T세포림프종침입 및 전이유도단백질1

TIAM1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2D8I, 3KZD, 3KZE, 4GVC, 4GVD, 4K2O, 4K2P, 4NXP, 4NXQ, 4NXR
식별자
에일리어스	TIAM1, T세포 림프종 침입 및 전이유도단백질1, T세포 림프종 침입 및 전이1
외부 ID	OMIM : 600687 MGI : 103306 HomoloGene : 2443 GenCard : TIAM 1
유전자 위치(마우스)
크르.	16번 염색체(쥐)
끝.	89,940,657 bp
RNA발현패턴
	없음
	; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	미소관 결합; 키나아제결합; GO:0001948 단백질 결합; 지질 결합; 구아닐-플루오르화물교환인자활성; 수용체티로신인산화효소결합;
셀룰러 컴포넌트	세포질; 세포; 막; 세포-세포 접합; 세포 접촉대; 혈장막 세포질 측 외인성 성분; 혈장막; 수상척추; 축삭 성장 원뿔; 시냅스; 주축삭; 러플막; 세포 접합; 신경세포체; 체내 확장 구획; 미소관; 핵; GO:0097483, GO:0097481 시냅스 후 밀도; 글루탐산성 시냅스; 시냅스 후 밀도막 외인성 성분;
생물학적 과정	막에 대한 단백질 국재화; 아포토시스 과정; 포도당 자극에 대한 세포 반응에 관여하는 인슐린 분비 조절; GO:0007243 세포내 신호 전달; GTPase 액티비티의 GO:0032861, GO:0032862, GO:0032856 활성화; JUN인산화효소활성양성조절; 에프린수용체신호경로; 심근 비대; 비표준 Wnt 신호 경로 조절; 축삭 형성의 양성 조절; 뉴런투영확장; Wnt 시그널링 경로, 평면 셀 극성 경로; 도파민성 뉴런 분화 조절; ERK1 및 ERK2 캐스케이드 조절; 뉴런 투영 발달의 양성 조절; 아포토시스 과정의 양성 조절; 슈반세포 화학반응의 양성조절제; 단백질 결합의 양성 조절; 세포간 접착; Rac 단백질 신호 전달; Rho단백질신호전달조절; 소량 GTPase 매개 신호 전달 조절; 세포이동; 수상척추형태형성의 양성조절; 신호 변환; 코카인에 대한 반응; 세포군 증식의 양성 조절; 세포 이동의 양성 조절; NMDA선택성글루탐산수용체신호경로; 세포골격 시냅스 후 작용의 수식 조절; 간엽 전이 상피 조절; 간엽 전이 상피 양성 조절; G단백질결합수용체신호경로;
	출처:아미고 / QuickGO
맞춤법
	7074
	21844
	ENSG00000156299
	ENSMUSG00000002489
	문제 13009
	Q60610
	NM_003253
	NM_001145886; NM_001145887; NM_009384
NP_003244; NP_001340613; NP_001340614; NP_001340615; NP_001340616;
	NP_001340617; NP_001340618; NP_001340619; NP_001340620; NP_001340621; NP_001340622; NP_001340623
	없음
	위키데이터
인간 보기/편집	마우스 표시/편집

T세포 림프종 침입 및 전이유도단백질 1은 TIAM1 ^[4]^[5]^[6]유전자에 의해 인체 내에서 부호화되는 단백질이다.

구조.

TIAM1은 서브유닛으로서 BAIAP2와 밀접하게 관련되어 있습니다.여기에는 DH(DBL-homology) 도메인 1개, PDZ 도메인 1개, PH 도메인 2개 및 Ras 바인딩 RBD 도메인 1개가 포함됩니다.

기능.

TIAM1은 Rho GTP 결합 단백질의 활성을 조절하고 세포외 신호를 세포골격 활동에 연결합니다.또한 TIAM1은 Rac1, CDC42 및 RhoA를 보다 적은 범위로 활성화한다.

임상적 의의

TIAM1은 B림프종과 T림프종, 신경아세포종, 흑색종 및 암을 포함하여 검사된 거의 모든 종양 세포주에서 발견된다.

상호 작용

T세포 림프종 침입 및 전이 유도 단백질 1은 ANK1,^[7] Myc,^[8] RAC1^[9]^[10], PPP1R9B와 ^[11]상호작용하는 것으로 나타났다.

Tiam1은 또한 Tiam1을 접합부에 모집하여 상피 ^[12]접합부에서 Rac1을 활성화하는 역할을 하는 파라-싱글린과도 상호작용합니다.

