N-myc 인터랙터

NMI
식별자
에일리어스	NMI, N-myc 및 STAT 인터랙터
외부 ID	OMIM: 603525 MGI: 1928368 HomoloGene: 3441 GeneCard: NMI
유전자 위치(인간)
크르.	2번 염색체(인간)
끝.	151,289,894 bp
유전자 위치(마우스)
크르.	2번 염색체(마우스)
끝.	51,863,506 bp
RNA발현패턴
	상단 표시 위치:
	단구; ; 결석골; ; 피; ; 골수; ; 안검결막; ; 두정 흉막; ; 생식 상피; ; 부록; ; 내장 흉막; ; 제주날 점막;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	GO:0001948 단백질 결합; GO:0001104 트랜스크립션코어레이터 액티비티; 동일단백질결합;
셀룰러 컴포넌트	세포질; 핵소체; 세포;
생물학적 과정	RNA중합효소II에 의한 전사; 인터페론산염신호경로; 핵산 촉진 전사 조절; 단백질 K48결합유비퀴티네이션의 양성조절; JAK-STAT를 통한 수용체 시그널링 경로; I형 간섭자 생성의 음성 조절; 염증 반응; 선천성 면역 반응의 음성 조절;
	출처:아미고 / QuickGO
맞춤법
	9111
	64685
	ENSG00000123609
	ENSMUSG000026946
	문제 13287
	O35309
	NM_004688
	NM_001141948; NM_001141949; NM_019401
	NP_004679
	NP_001135420; NP_001135421; NP_062274
	위키데이터
인간 보기/편집	마우스 표시/편집

N-myc-interactor는 N-myc 및 STAT interactor로도 알려져 있으며, NMI ^[5]^[6]^[7]유전자에 의해 사람에게서 암호화되는 단백질이다.

기능.

NMYC 인터랙터(NMI)는 NMYC 및 CMYC(종양 유전자 Myc 패밀리의 2개 멤버) 및 Zip, HLH 또는 HLH-Zip 모티브를 포함하는 기타 전사 인자와 상호 작용합니다.또한 NMI 단백질은 STAT2를 제외한 모든 STAT와 상호작용하며 사이토카인 IL-2 및 IFN-gamma에 반응하여 STAT 매개 전사를 증가시킨다.NMI mRNA는 뇌를 제외한 모든 인체 태아 및 성인 조직에서 발현 수준이 낮으며 암 세포주 골수성 ^[7]백혈병에서 발현 수준이 높다.

상호 작용

NMI(유전자)는 BRCA1,^[8] IFI35,^[9] Myc,^[8] STAT5A ^[6]및 TUBA3C와 ^[10]상호작용하는 것으로 나타났다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000123609 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000026946 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bao J, Zervos AS (Aug 1996). "Isolation and characterization of Nmi, a novel partner of Myc proteins". Oncogene. 12 (10): 2171–6. PMID 8668343.
^ ^a ^b Zhu M, John S, Berg M, Leonard WJ (Mar 1999). "Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling". Cell. 96 (1): 121–30. doi:10.1016/S0092-8674(00)80965-4. PMID 9989503. S2CID 14758136.
^ ^a ^b "Entrez Gene: NMI N-myc (and STAT) interactor".
^ ^a ^b Li H, Lee TH, Avraham H (June 2002). "A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer". J. Biol. Chem. 277 (23): 20965–73. doi:10.1074/jbc.M112231200. PMID 11916966.
^ Chen J, Shpall RL, Meyerdierks A, Hagemeier M, Böttger EC, Naumovski L (November 2000). "Interferon-inducible Myc/STAT-interacting protein Nmi associates with IFP 35 into a high molecular mass complex and inhibits proteasome-mediated degradation of IFP 35". J. Biol. Chem. 275 (46): 36278–84. doi:10.1074/jbc.M006975200. PMID 10950963.
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

