YTH 도메인 함유 단백질 1은 YTHDC1 [5] [6] [7] 유전자 에 의해 인체 내에서 암호화되는 단백질 이다.YTHDC1은 스플라이스 현장 선택에 관여하는 핵단백질이다. YT체; 세포 주기의 S상 시작에 처음 나타나 유사분열 [8]
상호 작용 YTHDC1은 다음과 상호작용하는 것 으로 나타났습니다.
질병에서의 역할 대체 스플라이싱은 많은 질병에서 변경되며 특히 암과 관련이 있다.
암 YTHDC1은 저산소 관련 혈관내피성장인자(VEGF), DNA 손상 관련 유방암 1(BRCA1) 및 호르몬 성장 드라이버인 프로게스테론 수용체(PGR) [12] [13]
전립선암에서 YTHDC1은 CD44 와 [11] [14] 메타데린과 상호작용하는 것으로 나타났다.
「 」를 참조해 주세요. N-메틸아데노신6
레퍼런스 ^ a b c ENSG000083896 GRCh38: 앙상블 릴리즈 89: ENSG00000272, ENSG000083896 : Ensembl , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000035851 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Stoilov P, Rafalska I, Stamm S (Oct 2002). "YTH: a new domain in nuclear proteins". Trends Biochem Sci . 27 (10): 495–7. doi :10.1016/S0968-0004(02)02189-8 . PMID 12368078 . ^ a b Hartmann AM, Nayler O, Schwaiger FW, Obermeier A, Stamm S (Dec 1999). "The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn)" . Mol Biol Cell . 10 (11): 3909–26. doi :10.1091/mbc.10.11.3909 . PMC 25688 PMID 10564280 . ^ "Entrez Gene: YTHDC1 YTH domain containing 1" .^ Nayler, O.; Hartmann, A. M.; Stamm, S. (2000-09-04). "The ER repeat protein YT521-B localizes to a novel subnuclear compartment" . The Journal of Cell Biology . 150 (5): 949–962. doi :10.1083/jcb.150.5.949 . ISSN 0021-9525 . PMC 2175241 PMID 10973987 . ^ a b Rafalska I, Zhang Z, Benderska N, Wolff H, Hartmann AM, Brack-Werner R, Stamm S (Aug 2004). "The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation" . Hum. Mol. Genet . 13 (15): 1535–49. doi :10.1093/hmg/ddh167 PMID 15175272 . ^ Wilkinson FL, Holaska JM, Zhang Z, Sharma A, Manilal S, Holt I, Stamm S, Wilson KL, Morris GE (Jun 2003). "Emerin interacts in vitro with the splicing-associated factor, YT521-B" . Eur. J. Biochem . 270 (11): 2459–66. doi :10.1046/j.1432-1033.2003.03617.x PMID 12755701 . ^ a b Luxton, Hayley J.; Simpson, Benjamin S.; Mills, Ian G.; Brindle, Nicola R.; Ahmed, Zeba; Stavrinides, Vasilis; Heavey, Susan; Stamm, Stefan; Whitaker, Hayley C. (2019-08-23). "The Oncogene Metadherin Interacts with the Known Splicing Proteins YTHDC1, Sam68 and T-STAR and Plays a Novel Role in Alternative mRNA Splicing" . Cancers . 11 (9): 1233. doi :10.3390/cancers11091233 ISSN 2072-6694 . PMC 6770463 PMID 31450747 . ^ Hirschfeld, Marc; Zhang, Bo; Jaeger, Markus; Stamm, Stefan; Erbes, Thalia; Mayer, Sebastian; Tong, Xiaowen; Stickeler, Elmar (November 2014). "Hypoxia-dependent mRNA expression pattern of splicing factor YT521 and its impact on oncological important target gene expression". Molecular Carcinogenesis . 53 (11): 883–892. doi :10.1002/mc.22045 . ISSN 1098-2744 . PMID 23765422 . S2CID 35669580 . ^ Zhang, Bo; Shao, Xiaowen; Zhou, Jianhong; Qiu, Jin; Wu, Yi; Cheng, Jiajing (2015-08-21). "YT521 promotes metastases of endometrial cancer by differential splicing of vascular endothelial growth factor A". Tumor Biology . 37 (12): 15543–15549. doi :10.1007/s13277-015-3908-y . ISSN 1423-0380 . PMID 26289848 . S2CID 11257001 . ^ Yoo, Byoung Kwon; Emdad, Luni; Su, Zao-zhong; Villanueva, Augusto; Chiang, Derek Y.; Mukhopadhyay, Nitai D.; Mills, Alan Scott; Waxman, Samuel; Fisher, Robert A.; Llovet, Josep M.; Fisher, Paul B. (March 2009). "Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression" . The Journal of Clinical Investigation . 119 (3): 465–477. doi :10.1172/JCI36460 . ISSN 1558-8238 . PMC 2648696 PMID 19221438 .
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