레퍼런스

^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000002489 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TIAM1 T-cell lymphoma invasion and metastasis 1".
^ Chen H, Antonarakis SE (Nov 1995). "Localization of a human homolog of the mouse Tiam-1 gene to chromosome 21q22.1". Genomics. 30 (1): 123–127. doi:10.1006/geno.1995.0025. PMID 8595894.
^ Uhlenbrock K, Eberth A, Herbrand U, Daryab N, Stege P, Meier F, Friedl P, Collard JG, Ahmadian MR (Sep 2004). "The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism". Journal of Cell Science. 117 (Pt 20): 4863–4871. doi:10.1242/jcs.01367. PMID 15340013.
^ Bourguignon LY, Zhu H, Shao L, Chen YW (Jul 2000). "Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration". The Journal of Cell Biology. 150 (1): 177–191. doi:10.1083/jcb.150.1.177. PMC 2185563. PMID 10893266.
^ Otsuki Y, Tanaka M, Kamo T, Kitanaka C, Kuchino Y, Sugimura H (Feb 2003). "Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts". The Journal of Biological Chemistry. 278 (7): 5132–5140. doi:10.1074/jbc.M206733200. PMID 12446731.
^ Worthylake DK, Rossman KL, Sondek J (Dec 2000). "Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1". Nature. 408 (6813): 682–688. Bibcode:2000Natur.408..682W. doi:10.1038/35047014. PMID 11130063. S2CID 4429919.
^ Gao Y, Xing J, Streuli M, Leto TL, Zheng Y (Dec 2001). "Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors". The Journal of Biological Chemistry. 276 (50): 47530–47541. doi:10.1074/jbc.M108865200. PMID 11595749.
^ Buchsbaum RJ, Connolly BA, Feig LA (May 2003). "Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin". The Journal of Biological Chemistry. 278 (21): 18833–18841. doi:10.1074/jbc.M207876200. PMID 12531897.
^ Guillemot L, Paschoud S, Jond L, Foglia A, Citi S (Oct 2008). "Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions". Molecular Biology of the Cell. 19 (10): 4442–4453. doi:10.1091/mbc.E08-06-0558. PMC 2555940. PMID 18653465.

추가 정보

Habets GG, van der Kammen RA, Stam JC, Michiels F, Collard JG (Apr 1995). "Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin". Oncogene. 10 (7): 1371–1376. PMID 7731688.
Habets GG, van der Kammen RA, Jenkins NA, Gilbert DJ, Copeland NG, Hagemeijer A, Collard JG (1995). "The invasion-inducing TIAM1 gene maps to human chromosome band 21q22 and mouse chromosome 16". Cytogenetics and Cell Genetics. 70 (1–2): 48–51. doi:10.1159/000133989. PMID 7736788.
Michiels F, Habets GG, Stam JC, van der Kammen RA, Collard JG (May 1995). "A role for Rac in Tiam1-induced membrane ruffling and invasion". Nature. 375 (6529): 338–340. Bibcode:1995Natur.375..338M. doi:10.1038/375338a0. PMID 7753201. S2CID 4251212.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID 8619474.
Michiels F, Stam JC, Hordijk PL, van der Kammen RA, Ruuls-Van Stalle L, Feltkamp CA, Collard JG (Apr 1997). "Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation". The Journal of Cell Biology. 137 (2): 387–398. doi:10.1083/jcb.137.2.387. PMC 2139766. PMID 9128250.
Fleming IN, Elliott CM, Buchanan FG, Downes CP, Exton JH (Apr 1999). "Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation". The Journal of Biological Chemistry. 274 (18): 12753–12758. doi:10.1074/jbc.274.18.12753. PMID 10212259.
Bourguignon LY, Zhu H, Shao L, Chen YW (Jan 2000). "CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration". The Journal of Biological Chemistry. 275 (3): 1829–1838. doi:10.1074/jbc.275.3.1829. PMID 10636882.
Crompton AM, Foley LH, Wood A, Roscoe W, Stokoe D, McCormick F, Symons M, Bollag G (Aug 2000). "Regulation of Tiam1 nucleotide exchange activity by pleckstrin domain binding ligands". The Journal of Biological Chemistry. 275 (33): 25751–25759. doi:10.1074/jbc.M002050200. PMID 10835422.
Bourguignon LY, Zhu H, Shao L, Chen YW (Jul 2000). "Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration". The Journal of Cell Biology. 150 (1): 177–191. doi:10.1083/jcb.150.1.177. PMC 2185563. PMID 10893266.
Worthylake DK, Rossman KL, Sondek J (Dec 2000). "Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1". Nature. 408 (6813): 682–688. Bibcode:2000Natur.408..682W. doi:10.1038/35047014. PMID 11130063. S2CID 4429919.
Otsuki Y, Tanaka M, Yoshii S, Kawazoe N, Nakaya K, Sugimura H (Apr 2001). "Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1". Proceedings of the National Academy of Sciences of the United States of America. 98 (8): 4385–4390. Bibcode:2001PNAS...98.4385O. doi:10.1073/pnas.071411598. PMC 31844. PMID 11274357.
Gao Y, Xing J, Streuli M, Leto TL, Zheng Y (Dec 2001). "Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors". The Journal of Biological Chemistry. 276 (50): 47530–47541. doi:10.1074/jbc.M108865200. PMID 11595749.
Buchsbaum RJ, Connolly BA, Feig LA (Jun 2002). "Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade". Molecular and Cellular Biology. 22 (12): 4073–4085. doi:10.1128/MCB.22.12.4073-4085.2002. PMC 133864. PMID 12024021.
Lambert JM, Lambert QT, Reuther GW, Malliri A, Siderovski DP, Sondek J, Collard JG, Der CJ (Aug 2002). "Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism". Nature Cell Biology. 4 (8): 621–625. doi:10.1038/ncb833. PMID 12134164. S2CID 21639425.
Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K, Der CJ (Dec 2002). "RhoG signals in parallel with Rac1 and Cdc42". The Journal of Biological Chemistry. 277 (49): 47810–47817. doi:10.1074/jbc.M203816200. PMID 12376551.
Otsuki Y, Tanaka M, Kamo T, Kitanaka C, Kuchino Y, Sugimura H (Feb 2003). "Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts". The Journal of Biological Chemistry. 278 (7): 5132–5140. doi:10.1074/jbc.M206733200. PMID 12446731.
Buchsbaum RJ, Connolly BA, Feig LA (May 2003). "Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin". The Journal of Biological Chemistry. 278 (21): 18833–18841. doi:10.1074/jbc.M207876200. PMID 12531897.

