5β-감소효소
5β-Reductase| Δ-3-옥소스테로이드4 5β-저감효소 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 식별자 | |||||||||
| EC 번호 | 1.3.1.3 | ||||||||
| CAS 번호. | 2604034 | ||||||||
| 데이터베이스 | |||||||||
| 인텐츠 | IntEnz 뷰 | ||||||||
| 브렌다 | 브렌다 입력 | ||||||||
| 엑스퍼시 | 나이스자이메 뷰 | ||||||||
| 케그 | KEG 입력 | ||||||||
| 메타사이크 | 대사통로 | ||||||||
| 프리암 | 프로필 | ||||||||
| PDB 구조 | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
5β-Reductase, or Δ4-3-oxosteroid 5β-reductase (EC 1.3.1.3, 3-oxo-Δ4-steroid 5β-reductase, androstenedione 5β-reductase, cholestenone 5β-reductase, cortisone 5β-reductase, cortisone Δ4-5β-reductase, steroid 5β-reductase, testosterone 5β-reductase, Δ4-3-ketosteroid 5β-reductase, Δ4-5β-reductase, Δ4-hydrogenase, 4,5β-dihydrocortisone:NADP+ Δ-oxidoreductase4, 3-oxo-5β-스테로이드:NADP+ Δ-oxidoreductase4)는 체계적 이름 5β-콜레스탄-3-1을 가진 효소다.NADP+ 4,5-산소 유도효소.[1][2][3][4][5][6][7][8][9]이 효소는 다음과 같은 화학 반응을 촉진한다.
- (1) 5β-콜레스트탄-3-1 + NADP+ 콜레스트-4-en-3-1 + NADPH+ + H
- (2) 17,21-dihydroxy-5β-pregnane-3,11,20-tione + NADP+ 코티손 + NADPH+ + H
인간 효소는 프로게스테론, 17α-히드로록시프로게스테론, 안드로스테리온에 효율적으로 작용하며, 테스토스테론은 5β 감소 대사물에 작용한다.알도스테론, 코르티코스테론, 코티솔에도 어느 정도 효과가 있다.
참고 항목
참조
- ^ Dorfman RI, Forchielli E (November 1956). "Separation of delta 4-5 alpha-hydrogenases from rat liver homogenates". The Journal of Biological Chemistry. 223 (1): 443–8. PMID 13376613.
- ^ Brown-Grant K, Forchielli E, Dorfman RI (May 1960). "The delta4-hydrogenases of guinea pig adrenal gland". The Journal of Biological Chemistry. 235: 1317–20. PMID 13805063.
- ^ Levy, H.R. & Talalay, P. (1957). "Enzymatic introduction of double bonds into steroid ring A". J. Am. Chem. Soc. 79 (10): 2658–2659. doi:10.1021/ja01567a089.
- ^ Tomkins GM (March 1957). "The enzymatic reduction of delta 4-3-ketosteroids". The Journal of Biological Chemistry. 225 (1): 13–24. PMID 13416214.
- ^ Sugimoto Y, Yoshida M, Tamaoki B (December 1990). "Purification of 5 beta-reductase from hepatic cytosol fraction of chicken". The Journal of Steroid Biochemistry and Molecular Biology. 37 (5): 717–24. doi:10.1016/0960-0760(90)90356-p. PMID 2278855. S2CID 54431282.
- ^ Furuebisu M, Deguchi S, Okuda K (March 1987). "Identification of cortisone 5 beta-reductase as delta 4-3-ketosteroid 5 beta-reductase". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 912 (1): 110–4. doi:10.1016/0167-4838(87)90253-6. PMID 3828348.
- ^ Okuda A, Okuda K (June 1984). "Purification and characterization of delta 4-3-ketosteroid 5 beta-reductase". The Journal of Biological Chemistry. 259 (12): 7519–24. PMID 6736016.
- ^ Charbonneau A, The VL (January 2001). "Genomic organization of a human 5beta-reductase and its pseudogene and substrate selectivity of the expressed enzyme". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1517 (2): 228–35. doi:10.1016/s0167-4781(00)00278-5. PMID 11342103.
- ^ Kondo KH, Kai MH, Setoguchi Y, Eggertsen G, Sjöblom P, Setoguchi T, Okuda KI, Björkhem I (January 1994). "Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme". European Journal of Biochemistry. 219 (1–2): 357–63. doi:10.1111/j.1432-1033.1994.tb19947.x. PMID 7508385.
외부 링크
- 델타4-3-옥소스테로이드+5베타-저감효소(MesH) 미국 국립의학도서관(MesH)