추가 정보

Lebrun SJ, Shpall RL, Naumovski L (1998). "Interferon-induced upregulation and cytoplasmic localization of Myc-interacting protein Nmi". J. Interferon Cytokine Res. 18 (9): 767–71. doi:10.1089/jir.1998.18.767. PMID 9781816.
Lee ND, Chen J, Shpall RL, Naumovski L (1999). "Subcellular localization of interferon-inducible Myc/stat-interacting protein Nmi is regulated by a novel IFP 35 homologous domain". J. Interferon Cytokine Res. 19 (11): 1245–52. doi:10.1089/107999099312902. PMID 10574616.
Bannasch D, Weis I, Schwab M (2000). "Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN". Oncogene. 18 (48): 6810–7. doi:10.1038/sj.onc.1203090. PMID 10597290.
Zhou X, Liao J, Meyerdierks A, et al. (2000). "Interferon-alpha induces nmi-IFP35 heterodimeric complex formation that is affected by the phosphorylation of IFP35". J. Biol. Chem. 275 (28): 21364–71. doi:10.1074/jbc.M003177200. PMID 10779520.
Chen J, Shpall RL, Meyerdierks A, et al. (2000). "Interferon-inducible Myc/STAT-interacting protein Nmi associates with IFP 35 into a high molecular mass complex and inhibits proteasome-mediated degradation of IFP 35". J. Biol. Chem. 275 (46): 36278–84. doi:10.1074/jbc.M006975200. PMID 10950963.
Chen J, Naumovski L (2002). "Intracellular redistribution of interferon-inducible proteins Nmi and IFP 35 in apoptotic cells". J. Interferon Cytokine Res. 22 (2): 237–43. doi:10.1089/107999002753536211. PMID 11911807.
Li H, Lee TH, Avraham H (2002). "A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer". J. Biol. Chem. 277 (23): 20965–73. doi:10.1074/jbc.M112231200. PMID 11916966.
Sun GJ, Tong X, Dong Y, et al. (2002). "[Identification of a protein interacting with apoptin from human leucocyte cDNA library by using yeast two-hybrid screening]". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 34 (3): 369–72. PMID 12019454.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Jung HH, Lee J, Kim JH, et al. (2005). "STAT1 and Nmi are downstream targets of Ets-1 transcription factor in MCF-7 human breast cancer cell". FEBS Lett. 579 (18): 3941–6. doi:10.1016/j.febslet.2005.06.011. PMID 15996661. S2CID 23206849.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Schlierf B, Lang S, Kosian T, et al. (2005). "The high-mobility group transcription factor Sox10 interacts with the N-myc-interacting protein Nmi". J. Mol. Biol. 353 (5): 1033–42. doi:10.1016/j.jmb.2005.09.013. PMID 16214168.
Zhang L, Tang Y, Tie Y, et al. (2007). "The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling". Cell. Signal. 19 (5): 932–44. doi:10.1016/j.cellsig.2006.11.002. PMID 17197158.
Albihn A, Mo H, Yang Y, Henriksson M (2007). "Camptothecin-induced apoptosis is enhanced by Myc and involves PKCdelta signaling". Int. J. Cancer. 121 (8): 1821–9. doi:10.1002/ijc.22866. PMID 17565738. S2CID 22194144.

인간 염색체 2번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000123609 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000026946 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8668343-5] Bao J, Zervos AS (Aug 1996). "Isolation and characterization of Nmi, a novel partner of Myc proteins". Oncogene. 12 (10): 2171–6. PMID 8668343.

[pmid9989503-6] Zhu M, John S, Berg M, Leonard WJ (Mar 1999). "Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling". Cell. 96 (1): 121–30. doi:10.1016/S0092-8674(00)80965-4. PMID 9989503. S2CID 14758136.

[entrez-7] "Entrez Gene: NMI N-myc (and STAT) interactor".

[pmid11916966-8] Li H, Lee TH, Avraham H (June 2002). "A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer". J. Biol. Chem. 277 (23): 20965–73. doi:10.1074/jbc.M112231200. PMID 11916966.

[pmid10950963-9] Chen J, Shpall RL, Meyerdierks A, Hagemeier M, Böttger EC, Naumovski L (November 2000). "Interferon-inducible Myc/STAT-interacting protein Nmi associates with IFP 35 into a high molecular mass complex and inhibits proteasome-mediated degradation of IFP 35". J. Biol. Chem. 275 (46): 36278–84. doi:10.1074/jbc.M006975200. PMID 10950963.

[pmid16189514-10] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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N-myc 인터랙터

네임스페이스

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목차

기능.

상호 작용

레퍼런스

추가 정보