PCCG-4

PCCG-4
PCCG-4
PCCG-4 structure.png
식별자
  • (2S,1'S,2'S,3'R)-2-(2'카르복시-3'-페닐시클로프로필)글리신
PubChem CID
IUPHAR/BPS
켐스파이더
첸블
화학 및 물리 데이터
공식C12H13NO4
몰 질량235.239g/120−1
3D 모델(JSmol)
  • C1=CC=C(C=C1)[C@H]2[C@H]([C@H]2C(=O)[C@H](C(=O)O)[C(=O)O)]n
  • InChI=1S/C12H13NO4/c13-10(12)8-7(9)11(14)15)6-4-2-1-3-5-6/h1-5,7-10H2,(H,14,15)(13,177t)
  • 키: IFLWVSRWAIVQF-KATARQTJSA-N checkY
(표준)

PCCG-4는 mGluR2 및 mGluR3 반응을 서로 구별하기에 충분하지 않지만 mGluR에2 대한 약간의 선택성을 가진 II족 메타방성 글루타메이트 수용체(mGluR2/3)에 대한 선택적 길항제 역할을 하는 연구 약물이다.이것은 II족 메타트로픽 글루탐산 [1][2][3][4][5]수용체의 기능에 대한 연구에 사용된다.

레퍼런스

  1. ^ Pellicciari R, Marinozzi M, Natalini B, Costantino G, Luneia R, Giorgi G, Moroni F, Thomsen C (May 1996). "Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist". Journal of Medicinal Chemistry. 39 (11): 2259–69. doi:10.1021/jm960059+. PMID 8667369.
  2. ^ Thomsen C, Bruno V, Nicoletti F, Marinozzi M, Pellicciari R (July 1996). "(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors". Molecular Pharmacology. 50 (1): 6–9. PMID 8700119.
  3. ^ Cozzi A, Attucci S, Peruginelli F, Marinozzi M, Luneia R, Pellicciari R, Moroni F (July 1997). "Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: in vivo studies with (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a new potent and selective antagonist". The European Journal of Neuroscience. 9 (7): 1350–5. doi:10.1111/j.1460-9568.1997.tb01489.x. PMID 9240392. S2CID 39993000.
  4. ^ Ciccarelli R, Di Iorio P, Bruno V, Battaglia G, D'Alimonte I, D'Onofrio M, Nicoletti F, Caciagli F (September 1999). "Activation of A(1) adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100beta protein from cultured astrocytes". Glia. 27 (3): 275–81. doi:10.1002/(SICI)1098-1136(199909)27:3<275::AID-GLIA9>3.0.CO;2-0. PMID 10457374.
  5. ^ Vetter P, Garthwaite J, Batchelor AM (June 1999). "Regulation of synaptic transmission in the mossy fibre-granule cell pathway of rat cerebellum by metabotropic glutamate receptors". Neuropharmacology. 38 (6): 805–15. doi:10.1016/S0028-3908(99)00003-9. PMID 10465684. S2CID 10116115.


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신경계에 관한 이 약물 기사는 엉터리이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.