주요 금고단백질

MVP
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1년 7개월
식별자
에일리어스	MVP, LRP, 볼트1, 주요 볼트 단백질
외부 ID	OMIM: 605088 MGI: 1925638 HomoloGene: 3752 GeneCard: MVP
유전자 위치(인간)
크르.	16번 염색체(인간)
끝.	29,848,039 bp
유전자 위치(마우스)
크르.	7번 염색체(쥐)
끝.	126,613,793 bp
RNA발현패턴
	상단 표시 위치:
	우부신; ; 좌부신; ; 좌폐 상엽; ; 자궁내막간질세포; ; 담낭; ; 직장; ; 단구; ; 오른쪽 폐; ; 위체; ; 위점막;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	단백질인산가수분해효소결합; GO:0001948 단백질 결합; 단백질인산화효소결합; 동일단백질결합;
셀룰러 컴포넌트	세포질; 세포질핵주위영역; 핵공; 세포외 엑소좀; 세포골격; 막; 핵; 세포외 영역; 세포; 분비성 과립내강; 피콜린1이 풍부한 과립 루멘;
생물학적 과정	단백질 수송; mRNA 트랜스포트; 단백질티로신인산화효소활성음성조절; ERBB 시그널링 패스; 시그널링의 네거티브 조절; 단백질 자기인산화 음성 조절; 호중구 탈과립; 운송;
	출처:아미고 / QuickGO
맞춤법
	9961
	78388
	ENSG000013364
	ENSMUSG000030681
	Q14764
	Q9EQK5
	NM_017458; NM_001293204; NM_001293205; NM_005115
	NM_080638
	NP_001280133; NP_001280134; NP_005106; NP_059447; NP_001280134.1
	NP_542369
	위키데이터
인간 보기/편집	마우스 표시/편집

주요 금고 단백질은 인간의 MVP ^[5]^[6]유전자에 의해 암호화되는 단백질이다. 78개의 복사가 금고라고 불리는 큰 칸에 모여있다.

기능.

이 유전자는 폐감염 내성 관련 단백질인 주요 볼트 단백질을 암호화한다.볼트는 핵세포질 운반에 관여할 수 있는 다중 서브유닛 구조이다.이 단백질은 아마도 운반 과정을 통해 약물의 내성을 매개합니다.그것은 정상 조직에 널리 분포하고 다제내성 암세포에서 과다 발현된다.단백질 과잉발현은 잠재적으로 임상 약물 내성의 유용한 지표이다.이 유전자는 두 개의 대체 엑손 2 서열을 사용하여 두 개의 전사를 생성하지만, 열린 판독 프레임은 두 ^[6]전사에서 동일합니다.

상호 작용

주요 볼트 단백질은 에스트로겐 수용체 알파,^[7] PTEN^[8] 및 ^[9]^[10]PARP4와 상호작용하는 것으로 나타났다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG000013364 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000030681 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Scheffer GL, Wijngaard PL, Flens MJ, Izquierdo MA, Slovak ML, Pinedo HM, Meijer CJ, Clevers HC, Scheper RJ (Jun 1995). "The drug resistance-related protein LRP is the human major vault protein". Nature Medicine. 1 (6): 578–82. doi:10.1038/nm0695-578. hdl:20.500.11755/c49e6086-ede3-4b91-ac6e-4ab9158c6cac. PMID 7585126. S2CID 29771830.
^ ^a ^b "Entrez Gene: MVP major vault protein".
^ Abbondanza C, Rossi V, Roscigno A, Gallo L, Belsito A, Piluso G, Medici N, Nigro V, Molinari AM, Moncharmont B, Puca GA (Jun 1998). "Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell". The Journal of Cell Biology. 141 (6): 1301–10. doi:10.1083/jcb.141.6.1301. PMC 2132791. PMID 9628887.
^ Yu Z, Fotouhi-Ardakani N, Wu L, Maoui M, Wang S, Banville D, Shen SH (Oct 2002). "PTEN associates with the vault particles in HeLa cells". The Journal of Biological Chemistry. 277 (43): 40247–52. doi:10.1074/jbc.M207608200. PMID 12177006.
^ van Zon A, Mossink MH, Schoester M, Scheffer GL, Scheper RJ, Sonneveld P, Wiemer EA (Mar 2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochemical and Biophysical Research Communications. 291 (3): 535–41. doi:10.1006/bbrc.2002.6472. PMID 11855821.
^ Kickhoefer VA, Siva AC, Kedersha NL, Inman EM, Ruland C, Streuli M, Rome LH (Sep 1999). "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase". The Journal of Cell Biology. 146 (5): 917–28. doi:10.1083/jcb.146.5.917. PMC 2169495. PMID 10477748.

