EGLU

EGLU
EGLU
(2S)-α-ethylglutamic acid.svg
식별자
  • (2S)-2-아미노-2-에틸펜탄디오산
CAS 번호
PubChem CID
IUPHAR/BPS
켐스파이더
CompTox 대시보드 (EPA )
화학 및 물리 데이터
공식C7H13NO4
몰 질량175.184 g/140−1
3D 모델(JSmol)
  • O=C(O)CC[C@](N)(C(=O)O)참조
  • InChI=1S/C7H13NO4/c1-2-7(8,6(11)12)4-3-5(9)10/h2-4,8H2,1H3,(H,9,10)(H,11,12)/t7-m0/1s1 ☒N
  • 키: QFYBYZLHPIALCZ-ZETCQYMHSA-N ☒N
☒NcheckY (이게 뭐죠?) (표준)

EGLU((2S)-α-에틸글루탐산)는 신경과학 연구에 사용되는 약물이다.이는 II족 메타트로픽 글루탐산 수용체(mGluR2/3)에 대한 선택적 길항제 역할을 하는 것으로 발견된 첫 번째 화합물 중 하나였으며, 따라서 이 수용체 [1][2][3][4][5][6][7]서브패밀리의 특성화 및 연구에 유용했다.

레퍼런스

  1. ^ Jane DE, Thomas NK, Tse HW, Watkins JC (1996). "Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord". Neuropharmacology. 35 (8): 1029–35. doi:10.1016/S0028-3908(96)00048-2. PMID 9121605. S2CID 6238847.
  2. ^ Huang L, Rowan MJ, Anwyl R (February 1999). "Induction of long-lasting depression by (+)-alpha-methyl-4-carboxyphenylglycine and other group II mGlu receptor ligands in the dentate gyrus of the hippocampus in vitro". European Journal of Pharmacology. 366 (2–3): 151–8. doi:10.1016/S0014-2999(98)00918-2. PMID 10082195.
  3. ^ Palazzo E, Marabese I, de Novellis V, Oliva P, Rossi F, Berrino L, et al. (March 2001). "Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception". Neuropharmacology. 40 (3): 319–26. doi:10.1016/S0028-3908(00)00160-X. PMID 11166324. S2CID 41189905.
  4. ^ Iserhot C, Gebhardt C, Schmitz D, Heinemann U (November 2004). "Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat". Brain Research. 1027 (1–2): 151–60. doi:10.1016/j.brainres.2004.08.052. PMID 15494166. S2CID 33373525.
  5. ^ Cahusac PM, Wan H (April 2007). "Group II metabotropic glutamate receptors reduce excitatory but not inhibitory neurotransmission in rat barrel cortex in vivo". Neuroscience. 146 (1): 202–12. doi:10.1016/j.neuroscience.2007.01.049. PMID 17346894. S2CID 37975672.
  6. ^ Kim WY, Vezina P, Kim JH (August 2008). "Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment". Behavioural Brain Research. 191 (1): 62–6. doi:10.1016/j.bbr.2008.03.010. PMID 18433894. S2CID 24250755.
  7. ^ Altinbilek B, Manahan-Vaughan D (January 2009). "A specific role for group II metabotropic glutamate receptors in hippocampal long-term depression and spatial memory". Neuroscience. 158 (1): 149–58. doi:10.1016/j.neuroscience.2008.07.045. PMID 18722513. S2CID 40251815.
Stub icon

신경계에 관한 이 약물 기사는 엉터리이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.