[refGRCm38Ensembl-1] GRCm38: 앙상블 릴리즈 89: ENSMUSG00000002489 - 앙상블, 2017년 5월

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Entrez Gene: TIAM1 T-cell lymphoma invasion and metastasis 1".

[pmid8595894-5] Chen H, Antonarakis SE (Nov 1995). "Localization of a human homolog of the mouse Tiam-1 gene to chromosome 21q22.1". Genomics. 30 (1): 123–127. doi:10.1006/geno.1995.0025. PMID 8595894.

[pmid15340013-6] Uhlenbrock K, Eberth A, Herbrand U, Daryab N, Stege P, Meier F, Friedl P, Collard JG, Ahmadian MR (Sep 2004). "The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism". Journal of Cell Science. 117 (Pt 20): 4863–4871. doi:10.1242/jcs.01367. PMID 15340013.

[pmid10893266-7] Bourguignon LY, Zhu H, Shao L, Chen YW (Jul 2000). "Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration". The Journal of Cell Biology. 150 (1): 177–191. doi:10.1083/jcb.150.1.177. PMC 2185563. PMID 10893266.

[pmid12446731-8] Otsuki Y, Tanaka M, Kamo T, Kitanaka C, Kuchino Y, Sugimura H (Feb 2003). "Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts". The Journal of Biological Chemistry. 278 (7): 5132–5140. doi:10.1074/jbc.M206733200. PMID 12446731.

[pmid11130063-9] Worthylake DK, Rossman KL, Sondek J (Dec 2000). "Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1". Nature. 408 (6813): 682–688. Bibcode:2000Natur.408..682W. doi:10.1038/35047014. PMID 11130063. S2CID 4429919.

[pmid11595749-10] Gao Y, Xing J, Streuli M, Leto TL, Zheng Y (Dec 2001). "Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors". The Journal of Biological Chemistry. 276 (50): 47530–47541. doi:10.1074/jbc.M108865200. PMID 11595749.

[pmid12531897-11] Buchsbaum RJ, Connolly BA, Feig LA (May 2003). "Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin". The Journal of Biological Chemistry. 278 (21): 18833–18841. doi:10.1074/jbc.M207876200. PMID 12531897.

[pmid18653465-12] Guillemot L, Paschoud S, Jond L, Foglia A, Citi S (Oct 2008). "Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions". Molecular Biology of the Cell. 19 (10): 4442–4453. doi:10.1091/mbc.E08-06-0558. PMC 2555940. PMID 18653465.

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T세포림프종침입 및 전이유도단백질1

네임스페이스

더

목차

구조.

기능.

임상적 의의

상호 작용

레퍼런스

추가 정보