Weiss MJ (2010). "miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta". Genes Dev. 24 (15): 1620–1633. doi:10.1101/gad.1942110. PMC 2912560. PMID 20679398.
- Patrick DM, Zhang CC, Tao Y, Yao H, Qi X, Schwartz RJ, Jun-Shen Huang L, Olson EN (2010). "Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta". Genes Dev. 24 (15): 1614–1619. doi:10.1101/gad.1942810. PMC 2912559. PMID 20679397.
- Godlewski J, Bronisz A, Nowicki MO, Chiocca EA, Lawler S (2010). "microRNA-451: A conditional switch controlling glioma cell proliferation and migration". Cell Cycle. 9 (14): 2742–2748. doi:10.4161/cc.9.14.12248. PMID 20647762.
- Svasti S, Masaki S, Penglong T, Abe Y, Winichagoon P, Fucharoen S, Umemura T (2010). "Expression of microRNA-451 in normal and thalassemic erythropoiesis". Ann Hematol. 89 (10): 953–958. doi:10.1007/s00277-010-0980-7. PMID 20461517. S2CID 35296680.
- Godlewski J, Nowicki MO, Bronisz A, Nuovo G, Palatini J, De Lay M, Van Brocklyn J, Ostrowski MC, Chiocca EA, Lawler SE (2010). "MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells". Mol Cell. 37 (5): 620–632. doi:10.1016/j.molcel.2010.02.018. PMC 3125113. PMID 20227367.
- Bruchova-Votavova H, Yoon D, Prchal JT (2010). "miR-451 enhances erythroid differentiation in K562 cells". Leuk Lymphoma. 51 (4): 686–693. doi:10.3109/10428191003629362. PMID 20218812. S2CID 36579523.
- Tsuchiya S, Oku M, Imanaka Y, Kunimoto R, Okuno Y, Terasawa K, Sato F, Tsujimoto G, Shimizu K (2009). "MicroRNA-338-3p and microRNA-451 contribute to the formation of basolateral polarity in epithelial cells". Nucleic Acids Res. 37 (11): 3821–3827. doi:10.1093/nar/gkp255. PMC 2699527. PMID 19386621.
- Bandres E, Bitarte N, Arias F, Agorreta J, Fortes P, Agirre X, Zarate R, Diaz-Gonzalez JA, Ramirez N, Sola JJ, Jimenez P, Rodriguez J, Garcia-Foncillas J (2009). "microRNA-451 regulates macrophage migration inhibitory factor production and proliferation of gastrointestinal cancer cells". Clin Cancer Res. 15 (7): 2281–2290. doi:10.1158/1078-0432.CCR-08-1818. PMID 19318487.
- Pase L, Layton JE, Kloosterman WP, Carradice D, Waterhouse PM, Lieschke GJ (2009). "miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2". Blood. 113 (8): 1794–1804. doi:10.1182/blood-2008-05-155812. PMC 2647672. PMID 18849488.
- Gal H, Pandi G, Kanner AA, Ram Z, Lithwick-Yanai G, Amariglio N, Rechavi G, Givol D (2008). "MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells". Biochem Biophys Res Commun. 376 (1): 86–90. doi:10.1016/j.bbrc.2008.08.107. PMID 18765229.
- Kovalchuk O, Filkowski J, Meservy J, Ilnytskyy Y, Tryndyak VP, Chekhun VF, Pogribny IP (2008). "Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin". Mol Cancer Ther. 7 (7): 2152–2159. doi:10.1158/1535-7163.MCT-08-0021. PMID 18645025.
- Zhu H, Wu H, Liu X, Evans BR, Medina DJ, Liu CG, Yang JM (2008). "Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells". Biochem Pharmacol. 76 (5): 582–588. doi:10.1016/j.bcp.2008.06.007. PMC 2628586. PMID 18619946.
외부 링크
- Rfam의 mir-451 microRNA 전구체 패밀리 페이지
- "MicroRNA MIR451 family (MIR451) Gene group". HUGO Gene Nomenclature Committee (HGNC).
