CDPPB

CDPPB
CDPPB
CDPPB Structure.svg
식별자
  • 3-시아노-N-(1,3-디페닐-1H-피라졸-5-yl)벤자미드
CAS 번호
펍켐 CID
IUPHAR/BPS
켐스파이더
CompTox 대시보드 (EPA)
ECHA InfoCard100.222.673 Edit this at Wikidata
화학 및 물리적 데이터
공식C23H18N4O
어금질량366.424 g·190−1
3D 모델(JSmol)
  • c3ccc3-n1nc(-c4ccc4)cc1NC(=O)c(c2)ccc2C#n
  • InChI=1S/C23H16N4O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20/h1-15H,(H,25,28) ☒N
  • 키:BKUIZWILNWHHD-UHFFFAOYSA-N ☒N
☒NcheckY (이게 뭐야?) (iii)

CDPPB는 메타보틱 글루탐산 수용체 하위형 mGluR에5 선택적으로 양성합성 모듈레이터 역할을 하는 과학 연구에 사용되는 약물이다.[1][2][3]동물 모델에서 항정신병 효과가 있으며,[4][5] mGluR5 조절기는 조현병 치료제뿐 아니라 다른 용도의 잠재적 약물로도 조사 중이다.[6][7]

참조

  1. ^ Lindsley CW, Wisnoski DD, Leister WH, O'brien JA, Lemaire W, Williams DL, Burno M, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Duggan ME, Hartman GD, Conn PJ, Huff JR (November 2004). "Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo". Journal of Medicinal Chemistry. 47 (24): 5825–8. doi:10.1021/jm049400d. PMID 15537338.
  2. ^ de Paulis T, Hemstapat K, Chen Y, Zhang Y, Saleh S, Alagille D, Baldwin RM, Tamagnan GD, Conn PJ (June 2006). "Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes". Journal of Medicinal Chemistry. 49 (11): 3332–44. doi:10.1021/jm051252j. PMID 16722652.
  3. ^ Chen Y, Nong Y, Goudet C, Hemstapat K, de Paulis T, Pin JP, Conn PJ (May 2007). "Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses". Molecular Pharmacology. 71 (5): 1389–98. doi:10.1124/mol.106.032425. PMID 17303702.
  4. ^ Kinney GG, O'Brien JA, Lemaire W, Burno M, Bickel DJ, Clements MK, Chen TB, Wisnoski DD, Lindsley CW, Tiller PR, Smith S, Jacobson MA, Sur C, Duggan ME, Pettibone DJ, Conn PJ, Williams DL (April 2005). "A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models". The Journal of Pharmacology and Experimental Therapeutics. 313 (1): 199–206. doi:10.1124/jpet.104.079244. PMID 15608073.
  5. ^ Lindsley CW, Shipe WD, Wolkenberg SE, Theberge CR, Williams DL, Sur C, Kinney GG (2006). "Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia". Current Topics in Medicinal Chemistry. 6 (8): 771–85. doi:10.2174/156802606777057599. PMID 16719816.
  6. ^ Lecourtier L, Homayoun H, Tamagnan G, Moghaddam B (October 2007). "Positive allosteric modulation of metabotropic glutamate 5 (mGlu5) receptors reverses N-Methyl-D-aspartate antagonist-induced alteration of neuronal firing in prefrontal cortex". Biological Psychiatry. 62 (7): 739–46. doi:10.1016/j.biopsych.2006.12.003. PMC 2910402. PMID 17511968.
  7. ^ Gass JT, Olive MF (April 2009). "Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memory". Biological Psychiatry. 65 (8): 717–20. doi:10.1016/j.biopsych.2008.11.001. PMC 2870714. PMID 19100966.


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신경계통에 관한 이 약물 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.