LY-487,379

LY-487,379
LY-487,379
LY-487,3793Dan.svg
임상자료
ATC 코드
  • 없는
식별자
  • N-(4-(2-메톡시페녹시)페닐)-N-(2,2-트리플루오로에틸설폰)피리드- 3-ylmethylamine
CAS 번호
펍켐 CID
IUPHAR/BPS
켐스파이더
켐벨
CompTox 대시보드 (EPA)
화학 및 물리적 데이터
공식C21H19F3N2O4S
어금질량452.45 g·190−1
3D 모델(JSmol)
  • c3ncc3CN(S(=O)CC(F)F)c2cc(cc2)Ooc1ccc1OC
  • InChI=1S/C21H19F3N2O4S/c1-29-19-6-2-3-7-20(19)30-18-10-8-17(9-11-18)26(14-16-5-4-12-25-13-16)31(27,28)15-21(22,23)24/h2-13H,14-15H2,1H3 ☒N
  • 키:AMMACYDZFBMGR-UHFFFAOYSA-N ☒N
☒NcheckY (이게 뭐야?) (iii)

LY-48만7379는 메타보틱 글루탐산염 수용체 그룹 II 아형 mGluR의2 선택적 양성 알로스테리 모듈레이터 역할을 하는 과학 연구에 사용되는 약물이다.[1]이 수용체 아형의 구조와 기능을 연구하는 데 사용되며,[2][3] 다양한 다른2/3 mGluR 작용제 및 양성 조절제와 함께 LY-48만7379가 항정신병·불안제 약물로 조사되고 있다.[4][5][6][7][8]

참고 항목

참조

  1. ^ Johnson MP, Baez M, Jagdmann GE, Britton TC, Large TH, Callagaro DO, et al. (July 2003). "Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine". Journal of Medicinal Chemistry. 46 (15): 3189–92. doi:10.1021/jm034015u. PMID 12852748.
  2. ^ Schaffhauser H, Rowe BA, Morales S, Chavez-Noriega LE, Yin R, Jachec C, et al. (October 2003). "Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2". Molecular Pharmacology. 64 (4): 798–810. doi:10.1124/mol.64.4.798. PMID 14500736.
  3. ^ Poisik O, Raju DV, Verreault M, Rodriguez A, Abeniyi OA, Conn PJ, Smith Y (2005). "Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus". Neuropharmacology. 49 Suppl 1: 57–69. doi:10.1016/j.neuropharm.2005.03.006. PMID 15993439. S2CID 21881395.
  4. ^ Galici R, Echemendia NG, Rodriguez AL, Conn PJ (December 2005). "A selective allosteric potentiator of metabotropic glutamate (mGlu) 2 receptors has effects similar to an orthosteric mGlu2/3 receptor agonist in mouse models predictive of antipsychotic activity" (PDF). The Journal of Pharmacology and Experimental Therapeutics. 315 (3): 1181–1187. doi:10.1124/jpet.105.091074. PMID 16123306. S2CID 9159875. Archived from the original (PDF) on 2019-02-21.
  5. ^ Marino MJ, Conn PJ (February 2006). "Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors". Current Opinion in Pharmacology. 6 (1): 98–102. doi:10.1016/j.coph.2005.09.006. PMID 16368268.
  6. ^ Harich S, Gross G, Bespalov A (July 2007). "Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatment". Psychopharmacology. 192 (4): 511–9. doi:10.1007/s00213-007-0742-y. PMID 17318501. S2CID 7551116.
  7. ^ Conn PJ, Jones CK (January 2009). "Promise of mGluR2/3 activators in psychiatry". Neuropsychopharmacology. 34 (1): 248–9. doi:10.1038/npp.2008.156. PMC 2907744. PMID 19079073.
  8. ^ Hermes ML, Renaud LP (March 2011). "Postsynaptic and presynaptic group II metabotropic glutamate receptor activation reduces neuronal excitability in rat midline paraventricular thalamic nucleus" (PDF). The Journal of Pharmacology and Experimental Therapeutics. 336 (3): 840–9. doi:10.1124/jpet.110.176149. PMID 21139059. S2CID 25111011. Archived from the original (PDF) on 2019-02-22.
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신경계통에 관한 이 약물 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.