추가 정보

Izquierdo MA, Scheffer GL, Flens MJ, Schroeijers AB, van der Valk P, Scheper RJ (Jun 1996). "Major vault protein LRP-related multidrug resistance". European Journal of Cancer. 32A (6): 979–84. doi:10.1016/0959-8049(96)00053-6. PMID 8763338.
Slovak ML, Ho JP, Cole SP, Deeley RG, Greenberger L, de Vries EG, Broxterman HJ, Scheffer GL, Scheper RJ (Oct 1995). "The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification". Cancer Research. 55 (19): 4214–9. PMID 7671223.
Izquierdo MA, Scheffer GL, Flens MJ, Giaccone G, Broxterman HJ, Meijer CJ, van der Valk P, Scheper RJ (Mar 1996). "Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors". The American Journal of Pathology. 148 (3): 877–87. PMC 1861735. PMID 8774142.
Dingemans AM, van Ark-Otte J, van der Valk P, Apolinario RM, Scheper RJ, Postmus PE, Giaccone G (Aug 1996). "Expression of the human major vault protein LRP in human lung cancer samples and normal lung tissues". Annals of Oncology. 7 (6): 625–30. doi:10.1093/oxfordjournals.annonc.a010681. PMID 8879378.
Sugawara I, Akiyama S, Scheper RJ, Itoyama S (Jan 1997). "Lung resistance protein (LRP) expression in human normal tissues in comparison with that of MDR1 and MRP". Cancer Letters. 112 (1): 23–31. doi:10.1016/S0304-3835(96)04542-9. PMID 9029166.
Abbondanza C, Rossi V, Roscigno A, Gallo L, Belsito A, Piluso G, Medici N, Nigro V, Molinari AM, Moncharmont B, Puca GA (Jun 1998). "Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell". The Journal of Cell Biology. 141 (6): 1301–10. doi:10.1083/jcb.141.6.1301. PMC 2132791. PMID 9628887.
Ikeda K, Oka M, Yamada Y, Soda H, Fukuda M, Kinoshita A, Tsukamoto K, Noguchi Y, Isomoto H, Takeshima F, Murase K, Kamihira S, Tomonaga M, Kohno S (Aug 1999). "Adult T-cell leukemia cells over-express the multidrug-resistance-protein (MRP) and lung-resistance-protein (LRP) genes". International Journal of Cancer. 82 (4): 599–604. doi:10.1002/(SICI)1097-0215(19990812)82:4<599::AID-IJC21>3.0.CO;2-R. PMID 10404077.
Rimsza LM, Campbell K, Dalton WS, Salmon S, Willcox G, Grogan TM (Jul 1999). "The major vault protein (MVP), a new multidrug resistance associated protein, is frequently expressed in multiple myeloma". Leukemia & Lymphoma. 34 (3–4): 315–24. doi:10.3109/10428199909050956. PMID 10439368.
Kickhoefer VA, Siva AC, Kedersha NL, Inman EM, Ruland C, Streuli M, Rome LH (Sep 1999). "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase". The Journal of Cell Biology. 146 (5): 917–28. doi:10.1083/jcb.146.5.917. PMC 2169495. PMID 10477748.
Kickhoefer VA, Stephen AG, Harrington L, Robinson MO, Rome LH (Nov 1999). "Vaults and telomerase share a common subunit, TEP1". The Journal of Biological Chemistry. 274 (46): 32712–7. doi:10.1074/jbc.274.46.32712. PMID 10551828.
Lange C, Walther W, Schwabe H, Stein U (Nov 2000). "Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter". Biochemical and Biophysical Research Communications. 278 (1): 125–33. doi:10.1006/bbrc.2000.3782. PMID 11071864.
Holzmann K, Ambrosch I, Elbling L, Micksche M, Berger W (Apr 2001). "A small upstream open reading frame causes inhibition of human major vault protein expression from a ubiquitous mRNA splice variant". FEBS Letters. 494 (1–2): 99–104. doi:10.1016/S0014-5793(01)02318-3. PMID 11297743. S2CID 9235641.
van Zon A, Mossink MH, Schoester M, Scheffer GL, Scheper RJ, Sonneveld P, Wiemer EA (Mar 2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochemical and Biophysical Research Communications. 291 (3): 535–41. doi:10.1006/bbrc.2002.6472. PMID 11855821.
Sakaki Y, Terashi K, Yamaguchi A, Kawamata N, Tokito Y, Mori H, Umehara M, Yoshiyama T, Ohtsubo H, Arimura K, Arima N, Tei C (Apr 2002). "Human T-cell lymphotropic virus type I Tax activates lung resistance-related protein expression in leukemic clones established from an adult T-cell leukemia patient". Experimental Hematology. 30 (4): 340–5. doi:10.1016/S0301-472X(02)00775-0. PMID 11937269.
Zhao Y, Yu L, Wang Q, Lou F, Pu J (Mar 2002). "[The relationship between expression of lung resistance-related protein gene or multidrug resistance-associated protein gene and prognosis in newly diagnosed acute leukemia]". Zhonghua Nei Ke Za Zhi. 41 (3): 183–5. PMID 11940320.
Scheffer GL, Pijnenborg AC, Smit EF, Müller M, Postma DS, Timens W, van der Valk P, de Vries EG, Scheper RJ (May 2002). "Multidrug resistance related molecules in human and murine lung". Journal of Clinical Pathology. 55 (5): 332–9. doi:10.1136/jcp.55.5.332. PMC 1769658. PMID 11986335.
van den Heuvel-Eibrink MM, Wiemer EA, Prins A, Meijerink JP, Vossebeld PJ, van der Holt B, Pieters R, Sonneveld P (May 2002). "Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML)". Leukemia. 16 (5): 833–9. doi:10.1038/sj.leu.2402496. PMID 11986944.
Yu Z, Fotouhi-Ardakani N, Wu L, Maoui M, Wang S, Banville D, Shen SH (Oct 2002). "PTEN associates with the vault particles in HeLa cells". The Journal of Biological Chemistry. 277 (43): 40247–52. doi:10.1074/jbc.M207608200. PMID 12177006.

