CPCCOEt

CPCCOEt
CPCCOEt
CPCCOEt.svg
식별자
  • (----에틸(7E)-7-히드로시미노-1,7a-디히드로시클로프로파[b]크롬-1a-카르복실산염
CAS 번호
펍켐 CID
IUPHAR/BPS
켐벨
화학 및 물리적 데이터
공식C13H13NO4
어금질량247.250 g·190−1
3D 모델(JSmol)
  • CCOC(=O)C23Cccc1\C(=N\O)\C2C3
☒NcheckY (이게 뭐야?) (iii)

CPCCOEt는 과학 연구에 사용되는 약물로, 중간 결합 친화력만 있을 뿐 선택성이 높은 메타보틱성 글루타민 수용체 서브타입 mGluR에서1 비경쟁적 길항제 역할을 한다.[1][2]기억력, 중독에 미치는 영향 등 동물에서의 행동효과 연구를 비롯해 mGluR1 수용체 기능에 대한 기초연구에 주로 사용된다.[3][4][5][6]

참고 항목

참조

  1. ^ Litschig S, Gasparini F, Rueegg D, Stoehr N, Flor PJ, Vranesic I, Prézeau L, Pin JP, Thomsen C, Kuhn R (March 1999). "CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding". Molecular Pharmacology. 55 (3): 453–61. PMID 10051528.
  2. ^ Ott D, Floersheim P, Inderbitzin W, Stoehr N, Francotte E, Lecis G, Richert P, Rihs G, Flor PJ, Kuhn R, Gasparini F (November 2000). "Chiral resolution, pharmacological characterization, and receptor docking of the noncompetitive mGlu1 receptor antagonist (+/-)-2-hydroxyimino- 1a, 2-dihydro-1H-7-oxacyclopropa[b]naphthalene-7a-carboxylic acid ethyl ester". Journal of Medicinal Chemistry. 43 (23): 4428–36. doi:10.1021/jm0009944. PMID 11087567.
  3. ^ Fukunaga I, Yeo CH, Batchelor AM (February 2007). "The mGlu1 antagonist CPCCOEt enhances the climbing fibre response in Purkinje neurones independently of glutamate receptors". Neuropharmacology. 52 (2): 450–8. doi:10.1016/j.neuropharm.2006.08.014. PMID 17045308. S2CID 40361285.
  4. ^ Sugiyama Y, Kawaguchi SY, Hirano T (February 2008). "mGluR1-mediated facilitation of long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron". The European Journal of Neuroscience. 27 (4): 884–96. doi:10.1111/j.1460-9568.2008.06063.x. PMID 18279362. S2CID 25581416.
  5. ^ Lominac KD, Kapasova Z, Hannun RA, Patterson C, Middaugh LD, Szumlinski KK (November 2006). "Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties". Drug and Alcohol Dependence. 85 (2): 142–56. doi:10.1016/j.drugalcdep.2006.04.003. PMID 16697125.
  6. ^ Kim J, Lee S, Park H, Song B, Hong I, Geum D, Shin K, Choi S (March 2007). "Blockade of amygdala metabotropic glutamate receptor subtype 1 impairs fear extinction". Biochemical and Biophysical Research Communications. 355 (1): 188–93. doi:10.1016/j.bbrc.2007.01.125. PMID 17292864.


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신경계통에 관한 이 약물 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.