VTCN1

VTCN1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	4GOS
식별자
에일리어스	T세포활성화억제제 1, T세포활성화억제제 1을 포함한 VTCN1, B7H4, B7S1, B7H.5, PRO121, VCTN1, V세트 도메인, T세포활성화억제제제 1을 포함한 V세트 도메인
외부 ID	OMIM : 608162 MGI : 3039619 HomoloGene : 11627 GenCard : VTCN1
유전자 위치(인간)
크르.	1번 염색체(인간)
끝.	117,210,960 bp
유전자 위치(마우스)
크르.	3번 염색체(마우스)
끝.	100,804,238 bp
RNA발현패턴
	상단 표시 위치:
	안검결막; ; 유즙관; ; 모낭; ; 우측 자궁관; ; 랑게르한스 섬; ; 췌장체; ; 이차 난모세포; ; 양수; ; 소침샘; ; 기관;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	신호수용체결합; 분자 기능;
셀룰러 컴포넌트	막의 적분 성분; 혈장막; 막; 혈장막외측;
생물학적 과정	적응 면역 반응; T세포 증식의 양성 조절; 원생 동물에 대한 반응; 면역계 과정; T세포 증식의 음성 조절; 아포토시스 과정의 음성 조절; T세포활성화음성조절; 면역 반응 조절; T세포수용체신호경로;
	출처:아미고 / QuickGO
맞춤법
	79679
	242122
	ENSG00000134258
	ENSMUSG000051076
	Q7Z7D3
	Q7TSP5
	NM_001253849; NM_001253850; NM_024626
	NM_178594
	NP_001240778; NP_001240779; NP_078902
	NP_848709
	위키데이터
인간 보기/편집	마우스 표시/편집

V-set 도메인 함유 T세포 활성화 억제제 1은 VTCN1 유전자에 ^[5]^[6]^[7]의해 인체 내에서 암호화되는 단백질이다.

기능.

B7H4는 B7 계열의 늑장 자극 단백질에 속합니다(CD80; MIM 112203 참조).이러한 단백질은 항원 제시 세포의 표면에서 발현되며, T 림프구의 리간드(예: CD28; MIM 186760)와 상호작용한다.[OMIM ^[7]제공]

B7-H4는 면역 검사점 분자입니다.

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B7(단백질)

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000134258 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000051076 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sica GL, Choi IH, Zhu G, Tamada K, Wang SD, Tamura H, Chapoval AI, Flies DB, Bajorath J, Chen L (June 2003). "B7-H4, a molecule of the B7 family, negatively regulates T cell immunity". Immunity. 18 (6): 849–61. doi:10.1016/S1074-7613(03)00152-3. PMID 12818165.
^ Prasad DV, Richards S, Mai XM, Dong C (June 2003). "B7S1, a novel B7 family member that negatively regulates T cell activation". Immunity. 18 (6): 863–73. doi:10.1016/S1074-7613(03)00147-X. PMID 12818166.
^ ^a ^b "Entrez Gene: VTCN1 V-set domain containing T cell activation inhibitor 1".

추가 정보

Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla MA, Zimmerman N, Sim J, Zang X, Murphy TL, Russell JH, Allison JP, Murphy KM (July 2003). "BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1". Nature Immunology. 4 (7): 670–9. doi:10.1038/ni944. PMID 12796776. S2CID 11943145.
Zang X, Loke P, Kim J, Murphy K, Waitz R, Allison JP (September 2003). "B7x: a widely expressed B7 family member that inhibits T cell activation". Proceedings of the National Academy of Sciences of the United States of America. 100 (18): 10388–92. Bibcode:2003PNAS..10010388Z. doi:10.1073/pnas.1434299100. PMC 193571. PMID 12920180.
Choi IH, Zhu G, Sica GL, Strome SE, Cheville JC, Lau JS, Zhu Y, Flies DB, Tamada K, Chen L (November 2003). "Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family". Journal of Immunology. 171 (9): 4650–4. doi:10.4049/jimmunol.171.9.4650. PMID 14568939.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Salceda S, Tang T, Kmet M, Munteanu A, Ghosh M, Macina R, Liu W, Pilkington G, Papkoff J (May 2005). "The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation". Experimental Cell Research. 306 (1): 128–41. doi:10.1016/j.yexcr.2005.01.018. PMID 15878339.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Kryczek I, Zou L, Rodriguez P, Zhu G, Wei S, Mottram P, Brumlik M, Cheng P, Curiel T, Myers L, Lackner A, Alvarez X, Ochoa A, Chen L, Zou W (April 2006). "B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma". The Journal of Experimental Medicine. 203 (4): 871–81. doi:10.1084/jem.20050930. PMC 2118300. PMID 16606666.
Kryczek I, Wei S, Zou L, Zhu G, Mottram P, Xu H, Chen L, Zou W (July 2006). "Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells". Journal of Immunology. 177 (1): 40–4. doi:10.4049/jimmunol.177.1.40. PMID 16785496. S2CID 922578.
Krambeck AE, Thompson RH, Dong H, Lohse CM, Park ES, Kuntz SM, Leibovich BC, Blute ML, Cheville JC, Kwon ED (July 2006). "B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival". Proceedings of the National Academy of Sciences of the United States of America. 103 (27): 10391–6. Bibcode:2006PNAS..10310391K. doi:10.1073/pnas.0600937103. PMC 1502468. PMID 16798883.
Chen Y, Yang C, Xie Z, Zou L, Ruan Z, Zhang X, Tang Y, Fei L, Jia Z, Wu Y (December 2006). "Expression of the novel co-stimulatory molecule B7-H4 by renal tubular epithelial cells". Kidney International. 70 (12): 2092–9. doi:10.1038/sj.ki.5001867. PMID 17051145.
Simon I, Katsaros D, Rigault de la Longrais I, Massobrio M, Scorilas A, Kim NW, Sarno MJ, Wolfert RL, Diamandis EP (August 2007). "B7-H4 is over-expressed in early-stage ovarian cancer and is independent of CA125 expression". Gynecologic Oncology. 106 (2): 334–41. doi:10.1016/j.ygyno.2007.03.035. PMID 17498784.
Miyatake T, Tringler B, Liu W, Liu SH, Papkoff J, Enomoto T, Torkko KC, Dehn DL, Swisher A, Shroyer KR (July 2007). "B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration". Gynecologic Oncology. 106 (1): 119–27. doi:10.1016/j.ygyno.2007.03.039. PMID 17509674.

인간 염색체 1번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000134258 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000051076 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12818165-5] Sica GL, Choi IH, Zhu G, Tamada K, Wang SD, Tamura H, Chapoval AI, Flies DB, Bajorath J, Chen L (June 2003). "B7-H4, a molecule of the B7 family, negatively regulates T cell immunity". Immunity. 18 (6): 849–61. doi:10.1016/S1074-7613(03)00152-3. PMID 12818165.

[pmid12818166-6] Prasad DV, Richards S, Mai XM, Dong C (June 2003). "B7S1, a novel B7 family member that negatively regulates T cell activation". Immunity. 18 (6): 863–73. doi:10.1016/S1074-7613(03)00147-X. PMID 12818166.

[entrez-7] "Entrez Gene: VTCN1 V-set domain containing T cell activation inhibitor 1".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

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VTCN1

네임스페이스

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목차

기능.

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레퍼런스

추가 정보

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VTCN1

기능.

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레퍼런스

추가 정보

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