인간 내 단백질 부호화 유전자
아라키돈산염 15리포시게나제 타입 II 는 인간에서 ALOX15B 유전자 에 의해 인코딩되는 효소 다.[5] [6] ALOX15B는 15-리포시제네제2 (15-LO-2 또는 15-LOX-2 )로도 알려져 있으며, 관련 산소효소인 ALOX15 또는 15-리포시제네제1과 구별된다.
함수 이 유전자. 15-LOX-2 인간 15-LOX-1과 12-lipoxygenase고 인간의 5-지방산화 효소에 44%아미노산 배열이 정체성 38-39%아미노산 배열이 정체성이 구조적으로 관련 비헴성 철 dioxygenases 지방산 hydroperoxides의 생산에 관여한lipoxygenase 가족의 일원 부호화합니다.[5]15-LOX-2 개종한 아라키돈산 almo. st exclusively to the S stereoisomer of 15-Hydroperoxyicosatetraenoic acid which is commonly reduced to the S stereoisomer 15-Hydroxyeicosatetraenoic acid by ubiquitous cellular peroxidases ; it metabolizes linoleic acid less effectively, converting this fatty acid to the S stereoisomer of 13-hydroperoxyoctadecadienoic acid which is likewise rapidly 13-Hydroxyoctadecadienoic acidoic [5] ALOX15B 유전자는 17번 염색체의 짧은 팔에서 약 100킬로바이트에 이르는 관련 유전자와 유사 유전자의 군집 안에 위치한다. 대안으로 다른 ISO 양식을 인코딩하는 분할된 대본 변형이 설명되어 있다.[6]
참고 항목 참조
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