인간 염색체 16번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG000013364 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000030681 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7585126-5] Scheffer GL, Wijngaard PL, Flens MJ, Izquierdo MA, Slovak ML, Pinedo HM, Meijer CJ, Clevers HC, Scheper RJ (Jun 1995). "The drug resistance-related protein LRP is the human major vault protein". Nature Medicine. 1 (6): 578–82. doi:10.1038/nm0695-578. hdl:20.500.11755/c49e6086-ede3-4b91-ac6e-4ab9158c6cac. PMID 7585126. S2CID 29771830.

[entrez-6] "Entrez Gene: MVP major vault protein".

[pmid9628887-7] Abbondanza C, Rossi V, Roscigno A, Gallo L, Belsito A, Piluso G, Medici N, Nigro V, Molinari AM, Moncharmont B, Puca GA (Jun 1998). "Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell". The Journal of Cell Biology. 141 (6): 1301–10. doi:10.1083/jcb.141.6.1301. PMC 2132791. PMID 9628887.

[pmid12177006-8] Yu Z, Fotouhi-Ardakani N, Wu L, Maoui M, Wang S, Banville D, Shen SH (Oct 2002). "PTEN associates with the vault particles in HeLa cells". The Journal of Biological Chemistry. 277 (43): 40247–52. doi:10.1074/jbc.M207608200. PMID 12177006.

[pmid11855821-9] van Zon A, Mossink MH, Schoester M, Scheffer GL, Scheper RJ, Sonneveld P, Wiemer EA (Mar 2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochemical and Biophysical Research Communications. 291 (3): 535–41. doi:10.1006/bbrc.2002.6472. PMID 11855821.

[pmid10477748-10] Kickhoefer VA, Siva AC, Kedersha NL, Inman EM, Ruland C, Streuli M, Rome LH (Sep 1999). "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase". The Journal of Cell Biology. 146 (5): 917–28. doi:10.1083/jcb.146.5.917. PMC 2169495. PMID 10477748.

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v t RNA결합단백질 : 리보핵단백질
snRNP	A A1 B B2 C D1 D2 D3 E F G N 70K/U1 스플라이소좀RNA SNRNP200
hnRNP	A0 C L R
기타 문자 변환	텔로머라아제
번역.	리보솜
볼트리보핵단백질 입자들.	주요 금고단백질
다른.	신호 인식 입자

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