SNRPB
SNRPB| SNRPB | |||||||||||||||||||||||||
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| 식별자 | |||||||||||||||||||||||||
| 에일리어스 | SNRPB, COD, SNRPB1, Sm-B/B', SmB/B', SmB/SmB', snRNP-B, CCMS, 소핵리보핵단백질폴리펩티드B 및 B1 | ||||||||||||||||||||||||
| 외부 ID | OMIM : 182282 MGI : 98342 HomoloGene : 134543 GenCard : SNRPB | ||||||||||||||||||||||||
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| 종. | 인간 | 마우스 | |||||||||||||||||||||||
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| 앙상블 | |||||||||||||||||||||||||
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| RefSeq(mRNA) | |||||||||||||||||||||||||
| RefSeq(단백질) | |||||||||||||||||||||||||
| 장소(UCSC) | Chr 20: 2.46 ~2.47 Mb | Chr 2: 130.01 ~130.02 Mb | |||||||||||||||||||||||
| PubMed 검색 | [3] | [4] | |||||||||||||||||||||||
| 위키데이터 | |||||||||||||||||||||||||
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소핵리보핵단백질 관련 단백질 B, B'는 SNRPB [5][6]유전자에 의해 인체 내에서 코드되는 단백질이다.
기능.
이 유전자에 의해 암호화된 단백질은 U1, U2, U4/U6, 그리고 U5 작은 리보핵단백질 입자 사이에서 공통적으로 발견되는 여러 핵단백질 중 하나이다.이러한 snRNP는 pre-mRNA 스플라이싱에 관여하며, 부호화된 단백질은 pre-mRNA 스플라이싱 또는 snRNP 구조에도 역할을 할 수 있다.전신성 홍반성 낭창 환자의 자가항체는 암호화된 단백질의 에피토프를 자주 인식한다.이 [6]유전자에 대해 서로 다른 아이소폼(B와 B')을 코드하는 두 가지 전사 변형이 발견되었다.
상호 작용
SNRPB는 DDX20[7] 및 Coilin과 [8]상호 작용하는 것으로 나타났습니다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000125835 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000027404 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Griffith AJ, Schmauss C, Craft J (July 1992). "The murine gene encoding the highly conserved Sm B protein contains a nonfunctional alternative 3' splice site". Gene. 114 (2): 195–201. doi:10.1016/0378-1119(92)90574-9. PMID 1376292.
- ^ a b "Entrez Gene: SNRPB small nuclear ribonucleoprotein polypeptides B and B1".
- ^ Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (Dec 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
- ^ Hebert MD, Szymczyk PW, Shpargel KB, Matera AG (October 2001). "Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein". Genes Dev. 15 (20): 2720–9. doi:10.1101/gad.908401. PMC 312817. PMID 11641277.
추가 정보
- Will CL, Lührmann R (2001). "Spliceosomal UsnRNP biogenesis, structure and function". Curr. Opin. Cell Biol. 13 (3): 290–301. doi:10.1016/S0955-0674(00)00211-8. hdl:11858/00-001M-0000-0012-F770-0. PMID 11343899.
- Schmauss C, Lerner MR (1990). "The closely related small nuclear ribonucleoprotein polypeptides N and B/B' are distinguishable by antibodies as well as by differences in their mRNAs and gene structures". J. Biol. Chem. 265 (18): 10733–9. doi:10.1016/S0021-9258(18)87008-9. PMID 1693924.
- Elkon KB, Hines JJ, Chu JL, Parnassa A (1990). "Epitope mapping of recombinant HeLa SmB and B' peptides obtained by the polymerase chain reaction". J. Immunol. 145 (2): 636–43. PMID 1694885.
- Chu JL, Elkon KB (1991). "The small nuclear ribonucleoproteins, SmB and B', are products of a single gene". Gene. 97 (2): 311–2. doi:10.1016/0378-1119(91)90069-N. PMID 1825643.
- Sharpe NG, Williams DG, Latchman DS (1990). "Regulated expression of the small nuclear ribonucleoprotein particle protein SmN in embryonic stem cell differentiation". Mol. Cell. Biol. 10 (12): 6817–20. doi:10.1128/mcb.10.12.6817. PMC 362965. PMID 2174118.
- Schmauss C, McAllister G, Ohosone Y, Hardin JA, Lerner MR (1989). "A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'". Nucleic Acids Res. 17 (4): 1733–43. doi:10.1093/nar/17.4.1733. PMC 331831. PMID 2522186.
- Feeney RJ, Sauterer RA, Feeney JL, Zieve GW (1989). "Cytoplasmic assembly and nuclear accumulation of mature small nuclear ribonucleoprotein particles". J. Biol. Chem. 264 (10): 5776–83. doi:10.1016/S0021-9258(18)83617-1. PMID 2522439.
- Ohosone Y, Mimori T, Griffith A, Akizuki M, Homma M, Craft J, Hardin JA (1989). "Molecular cloning of cDNA encoding Sm autoantigen: derivation of a cDNA for a B polypeptide of the U series of small nuclear ribonucleoprotein particles". Proc. Natl. Acad. Sci. U.S.A. 86 (11): 4249–53. Bibcode:1989PNAS...86.4249O. doi:10.1073/pnas.86.11.4249. PMC 287428. PMID 2524838.
- van Dam A, Winkel I, Zijlstra-Baalbergen J, Smeenk R, Cuypers HT (1989). "Cloned human snRNP proteins B and B' differ only in their carboxy-terminal part". EMBO J. 8 (12): 3853–60. doi:10.1002/j.1460-2075.1989.tb08563.x. PMC 402073. PMID 2531083.
- Huntriss JD, Latchman DS, Williams DG (1993). "Lupus autoantibodies discriminate between the highly homologous Sm polypeptides B/B' and SmN by binding an epitope restricted to B/B'". Clin. Exp. Immunol. 92 (2): 263–7. doi:10.1111/j.1365-2249.1993.tb03390.x. PMC 1554819. PMID 7683587.
- Gerrelli D, Grimaldi K, Horn D, Mahadeva U, Sharpe N, Latchman DS (1993). "The cardiac form of the tissue-specific SmN protein is identical to the brain and embryonic forms of the protein". J. Mol. Cell. Cardiol. 25 (3): 321–9. doi:10.1006/jmcc.1993.1038. PMID 8510173.
- Simons A, Melamed-Bessudo C, Wolkowicz R, Sperling J, Sperling R, Eisenbach L, Rotter V (1997). "PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb". Oncogene. 14 (2): 145–55. doi:10.1038/sj.onc.1200825. PMID 9010216.
- Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013–21. doi:10.1016/S0092-8674(00)80367-0. PMID 9323129. S2CID 10855404.
- Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1997). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.
- Bedford MT, Reed R, Leder P (1998). "WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10602–7. Bibcode:1998PNAS...9510602B. doi:10.1073/pnas.95.18.10602. PMC 27941. PMID 9724750.
- Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K (1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell. 96 (3): 375–87. doi:10.1016/S0092-8674(00)80550-4. PMID 10025403. S2CID 17379935.
- Gray TA, Smithwick MJ, Schaldach MA, Martone DL, Graves JA, McCarrey JR, Nicholls RD (1999). "Concerted regulation and molecular evolution of the duplicated SNRPB'/B and SNRPN loci". Nucleic Acids Res. 27 (23): 4577–84. doi:10.1093/nar/27.23.4577. PMC 148745. PMID 10556313.
- Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
- Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli". J. Cell Biol. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312. PMID 10725331.
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